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Inflammation, Amylo...
Inflammation, Amyloid, and Atrophy in The Aging Brain: Relationships with Longitudinal Changes in Cognition.
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Sala-Llonch, Roser (author)
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Idland, Ane-Victoria (author)
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Borza, Tom (author)
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Watne, Leiv Otto (author)
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Wyller, Torgeir Bruun (author)
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Brækhus, Anne (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Walhovd, Kristine Beate (author)
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Martin Fjell, Anders (author)
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(creator_code:org_t)
- 2017
- 2017
- English.
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In: Journal of Alzheimer's disease : JAD. - 1875-8908. ; 58:3, s. 829-840
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Amyloid deposition occurs in aging, even in individuals free from cognitive symptoms, and is often interpreted as preclinical Alzheimer's disease (AD) pathophysiology. YKL-40 is a marker of neuroinflammation, being increased in AD, and hypothesized to interact with amyloid-β (Aβ) in causing cognitive decline early in the cascade of AD pathophysiology. Whether and how Aβ and YKL-40 affect brain and cognitive changes in cognitively healthy older adults is still unknown. We studied 89 participants (mean age: 73.1 years) with cerebrospinal fluid samples at baseline, and both MRI and cognitive assessments from two time-points separated by two years. We tested how baseline levels of Aβ42 and YKL-40 correlated with changes in cortical thickness and cognition. Thickness change correlated with Aβ42 only in Aβ42+ participants (<600 pg/mL, n=27) in the left motor and premotor cortices. Aβ42 was unrelated to cognitive change. Increased YKL-40 was associated with less preservation of scores on the animal naming test in the total sample (r=-0.28, p=0.012) and less preservation of a score reflecting global cognitive function for Aβ42+ participants (r=-0.58, p=0.004). Our results suggest a role for inflammation in brain atrophy and cognitive changes in cognitively normal older adults, which partly depended on Aβ accumulation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Aging
- biomarkers
- cerebrospinal fluid
- cognition
- cortical thickness
- inflammation
- memory
- MRI
- YKL-40
Publication and Content Type
- ref (subject category)
- art (subject category)
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Sala-Llonch, Ros ...
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Idland, Ane-Vict ...
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Borza, Tom
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Watne, Leiv Otto
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Wyller, Torgeir ...
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Brækhus, Anne
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show more...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Walhovd, Kristin ...
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Martin Fjell, An ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Alzhe ...
- By the university
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University of Gothenburg