Characterization of vigabatrin-associated optic atrophy.

• To report the discovery of a previously unknown form of optic atrophy associated with use of the anti-epileptic drug vigabatrin.We conducted a retrospective analysis of digitally enhanced ocular fundus photographs, kinetic visual field maps and treatment parameters for 25 patients, who were selected to represent a large spectrum of visual field defects.In all, 21 patients (84%) evidenced subtle, diffuse atrophy of the retinal nerve fibre layer, in a pattern accessible to scoring. Atrophy scores correlated with visual field remains and cumulative vigabatrin doses. A pathophysiological model is proposed that involves the lengths of intraocular (unmyelinated) retinal ganglion cell axons.Optic atrophy attests to the irreversible nature of vigabatrin's visual toxicity. Ocular fundus imaging should prove useful for objectively monitoring vigabatrin-treated subjects for visual toxicity.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oftalmologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Ophthalmology (hsv//eng)

Nyckelord

Anticonvulsants

administration & dosage

adverse effects

Dose-Response Relationship

Drug

Fundus Oculi

Humans

Image Processing

Computer-Assisted

Nerve Fibers

pathology

Optic Atrophy

chemically induced

pathology

physiopathology

Retinal Ganglion Cells

pathology

Retinal Vessels

pathology

Retrospective Studies

Vigabatrin

administration & dosage

adverse effects

Visual Fields

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)