WFRF:(Janusz M)
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- Hveem, T. S. (author)
Changes in Chromatin Structure in Curettage Specimens Identifies High-Risk Patients in Endometrial Cancer
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- 2017-01-08
- American Association for Cancer Research (AACR),2017
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/251456
- https://gup.ub.gu.se/publication/251456URI
- https://doi.org/10.1158/1055-9965.epi-16-0215DOI
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- Language:English
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- SwePubSwePub
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- Background: Most endometrial carcinoma patients are diagnosed at an early stage with a good prognosis. However, a relatively low fraction with lethal disease constitutes a substantial number of patients due to the high incidence rate. Preoperative identification of patients with high risk and low risk for poor outcome is necessary to tailor treatment. Nucleotyping refers to characterization of cell nuclei by image cytometry, including the assessment of chromatin structure by nuclear texture analysis. This method is a strong prognostic marker in many cancers but has not been evaluated in preoperative curettage specimens from endometrial carcinoma. Methods: The prognostic impact of changes in chromatin structure quantified with Nucleotyping was evaluated in preoperative curettage specimens from 791 endometrial carcinoma patients prospectively included in the MoMaTEC multicenter trial. Results: Nucleotyping was an independent prognostic marker of disease-specific survival in preoperative curettage specimens among patients with Federation Internationale des Gynaecologistes et Obstetristes (FIGO) stage I-II disease (HR = 2.9; 95% CI, 1.2-6.5; P - 0.013) and significantly associated with age, FIGO stage, histologic type, histologic grade, myometrial infiltration, lymph node status, curettage histology type, and DNA ploidy. Conclusions: Nucleotyping in preoperative curettage specimens is an independent prognostic marker for disease-specific survival, with potential to supplement existing parameters for risk stratification to tailor treatment. Impact: This is the first study to evaluate the prognostic impact of Nucleotyping in curettage specimens from endometrial carcinoma and shows that this may be a clinically useful prognostic marker in endometrial cancer. External validation is warranted. (C) 2016 AACR.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
- nuclear image-analysis
- appearing uterine glands
- texture features
- dna-ploidy
- paraffin section
- carcinoma
- differentiation
- adenocarcinoma
- hyperplasia
- validation
- Oncology
- Public
- Environmental & Occupational Health
Added entries (persons, corporate bodies, meetings, titles ...)
- Njolstad, T. S. (author)
- Nielsen, B. (author)
- Syvertsen, R. A. (author)
- Nesheim, J. A. (author)
- Kjaereng, M. L. (author)
- Kildal, W. (author)
- Pradhan, M. (author)
- Marcickiewicz, JanuszGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xmarcj (author)
- Tingulstad, S. (author)
- Staff, A. C. (author)
- Haugland, H. K. (author)
- Eraker, R. (author)
- Oddenes, K. (author)
- Rokne, J. A. (author)
- Tjugum, J. (author)
- Lode, M. S. (author)
- Amant, F. (author)
- Werner, H. M. J. (author)
- Bjorge, L. (author)
- Albregtsen, F. (author)
- Liestol, K. (author)
- Salvesen, H. B. (author)
- Trovik, J. (author)
- Danielsen, H. E. (author)
- Enitec Network MoMaTEC Study Grp, Enitec Network MoMaTEC Study Grp (author)
- Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi (creator_code:org_t)
Related titles
- In:Cancer Epidemiology Biomarkers & Prevention: American Association for Cancer Research (AACR)26:1, s. 61-671055-99651538-7755
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- Kildal, W.
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- Rokne, J. A.
- Tjugum, J.
- Lode, M. S.
- Amant, F.
- Werner, H. M. J.
- Bjorge, L.
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- Liestol, K.
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