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Analysis of immune-...
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Beecham, Ashley HKarolinska Institutet,University of Miami, FL USA,Childrens Hospital Philadelphia, PA USA
(author)
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2013-09-29
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Springer Science and Business Media LLC,2013
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/252115
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https://gup.ub.gu.se/publication/252115URI
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https://doi.org/10.1038/ng.2770DOI
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https://lup.lub.lu.se/record/4205109URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:127684109URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-102079URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|US National Institutes of Health||Wellcome Trust||UK MS Society||UK Medical Research Council||US National MS Society||Cambridge National Institute for Health Research (NIHR) Biomedical Research Centre||DeNDRon||Swedish Brain Foundation||Swedish Research Council||Knut and Alice Wallenberg Foundation||Swedish Heart-Lung Foundation||Foundation for Strategic Research||
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Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls. In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 5.0 × 10(-8)), 3 of which we found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex. With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.
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Patsopoulos, Nikolaos ABrigham and Womens Hospital, MA USA
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Xifara, Dionysia KUniversity of Oxford, England,Seinajoki Central Hospital, Finland
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Davis, Mary FVanderbilt University, TN USA
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Kemppinen, AnuUniversity of Cambridge, England
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Cotsapas, ChrisBroad Institute Harvard and MIT, MA USA,University of Medical Centre Hamburg Eppendorf, Germany,University of Calif San Francisco, CA USA,Vanderbilt University, TN USA,Technical University of Munich, Germany
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Shah, Tejas SWellcome Trust Sanger Institute, England,Royal Preston Hospital, England,Norfolk and Norwich Hospital, England
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Spencer, ChrisUniversity of Oxford, England
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Goris, AnKatholieke University of Leuven, Belgium
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D'Alfonso, SandraUniversity of Piemonte Orientale, Italy
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Anderson, CarlWellcome Trust Sanger Institute, England
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Andrews, RobertWellcome Trust Sanger Institute, England
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Søndergaard, Helle BachCopenhagen University Hospital, Denmark
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Baker, AmieUniversity of Cambridge, England
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Band, GavinUniversity of Oxford, England
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Baranzini, Sergio EUniversity of Calif San Francisco, CA USA
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Barizzone, NadiaUniversity of Piemonte Orientale, Italy
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Barrett, JeffreyWellcome Trust Sanger Institute, England
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Bellenguez, CélineUniversity of Oxford, England
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Bergamaschi, LauraUniversity of Piemonte Orientale, Italy
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Bernardinelli, LuisaMRC, England
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Berthele, AchimTechnical University of Munich, Germany
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Binder, Thomas M CKarolinska Institutet,Karolinska Institute, Sweden,Broad Institute Harvard and MIT, MA USA
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Blackburn, HannahWellcome Trust Sanger Institute, England
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Bomfim, Izaura LKarolinska Institutet,Karolinska Institute, Sweden
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Brambilla, PaolaIst Science San Raffaele, Italy
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Broadley, SimonGriffith University, Australia
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Brochet, BrunoUniversity of Bordeaux 2, France
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Brundin, LouKarolinska Institutet,Karolinska Institute, Sweden
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Buck, DorotheaTechnical University of Munich, Germany
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Butzkueven, HelmutUniversity of Melbourne, Australia
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Caillier, Stacy JUniversity of Calif San Francisco, CA USA
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Comi, GiancarloIst Science San Raffaele, Italy
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Cosemans, LeentjeKatholieke University of Leuven, Belgium
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Cournu-Rebeix, IsabelleUniversity of Paris 06, France
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Cree, Bruce A CUniversity of Cambridge, England
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Cusi, DanieleUniversity of Milan, Italy
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Damotte, VincentUniversity of Paris 06, France
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Defer, GillesCHU Caen, France
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Delgado, Silvia RUniversity of Miami, FL USA
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Deloukas, PanosWellcome Trust Sanger Institute, England
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di Sapio, AlessiaUniversity of San Luigi, Italy
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Dilthey, Alexander TUniversity of Oxford, England
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Donnelly, PeterUniversity of Oxford, England
