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  • Paciaroni, M. (author)

Prediction of Early Recurrent Thromboembolic Event and Major Bleeding in Patients With Acute Stroke and Atrial Fibrillation by a Risk Stratification Schema The ALESSA Score Study

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • Ovid Technologies (Wolters Kluwer Health),2017

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/253331
  • https://gup.ub.gu.se/publication/253331URI
  • https://doi.org/10.1161/strokeaha.116.015770DOI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background and Purposes-This study was designed to derive and validate a score to predict early ischemic events and major bleedings after an acute ischemic stroke in patients with atrial fibrillation. Methods-The derivation cohort consisted of 854 patients with acute ischemic stroke and atrial fibrillation included in prospective series between January 2012 and March 2014. Older age (hazard ratio 1.06 for each additional year; 95% confidence interval, 1.00-1.11) and severe atrial enlargement (hazard ratio, 2.05; 95% confidence interval, 1.08-2.87) were predictors for ischemic outcome events (stroke, transient ischemic attack, and systemic embolism) at 90 days from acute stroke. Small lesions (1.5 cm) were inversely correlated with both major bleeding (hazard ratio, 0.39; P=0.03) and ischemic outcome events (hazard ratio, 0.55; 95% confidence interval, 0.30-1.00). We assigned to age 80 years 2 points and between 70 and 79 years 1 point; ischemic index lesion >1.5 cm, 1 point; severe atrial enlargement, 1 point (ALESSA score). A logistic regression with the receiver-operating characteristic graph procedure (C statistic) showed an area under the curve of 0.697 (0.632-0.763; P=0.0001) for ischemic outcome events and 0.585 (0.493-0.678; P=0.10) for major bleedings. Results-The validation cohort consisted of 994 patients included in prospective series between April 2014 and June 2016. Logistic regression with the receiver-operating characteristic graph procedure showed an area under the curve of 0.646 (0.529-0.763; P=0.009) for ischemic outcome events and 0.407 (0.275-0.540; P=0.14) for hemorrhagic outcome events. Conclusions-In acute stroke patients with atrial fibrillation, high ALESSA scores were associated with a high risk of ischemic events but not of major bleedings.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Agnelli, G. (author)
  • Caso, V. (author)
  • Tsivgoulis, G. (author)
  • Furie, K. L. (author)
  • Tadi, P. (author)
  • Becattini, C. (author)
  • Falocci, N. (author)
  • Zedde, M. (author)
  • Abdul-Rahim, A. H. (author)
  • Lees, K. R. (author)
  • Alberti, A. (author)
  • Venti, M. (author)
  • Acciarresi, M. (author)
  • D'Amore, C. (author)
  • Mosconi, M. G. (author)
  • Cimini, L. A. (author)
  • Procopio, A. (author)
  • Bovi, P. (author)
  • Carletti, M. (author)
  • Rigatelli, A. (author)
  • Cappellari, M. (author)
  • Putaala, J. (author)
  • Tomppo, L. (author)
  • Tatlisumak, TurgutGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xtatlt (author)
  • Bandini, F. (author)
  • Marcheselli, S. (author)
  • Pezzini, A. (author)
  • Poli, L. (author)
  • Padovani, A. (author)
  • Masotti, L. (author)
  • Vannucchi, V. (author)
  • Sohn, S. I. (author)
  • Lorenzini, G. (author)
  • Tassi, R. (author)
  • Guideri, F. (author)
  • Acampa, M. (author)
  • Martini, G. (author)
  • Ntaios, G. (author)
  • Karagkiozi, E. (author)
  • Athanasakis, G. (author)
  • Makaritsis, K. (author)
  • Vadikolias, K. (author)
  • Liantinioti, C. (author)
  • Chondrogianni, M. (author)
  • Mumoli, N. (author)
  • Consoli, D. (author)
  • Galati, F. (author)
  • Sacco, S. (author)
  • Carolei, A. (author)
  • Tiseo, C. (author)
  • Corea, F. (author)
  • Ageno, W. (author)
  • Bellesini, M. (author)
  • Colombo, G. (author)
  • Silvestrelli, G. (author)
  • Ciccone, A. (author)
  • Scoditti, U. (author)
  • Denti, L. (author)
  • Mancuso, M. (author)
  • Maccarrone, M. (author)
  • Orlandi, G. (author)
  • Giannini, N. (author)
  • Gialdini, G. (author)
  • Tassinari, T. (author)
  • De Lodovici, M. L. (author)
  • Bono, G. (author)
  • Rueckert, C. (author)
  • Baldi, A. (author)
  • D'Anna, S. (author)
  • Toni, D. (author)
  • Letteri, F. (author)
  • Giuntini, M. (author)
  • Lotti, E. M. (author)
  • Flomin, Y. (author)
  • Pieroni, A. (author)
  • Kargiotis, O. (author)
  • Karapanayiotides, T. (author)
  • Monaco, S. (author)
  • Baronello, M. M. (author)
  • Csiba, L. (author)
  • Szabo, L. (author)
  • Chiti, A. (author)
  • Giorli, E. (author)
  • Del Sette, M. (author)
  • Imberti, D. (author)
  • Zabzuni, D. (author)
  • Doronin, B. (author)
  • Volodina, V. (author)
  • Michel, P. (author)
  • Vanacker, P. (author)
  • Barlinn, K. (author)
  • Pallesen, L. P. (author)
  • Kepplinger, J. (author)
  • Bodechtel, U. (author)
  • Gerber, J. (author)
  • Deleu, D. (author)
  • Melikyan, G. (author)
  • Ibrahim, F. (author)
  • Akhtar, N. (author)
  • Gourbali, V. (author)
  • Yaghi, S. (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)

