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- Trainer, P J (author)
Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant.
- Article/chapterEnglish2000
Publisher, publication year, extent ...
- 2000
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/251174
- https://gup.ub.gu.se/publication/251174URI
- https://doi.org/10.1056/NEJM200004203421604DOI
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- Language:English
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- SwePubSwePub
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Notes
- Patients with acromegaly are currently treated with surgery, radiation therapy, and drugs to reduce hypersecretion of growth hormone, but the treatments may be ineffective and have adverse effects. Pegvisomant is a genetically engineered growth hormone-receptor antagonist that blocks the action of growth hormone.We conducted a 12-week, randomized, double-blind study of three daily doses of pegvisomant (10 mg, 15 mg, and 20 mg) and placebo, given subcutaneously, in 112 patients with acromegaly.The mean (+/-SD) serum concentration of insulin-like growth factor I (IGF-I) decreased from base line by 4.0+/-16.8 percent in the placebo group, 26.7+/-27.9 percent in the group that received 10 mg of pegvisomant per day, 50.1+/-26.7 percent in the group that received 15 mg of pegvisomant per day, and 62.5+/-21.3 percent in the group that received 20 mg of pegvisomant per day (P<0.001 for the comparison of each pegvisomant group with placebo), and the concentrations became normal in 10 percent, 54 percent, 81 percent, and 89 percent of patients, respectively (P<0.001 for each comparison with placebo). Among patients treated with 15 mg or 20 mg of pegvisomant per day, there were significant decreases in ring size, soft-tissue swelling, the degree of excessive perspiration, and fatigue. The score fortotal symptoms and signs of acromegaly decreased significantly in all groups receiving pegvisomant (P< or =0.05). The incidence of adverse effects was similar in all groups.On the basis of these preliminary results, treatment of patients who have acromegaly with a growth hormone-receptor antagonist results in a reduction in serum IGF-I concentrations and in clinical improvement.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
- Acromegaly
- blood
- drug therapy
- Adenoma
- drug therapy
- pathology
- Adult
- Autoantibodies
- blood
- Double-Blind Method
- Female
- Human Growth Hormone
- adverse effects
- analogs & derivatives
- blood
- immunology
- therapeutic use
- Humans
- Insulin-Like Growth Factor I
- metabolism
- Male
- Middle Aged
- Pituitary Neoplasms
- drug therapy
- pathology
- Receptors
- Somatotropin
- antagonists & inhibitors
Added entries (persons, corporate bodies, meetings, titles ...)
- Drake, W M (author)
- Katznelson, L (author)
- Freda, P U (author)
- Herman-Bonert, V (author)
- van der Lely, A J (author)
- Dimaraki, E V (author)
- Stewart, P M (author)
- Friend, K E (author)
- Vance, M L (author)
- Besser, G M (author)
- Scarlett, J A (author)
- Thorner, M O (author)
- Parkinson, C (author)
- Klibanski, A (author)
- Powell, J S (author)
- Barkan, A L (author)
- Sheppard, M C (author)
- Malsonado, M (author)
- Rose, D R (author)
- Clemmons, D R (author)
- Johannsson, Gudmundur,1960Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism(Swepub:gu)xjgudn (author)
- Bengtsson, B A (author)
- Stavrou, S (author)
- Kleinberg, D L (author)
- Cook, D M (author)
- Phillips, L S (author)
- Bidlingmaier, M (author)
- Strasburger, C J (author)
- Hackett, S (author)
- Zib, K (author)
- Bennett, W F (author)
- Davis, R J (author)
- Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism (creator_code:org_t)
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- In:The New England journal of medicine342:16, s. 1171-70028-4793
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- Dimaraki, E V
- Stewart, P M
- Friend, K E
- Vance, M L
- Besser, G M
- Scarlett, J A
- Thorner, M O
- Parkinson, C
- Klibanski, A
- Powell, J S
- Barkan, A L
- Sheppard, M C
- Malsonado, M
- Rose, D R
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- Stavrou, S
- Kleinberg, D L
- Cook, D M
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