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HIV-1 transmission ...
HIV-1 transmission between MSM and heterosexuals, and increasing proportions of circulating recombinant forms in the Nordic Countries
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- Esbjornsson, J. (författare)
- Karolinska Inst, Sweden; Univ Oxford, England; Katholieke Univ Leuven, Belgium
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- Mild, M. (författare)
- Department of Microbiology, Public Health Agency of Sweden, Stockholm, Sweden
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- Audelin, A. (författare)
- Karolinska Institutet,Department of Microbiological Diagnostics and Virology, Statens Serum Institut, Copenhagen, Denmark
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- Fonager, J. (författare)
- Department of Microbiological Diagnostics and Virology, Statens Serum Institut, Copenhagen, Denmark
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- Skar, Helena (författare)
- Linköpings universitet,Medie- och Informationsteknik,Tekniska fakulteten
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- Jorgensen, L. B. (författare)
- Department of Microbiological Diagnostics and Virology, Statens Serum Institut, Copenhagen, Denmark
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- Liitsola, K. (författare)
- Department of Infectious Diseases, National Institute for Health and Welfare, Helsinki, Finland
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- Bjorkman, P. (författare)
- Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
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- Bratt, G. (författare)
- Karolinska Institutet,Department of Clinical Science and Education, Venhalsan, Stockholm South General Hospital, Stockholm, Sweden
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- Gisslén, Magnus, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Department of Infectious Diseases, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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- Sonnerborg, A. (författare)
- Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden; Division of Clinical Microbiology, Karolinska Institute, Stockholm, Sweden; Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden
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- Nielsen, C. (författare)
- Department of Microbiological Diagnostics and Virology, Statens Serum Institut, Copenhagen, Denmark
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- Medstrand, P. (författare)
- Department of Translational Medicine, Lund University, Malmö, Sweden
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- Albert, J. (författare)
- Karolinska Institutet,Department of Microbiology Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden; Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden
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(creator_code:org_t)
- 2016-04-27
- 2016
- Engelska.
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Ingår i: Virus Evolution. - : Oxford University Press (OUP). - 2057-1577. ; 2:1
- Relaterad länk:
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https://academic.oup...
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https://liu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Increased knowledge about HIV-1 transmission dynamics in different transmission groups and geographical regions is fundamental for assessing and designing prevention efforts against HIV-1 spread. Since the first reported cases of HIV infection during the early 1980s, the HIV-1 epidemic in the Nordic countries has been dominated by HIV-1 subtype B and MSM transmission. HIV-1 pol sequences and clinical data of 51 per cent of all newly diagnosed HIV-1 infections in Sweden, Denmark, and Finland in the period 2000-2012 (N = 3,802) were analysed together with a large reference sequence dataset (N = 4,537) by trend analysis and phylogenetics. Analysis of the eight dominating subtypes and CRFs in the Nordic countries (A, B, C, D, G, CRF01_AE, CRF02_AG, and CRF06_cpx) showed that the subtype B proportion decreased while the CRF proportion increased over the study period. A majority (57 per cent) of the Nordic sequences formed transmission clusters, with evidence of mixing both geographically and between transmission groups. Detailed analyses showed multiple occasions of transmissions from MSM to heterosexuals and that active transmission clusters more often involved single than multiple Nordic countries. The strongest geographical link was between Denmark and Sweden. Finally, Denmark had a larger proportion of heterosexual domestic spread of HIV-1 subtype B (75 per cent) compared with Sweden (49 per cent) and Finland (57 per cent). We describe different HIV-1 transmission patterns between countries and transmission groups in a large geographical region. Our results may have implications for public health interventions in targeting HIV-1 transmission networks and identifying where to introduce such interventions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- HIV-1
- subtype
- transmission
- molecular epidemiology
- phylogeny
- replicative fitness
- drug-users
- subtype-a
- epidemic
- men
- crf02-ag
- sex
- determinants
- netherlands
- resistance
- Virology
- HIV-1; subtype; transmission; molecular epidemiology; phylogeny
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Esbjornsson, J.
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Mild, M.
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Audelin, A.
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Fonager, J.
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Skar, Helena
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Jorgensen, L. B.
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visa fler...
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Liitsola, K.
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Bjorkman, P.
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Bratt, G.
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Gisslén, Magnus, ...
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Sonnerborg, A.
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Nielsen, C.
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Medstrand, P.
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Albert, J.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Mikrobiologi ino ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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Virus Evolution
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet
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Linköpings universitet