Related titles

  • In:Stroke: Ovid Technologies (Wolters Kluwer Health)48:3, s. 726-7320039-24991524-4628

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  • Stroke (Search for host publication in LIBRIS)

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By the author/editor
Paciaroni, M.
Agnelli, G.
Caso, V.
Tsivgoulis, G.
Furie, K. L.
Tadi, P.
show more...
Becattini, C.
Falocci, N.
Zedde, M.
Abdul-Rahim, A. ...
Lees, K. R.
Alberti, A.
Venti, M.
Acciarresi, M.
D'Amore, C.
Mosconi, M. G.
Cimini, L. A.
Procopio, A.
Bovi, P.
Carletti, M.
Rigatelli, A.
Cappellari, M.
Putaala, J.
Tomppo, L.
Tatlisumak, Turg ...
Bandini, F.
Marcheselli, S.
Pezzini, A.
Poli, L.
Padovani, A.
Masotti, L.
Vannucchi, V.
Sohn, S. I.
Lorenzini, G.
Tassi, R.
Guideri, F.
Acampa, M.
Martini, G.
Ntaios, G.
Karagkiozi, E.
Athanasakis, G.
Makaritsis, K.
Vadikolias, K.
Liantinioti, C.
Chondrogianni, M ...
Mumoli, N.
Consoli, D.
Galati, F.
Sacco, S.
Carolei, A.
Tiseo, C.
Corea, F.
Ageno, W.
Bellesini, M.
Colombo, G.
Silvestrelli, G.
Ciccone, A.
Scoditti, U.
Denti, L.
Mancuso, M.
Maccarrone, M.
Orlandi, G.
Giannini, N.
Gialdini, G.
Tassinari, T.
De Lodovici, M. ...
Bono, G.
Rueckert, C.
Baldi, A.
D'Anna, S.
Toni, D.
Letteri, F.
Giuntini, M.
Lotti, E. M.
Flomin, Y.
Pieroni, A.
Kargiotis, O.
Karapanayiotides ...
Monaco, S.
Baronello, M. M.
Csiba, L.
Szabo, L.
Chiti, A.
Giorli, E.
Del Sette, M.
Imberti, D.
Zabzuni, D.
Doronin, B.
Volodina, V.
Michel, P.
Vanacker, P.
Barlinn, K.
Pallesen, L. P.
Kepplinger, J.
Bodechtel, U.
Gerber, J.
Deleu, D.
Melikyan, G.
Ibrahim, F.
Akhtar, N.
Gourbali, V.
Yaghi, S.
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Neurosciences
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
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and Cardiac and Card ...
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Stroke
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University of Gothenburg

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