Search: WFRF:(Larsson Christel) >
Attenuated Low-Grad...
Attenuated Low-Grade Inflammation Following Long-Term Dietary Intervention in Postmenopausal Women with Obesity
-
- Blomquist, Caroline (author)
- Umeå universitet,Medicin
-
- Alvehus, Malin (author)
- Umeå universitet,Medicin
-
- Burén, Jonas (author)
- Umeå universitet,Medicin
-
show more...
-
- Ryberg, Mats (author)
- Umeå universitet,Medicin
-
- Larsson, Christel, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kost- och idrottsvetenskap,Department of Food and Nutrition, and Sport Science,Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden.
-
- Lindahl, Bernt (author)
- Umeå universitet,Yrkes- och miljömedicin
-
- Mellberg, Caroline (author)
- Umeå universitet,Medicin
-
- Söderström, Ingegerd (author)
- Umeå universitet,Medicin
-
- Chorell, Elin (author)
- Umeå universitet,Medicin
-
- Olsson, Tommy (author)
- Umeå universitet,Medicin
-
show less...
-
(creator_code:org_t)
- 2017-04-25
- 2017
- English.
-
In: Obesity. - : Wiley. - 1930-7381 .- 1930-739X. ; 25:5, s. 892-900
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- ObjectiveAbdominal fat accumulation after menopause is associated with low-grade inflammation and increased risk of metabolic disorders. Effective long-term lifestyle treatment is therefore needed. MethodsSeventy healthy postmenopausal women (age 605.6 years) with BMI 32.55.5 were randomized to a Paleolithic-type diet (PD) or a prudent control diet (CD) for 24 months. Blood samples and fat biopsies were collected at baseline, 6 months, and 24 months to analyze inflammation-related parameters. ResultsAndroid fat decreased significantly more in the PD group (P=0.009) during the first 6 months with weight maintenance at 24 months in both groups. Long-term significant effects (P<0.001) on adipose gene expression were found for toll-like receptor 4 (decreased at 24 months) and macrophage migration inhibitory factor (increased at 24 months) in both groups. Serum interleukin 6 (IL-6) and tumor necrosis factor levels were decreased at 24 months in both groups (P<0.001) with a significant diet-by-time interaction for serum IL-6 (P=0.022). High-sensitivity C-reactive protein was decreased in the PD group at 24 months (P=0.001). ConclusionsA reduction of abdominal obesity in postmenopausal women is linked to specific changes in inflammation-related adipose gene expression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- paleolithic-type diet
- adipose-tissue
- weight-loss
- insulin-resistance
- metabolic syndrome
- randomized-trial
- glucose-tolerance
- mononuclear-cells
- messenger-rna
- life-style
- Endocrinology & Metabolism
- Nutrition & Dietetics
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Obesity
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Blomquist, Carol ...
-
Alvehus, Malin
-
Burén, Jonas
-
Ryberg, Mats
-
Larsson, Christe ...
-
Lindahl, Bernt
-
show more...
-
Mellberg, Caroli ...
-
Söderström, Inge ...
-
Chorell, Elin
-
Olsson, Tommy
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Nutrition and Di ...
- Articles in the publication
-
Obesity
- By the university
-
University of Gothenburg
-
Umeå University