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Dubois, BénédicteKatholieke University of Leuven, Belgium
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Duddy, MartinRoyal Victoria Infirm, England
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Edkins, SarahWellcome Trust Sanger Institute, England
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Elovaara, IrinaUniversity of Tampere, Finland
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Esposito, FedericaIst Science San Raffaele, Italy
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Evangelou, NikosUniversity of Nottingham Hospital, England
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Fiddes, BarnabyUniversity of Cambridge, England
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Field, JudithUniversity of Melbourne, Australia
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Franke, AndreUniversity of Kiel, Germany
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Freeman, ColinUniversity of Oxford, England
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Frohlich, Irene YBrigham and Womens Hospital, MA USA
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Galimberti, DanielaUniversity of Milan, Italy
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Gieger, ChristianGerman Research Centre Environm Heatlh, Germany
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Gourraud, Pierre-AntoineUniversity of Calif San Francisco, CA USA
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Graetz, ChristianeJohannes Gutenberg University of Mainz, Germany
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Graham, AndrewIpswich Hospital National Health Serv NHS Trust, England
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Grummel, VerenaTechnical University of Munich, Germany
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Guaschino, ClaraIst Science San Raffaele, Italy
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Hadjixenofontos, AthenaUniversity of Miami, FL USA
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Hakonarson, HakonKarolinska Institutet,Brigham and Womens Hospital, MA USA
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Halfpenny, ChristopherSouthampton Gen Hospital, England
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Hall, PerKarolinska Institutet,Karolinska Institute, Sweden
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Harley, JamesHull Royal Infirm, England
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Hawkins, CliveKeele University, England
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Hellenthal, GarrettUCL, England
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Hillier, CharlesPoole Gen Hospital, England
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Hobart, JeremyUniversity of Plymouth, England
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Hoshi, MuniTechnical University of Munich, Germany
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Hunt, Sarah E
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Jelčić, IlijasUniversity of Medical Centre Hamburg Eppendorf, Germany
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Jochim, AngelaTechnical University of Munich, Germany
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Kendall, BrianLeicester Royal Infirm, England
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Kilpatrick, TrevorUniversity of Melbourne, Australia
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Koivisto, Keijo
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Konidari, IoannaUniversity of Miami, FL USA
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Korn, ThomasTechnical University of Munich, Germany
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Kronsbein, HelenaTechnical University of Munich, Germany
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Langford, CordeliaWellcome Trust Sanger Institute, England
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Larsson, MalinLinköpings universitet,Bioinformatik,Tekniska högskolan(Swepub:liu)malla74
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Lathrop, MarkCentre Etud Polymorphisme Humain, France
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Lebrun-Frenay, ChristineCHRU Nice, France
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Lechner-Scott, JeannetteUniversity of Newcastle, Australia
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Lee, Michelle H
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Leone, Maurizio AOsped Maggiore Novara, Italy
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Leppä, VirpiUniversity of Helsinki, Finland
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Liberatore, GiuseppeIst Science San Raffaele, Italy
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Lie, Benedicte AUniversity of Oslo, Norway
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Lill, Christina MJohannes Gutenberg University of Mainz, Germany
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Lindén, Magdalena
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Link, JennyKarolinska Institutet,Karolinska Institute, Sweden
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Luessi, FelixJohannes Gutenberg University of Mainz, Germany
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Lycke, Jan,1956Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,University of Gothenburg, Sweden(Swepub:gu)xlycja
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Macciardi, FabioUniversity of Calif Irvine, CA USA
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Männistö, SatuNational Institute Health and Welf, Finland
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Manrique, Clara PUniversity of Miami, FL USA
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Martin, RolandUniversity of Medical Centre Hamburg Eppendorf, Germany
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Martinelli, VittorioIst Science San Raffaele, Italy
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Mason, DeborahCanterbury Dist Health Board, New Zealand
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Mazibrada, GordonQueen Elizabeth Medical Centre, England
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McCabe, Cristin
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Mero, Inger-LiseOslo University Hospital, Norway
