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Pterocarpans and is...
Pterocarpans and isoflavones from the roots of Millettia micans and of Millettia dura
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Makungu, Marco (author)
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- Deyou, Tsegaye (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Gruhonjic, Amra (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Sahlgrenska Cancer Center,Department of Chemistry and Molecular Biology
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Holleran, John P. (author)
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Duffy, Sandra (author)
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Heydenreich, Matthias (author)
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- Fitzpatrick, Paul A. (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Landberg, Göran, 1963 (author)
- Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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Koch, Andreas (author)
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Derese, Solomon (author)
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Pelletier, Jerry (author)
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Avery, Vicky M. (author)
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- Erdelyi, Mate, 1975 (author)
- Gothenburg University,Göteborgs universitet,Svenskt NMR-centrum vid Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Swedish NMR Centre at Göteborg University,Department of Chemistry and Molecular Biology
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Yenesew, Abiy (author)
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(creator_code:org_t)
- 2016
- 2016
- English.
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In: Advances in Drug Discovery and Development. ; 1:1, s. 1-8
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
Close
- From the CH2Cl2/CH3OH (1:1) extract of the root bark of Millettia micans, a new pterocarpan, (6aR,11aR)-7,8,9-trimethoxy-3-hydroxypterocarpan (1), named micanspterocarpan, was isolated. Similarinvestigation of the CH2Cl2/CH3OH (1:1) extract of the root bark of Millettia dura gave a further new pterocarpan,3-O-prenylmaackiain (2) along with six known isoflavones (3-8) and a chalcone (9). All purifiedcompounds were identified by NMR and MS, and the absolute configuration of 1 was established by quantumchemical CD calculation. The isolated constituents, calopogonium isoflavone B (3) and isoerythrin A-4'-(3-methylbut-2-enyl) ether (4) showed marginal activities against the 3D7 and the Dd2 strains of Plasmodiumfalciparum (70-90% inhibition at 40 M). Maximaisoflavone B (5) and 7,2'-dimethoxy-4',5'-methylenedioxyisoflavone (7) were weakly cytotoxic (IC50 153.5 and 174.1 uM, respectively) against theMDB-MB-231 human breast cancer cell line. None of the tested compounds showed toxicity against theHEK-293 human embryonic kidney cell line at 40 uM.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Keyword
- Millettia micans
- pterocarpan
- malaria
Publication and Content Type
- ref (subject category)
- art (subject category)
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Makungu, Marco
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Deyou, Tsegaye
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Gruhonjic, Amra
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Holleran, John P ...
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Duffy, Sandra
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Heydenreich, Mat ...
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Fitzpatrick, Pau ...
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Landberg, Göran, ...
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Koch, Andreas
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Derese, Solomon
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Pelletier, Jerry
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Avery, Vicky M.
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Erdelyi, Mate, 1 ...
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Yenesew, Abiy
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medicinal Chemis ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Other Basic Medi ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Organic Chemistr ...
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University of Gothenburg