Search: id:"swepub:oai:gup.ub.gu.se/251966" >
Blood-Brain Barrier...
Blood-Brain Barrier Disruption Is Initiated During Primary HIV Infection and Not Rapidly Altered by Antiretroviral Therapy.
- Article/chapterEnglish2017
Publisher, publication year, extent ...
-
2017-03-29
-
Oxford University Press (OUP),2017
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/251966
-
https://gup.ub.gu.se/publication/251966URI
-
https://doi.org/10.1093/infdis/jix013DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
We explored the establishment of abnormal blood-brain barrier (BBB) permeability and its relationship to neuropathogenesis during primary human immunodeficiency virus (HIV) infection by evaluating the cerebrospinal fluid (CSF) to serum albumin quotient (QAlb) in patients with primary HIV infection. We also analyzed effects of initiating combination antiretroviral therapy (cART).The QAlb was measured in longitudinal observational studies of primary HIV infection. We analyzed trajectories of the QAlb before and after cART initiation, using mixed-effects models, and associations between the QAlb and the CSF level of neurofilament light chain (NFL), the ratio of N-acetylaspartate to creatinine levels (a magnetic resonance spectroscopy neuronal integrity biomarker), and neuropsychological performance.The baseline age-adjusted QAlb was elevated in 106 patients with primary HIV infection (median time of measurement, 91 days after infection), compared with that in 64 controls (P = .02). Before cART initiation, the QAlb increased over time in 84 participants with a normal baseline QAlb (P = .006) and decreased in 22 with a high baseline QAlb (P = .011). The QAlb did not change after a median cART duration of 398 days, initiated at a median interval of 225 days after infection (P = .174). The QAlb correlated with the NFL level at baseline (r = 0.497 and P < .001) and longitudinally (r = 0.555 and P < .001) and with the ratio of N-acetylaspartate to creatinine levels in parietal gray matter (r = -0.352 and P < .001 at baseline and r = -0.387 and P = .008 longitudinally) but not with neuropsychological performance.The QAlb rises during primary HIV infection, associates with neuronal injury, and does not significantly improve over a year of treatment. BBB-associated neuropathogenesis in HIV-infected patients may initiate during primary infection.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Li, Fang-Yong
(author)
-
Hagberg, Lars,1951Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xhagbl
(author)
-
Fuchs, Dietmar
(author)
-
Robertson, Kevin
(author)
-
Meyerhoff, Dieter J
(author)
-
Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(author)
-
Gisslén, Magnus,1962Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xgissm
(author)
-
Price, Richard W
(author)
-
Spudich, Serena
(author)
-
Göteborgs universitetInstitutionen för biomedicin, avdelningen för infektionssjukdomar
(creator_code:org_t)
Related titles
-
In:The Journal of infectious diseases: Oxford University Press (OUP)215:7, s. 1132-11401537-66130022-1899
Internet link
Find in a library
To the university's database
- By the author/editor
-
Rahimy, Elham
-
Li, Fang-Yong
-
Hagberg, Lars, 1 ...
-
Fuchs, Dietmar
-
Robertson, Kevin
-
Meyerhoff, Diete ...
-
show more...
-
Zetterberg, Henr ...
-
Gisslén, Magnus, ...
-
Price, Richard W
-
Spudich, Serena
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
The Journal of i ...
- By the university
-
University of Gothenburg