Commencing growth hormone replacement in adults with a fixed low dose. Effects on serum lipoproteins, glucose metabolism, body composition, and cardiovascular function.

The safety and effects of a fixed low dose of growth hormone (GH), 0.17 mg/day was evaluated for 3 months, on glucose metabolism, serum lipids, body composition and cardiac function in 53 GH deficient adults aged 18-78 years. Body composition was determined by dual energy X-ray absorptiometry and total body water was determined by bioelectrical impedance. Echocardiography was used to assess cardiac function and bicycle ergonometry was used to determine exercise capacity. All investigations were performed at baseline and after 3 months. At 3 months, serum levels of insulin-like growth factor (IGF)-I, IGF binding protein (IGFBP)-3 and lipoprotein (a) and lean body mass were increased (P<0.05). Total and low density lipoprotein cholesterol levels and fat mass were reduced (P<0.05). There was an increase in the serum glucose value at 120 min after an oral glucose tolerance test performed at 3 months (P<0.05), no other changes in glucose metabolism or in cardiac function were noted. Side-effects were few and mild. This fixed low-dose regime resulted in improvements in body composition and lipid profile, without causing serious side effects. This is therefore a valid method to institute GH replacement in adults.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
Adult
Blood Glucose
drug effects
metabolism
Body Composition
drug effects
Body Mass Index
Cardiovascular System
drug effects
Dose-Response Relationship
Drug
Electrocardiography
drug effects
Exercise Test
Female
Homeostasis
Hormone Replacement Therapy
Human Growth Hormone
deficiency
therapeutic use
Humans
Insulin-Like Growth Factor Binding Protein 3
blood
Insulin-Like Growth Factor I
metabolism
Lipoproteins
blood
drug effects
Male
Middle Aged
Pituitary Diseases
drug therapy
etiology
Recombinant Proteins
therapeutic use

Bramnert, M (författare)
Thorén, MKarolinska Institutet (författare)
Werner, SKarolinska Institutet (författare)
Johannsson, Gudmundur,1960Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism(Swepub:gu)xjgudn (författare)
Karolinska InstitutetInstitutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism (creator_code:org_t)

Ingår i:Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society: Elsevier BV11:5, s. 273-811096-6374

Av författaren/redakt...: Gillberg, P; Bramnert, M; Thorén, M; Werner, S; Johannsson, Gudm ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

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