WFRF:(Lindberger M)
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- Lindberger, M (author)
Gabapentin versus vigabatrin as first add-on for patients with partial seizures that failed to respond to monotherapy: a randomized, double-blind, dose titration study. GREAT Study Investigators Group. Gabapentin in Refractory Epilepsy Add-on Treatment.
- Article/chapterEnglish2000
Publisher, publication year, extent ...
- Wiley,2000
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/250983
- https://gup.ub.gu.se/publication/250983URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1948290URI
- https://doi.org/10.1111/j.1528-1157.2000.tb04607.xDOI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
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Notes
- Our objective was to compare the efficacy and safety of gabapentin and vigabatrin as first-line add-on treatment in patients with partial epilepsy.This was a multicenter, double-blind, randomized dose titration study. After baseline assessment and randomization, the dose could be increased if seizures persisted and reduced if side effects occurred. Health-related quality of life was assessed at baseline and at the end of the study. By a protocol amendment post hoc, all randomized patients were offered a standardized perimetry examination at the end of the study. Improvement rate was the proportion of patients with a reduction of seizure frequency of at least 50% during an 8-week period without any adverse events causing withdrawal.One hundred two patients were randomized and analyzed on an intent-to-treat basis. The improvement rate was 48% in the gabapentin group and 56% in the vigabatrin group. The improvement rate, when per protocol criteria were fulfilled, was 57% in the gabapentin group and 59% in the vigabatrin group. The proportion of seizure-free patients was 31% in the gabapentin group and 39% in the vigabatrin group. There was no difference in quality-of-life scores between the groups. Perimetry after termination of the study on 64 patients showed abnormal results in 3 of 32 patients in the vigabatrin group.Approximately one third of the patients in both groups became seizure-free. Although no major differences were seen in terms of the improvement rate between the groups, equivalence between the two drugs was not found.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Oftalmologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Ophthalmology hsv//eng
- Acetates
- administration & dosage
- therapeutic use
- Adolescent
- Adult
- Aged
- Amines
- Anticonvulsants
- administration & dosage
- therapeutic use
- Child
- Cyclohexanecarboxylic Acids
- Double-Blind Method
- Drug Administration Schedule
- Drug Therapy
- Combination
- Epilepsies
- Partial
- drug therapy
- Female
- Humans
- Male
- Middle Aged
- Research Design
- Retrospective Studies
- Treatment Outcome
- Vigabatrin
- administration & dosage
- therapeutic use
- gamma-Aminobutyric Acid
Added entries (persons, corporate bodies, meetings, titles ...)
- Alenius, M (author)
- Frisén, Lars,1939Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för oftalmologi,Institute of Clinical Neurosciences, Section of Ophtalmology(Swepub:gu)xfrisl (author)
- Johannessen, S I (author)
- Larsson, S (author)
- Malmgren, K (author)
- Tomson, TKarolinska Institutet (author)
- Göteborgs universitetInstitutionen för klinisk neurovetenskap, Sektionen för oftalmologi (creator_code:org_t)
Related titles
- In:Epilepsia: Wiley41:10, s. 1289-950013-95801528-1167
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