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Attenuated Low-Grad...
Attenuated Low-Grade Inflammation Following Long-Term Dietary Intervention in Postmenopausal Women with Obesity
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- Blomquist, Caroline (author)
- Umeå universitet,Medicin
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- Alvehus, Malin (author)
- Umeå universitet,Medicin
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- Burén, Jonas (author)
- Umeå universitet,Medicin
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- Ryberg, Mats (author)
- Umeå universitet,Medicin
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- Larsson, Christel, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kost- och idrottsvetenskap,Department of Food and Nutrition, and Sport Science,Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden.
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- Lindahl, Bernt (author)
- Umeå universitet,Yrkes- och miljömedicin
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- Mellberg, Caroline (author)
- Umeå universitet,Medicin
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- Söderström, Ingegerd (author)
- Umeå universitet,Medicin
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- Chorell, Elin (author)
- Umeå universitet,Medicin
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- Olsson, Tommy (author)
- Umeå universitet,Medicin
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(creator_code:org_t)
- 2017-04-25
- 2017
- English.
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In: Obesity. - : Wiley. - 1930-7381 .- 1930-739X. ; 25:5, s. 892-900
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- ObjectiveAbdominal fat accumulation after menopause is associated with low-grade inflammation and increased risk of metabolic disorders. Effective long-term lifestyle treatment is therefore needed. MethodsSeventy healthy postmenopausal women (age 605.6 years) with BMI 32.55.5 were randomized to a Paleolithic-type diet (PD) or a prudent control diet (CD) for 24 months. Blood samples and fat biopsies were collected at baseline, 6 months, and 24 months to analyze inflammation-related parameters. ResultsAndroid fat decreased significantly more in the PD group (P=0.009) during the first 6 months with weight maintenance at 24 months in both groups. Long-term significant effects (P<0.001) on adipose gene expression were found for toll-like receptor 4 (decreased at 24 months) and macrophage migration inhibitory factor (increased at 24 months) in both groups. Serum interleukin 6 (IL-6) and tumor necrosis factor levels were decreased at 24 months in both groups (P<0.001) with a significant diet-by-time interaction for serum IL-6 (P=0.022). High-sensitivity C-reactive protein was decreased in the PD group at 24 months (P=0.001). ConclusionsA reduction of abdominal obesity in postmenopausal women is linked to specific changes in inflammation-related adipose gene expression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- paleolithic-type diet
- adipose-tissue
- weight-loss
- insulin-resistance
- metabolic syndrome
- randomized-trial
- glucose-tolerance
- mononuclear-cells
- messenger-rna
- life-style
- Endocrinology & Metabolism
- Nutrition & Dietetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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Obesity
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- By the author/editor
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Blomquist, Carol ...
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Alvehus, Malin
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Burén, Jonas
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Ryberg, Mats
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Larsson, Christe ...
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Lindahl, Bernt
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show more...
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Mellberg, Caroli ...
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Söderström, Inge ...
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Chorell, Elin
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Olsson, Tommy
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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Obesity
- By the university
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University of Gothenburg
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Umeå University