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Cranial irradiation...
Cranial irradiation induces transient microglia accumulation, followed by long-lasting inflammation and loss of microglia
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- Han, W. (author)
- Karolinska Institutet
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Umekawa, T. (author)
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- Zhou, K. (author)
- Karolinska Institutet
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- Zhang, X. M. (author)
- Karolinska Institutet
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- Ohshima, M. (author)
- Karolinska Institutet
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- Dominguez, C. A. (author)
- Karolinska Institutet
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- Harris, R. A. (author)
- Karolinska Institutet
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- Zhu, Changlian, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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- Blomgren, K. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2016-10-26
- 2016
- English.
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In: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 7:50, s. 82305-82323
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Abstract
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- The relative contribution of resident microglia and peripheral monocyte-derived macrophages in neuroinflammation after cranial irradiation is not known. A single dose of 8 Gy was administered to postnatal day 10 (juvenile) or 90 (adult) CX3CR1(GFP/+) CCR2(RFP/+) mouse brains. Microglia accumulated in the subgranular zone of the hippocampal granule cell layer, where progenitor cell death was prominent. The peak was earlier (6 h vs. 24 h) but less pronounced in adult brains. The increase in juvenile, but not adult, brains was partly attributed to proliferation. Microglia numbers then decreased over time to 39% (juvenile) and 58% (adult) of controls 30 days after irradiation, largely as a result of cell death. CD68 was expressed in 90% of amoeboid microglia in juvenile hippocampi but only in 9% of adult ones. Isolated hippocampal microglia revealed reduced CD206 and increased IL1-beta expression after irradiation, more pronounced in juvenile brains. CCL2 and IL-1 beta increased after irradiation, more in juvenile hippocampi, and remained elevated at all time points. In summary, microglia activation after irradiation was more pronounced, protracted and pro-inflammatory by nature in juvenile than in adult hippocampi. Common to both ages was long-lasting inflammation and the absence of monocyte-derived macrophages.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- irradiation
- neurogenesis
- neuroinflammation
- microglia
- monocyte
- macrophage
- monocyte chemoattractant protein-1
- young-mouse brain
- adult hippocampal
- neurogenesis
- fractalkine receptor cx(3)cr1
- progenitor-cell
- cognitive
- function
- rat-brain
- radiation
- activation
- neuroinflammation
- Oncology
- Cell Biology
- wler jf
- 1989
- british journal of radiology
- v62
- p679
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Han, W.
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Umekawa, T.
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Zhou, K.
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Zhang, X. M.
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Ohshima, M.
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Dominguez, C. A.
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show more...
-
Harris, R. A.
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Zhu, Changlian, ...
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Blomgren, K.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Oncotarget
- By the university
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University of Gothenburg
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Karolinska Institutet