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Mescheriakova, JuliaErasmus University, Netherlands
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Moutsianas, LoukasUniversity of Oxford, England
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Myhr, Kjell-MortenHaukeland Hospital, Norway
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Nagels, GuyNational Multiple Sclerosis Centre Melsbroek, Belgium
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Nicholas, RichardCharing Cross Hospital, England
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Nilsson, PetraLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden(Swepub:lu)neur-pn8
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Piehl, FredrikKarolinska Institutet,Karolinska Institute, Sweden
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Pirinen, MattiUniversity of Oxford, England
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Price, Siân ERoyal Hallamshire Hospital, England
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Quach, HongUniversity of Calif Berkeley, CA USA
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Reunanen, MauriUniversity of Oulu, Finland
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Robberecht, WimVesalius Research Centre, Belgium
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Robertson, Neil PCardiff University, Wales
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Rodegher, MariaemmaIst Science San Raffaele, Italy
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Rog, DavidSalford Royal NHS Fdn Trust, England
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Salvetti, MarcoUniversity of Roma La Sapienza, Italy
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Schnetz-Boutaud, Nathalie C
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Sellebjerg, FinnCopenhagen University Hospital, Denmark
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Selter, Rebecca C
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Schaefer, CatherineKaiser Permanente Div Research, CA USA
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Shaunak, SandipUniversity of Melbourne, Australia
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Shen, LingKaiser Permanente Div Research, CA USA
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Shields, Simon
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Siffrin, VolkerJohannes Gutenberg University of Mainz, Germany
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Slee, MarkFlinders University of S Australia, Australia
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Sorensen, Per SoelbergCopenhagen University Hospital, Denmark
(author)
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Sorosina, MelissaIst Science San Raffaele, Italy
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Sospedra, MireiaUniversity of Medical Centre Hamburg Eppendorf, Germany
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Spurkland, AnneUniversity of Oslo, Norway
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Strange, AmyUniversity of Oxford, England
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Sundqvist, EmilieKarolinska Institute, Sweden
(author)
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Thijs, VincentVesalius Research Centre, Belgium
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Thorpe, JohnPeterborough City Hospital, England
(author)
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Ticca, AnnaSan Francesco Hospital, Italy
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Tienari, PenttiUniversity of Helsinki, Finland
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van Duijn, CorneliaErasmus MC, Netherlands
(author)
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Visser, Elizabeth M
(author)
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Vucic, SteveUniversity of Sydney, Australia
(author)
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Westerlind, HelgaKarolinska Institute, Sweden
(author)
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Wiley, James S
(author)
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Wilkins, AlastairUniversity of Bristol, England
(author)
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Wilson, James FUniversity of Edinburgh, Scotland
(author)
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Winkelmann, JulianeTechnical University of Munich, Germany
(author)
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Zajicek, JohnUniversity of Plymouth, England
(author)
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Zindler, EvaJohannes Gutenberg University of Mainz, Germany
(author)
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Haines, Jonathan LVanderbilt University, TN USA
(author)
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Pericak-Vance, Margaret AUniversity of Miami, FL USA
(author)
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Ivinson, Adrian JHarvard University, MA USA
(author)
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Stewart, GraemeUniversity of Sydney, Australia
(author)
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Hafler, DavidBroad Institute Harvard and MIT, MA USA
(author)
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Hauser, Stephen LUniversity of Calif San Francisco, CA USA
(author)
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Compston, Alastair
(author)
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McVean, GilUniversity of Oxford, England
(author)
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De Jager, PhilipBrigham and Womens Hospital, MA USA
(author)
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Sawcer, Stephen JUniversity of Cambridge, England
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McCauley, Jacob LUniversity of Miami, FL USA
(author)
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Karolinska InstitutetUniversity of Miami, FL USA
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In:Nature genetics: Springer Science and Business Media LLC45:11, s. 1353-601546-17181061-4036
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Beecham, Ashley ...
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Nature genetics
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University of Gothenburg
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Karolinska Institutet
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