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Phagocytosis follow...
Phagocytosis following translocation of the neutrophil b-cytochrome from the specific granule to the plasma membrane is associated with an increased leakage of reactive oxygen species.
- Article/chapterEnglish1992
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LIBRIS-ID:oai:gup.ub.gu.se/253944
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https://gup.ub.gu.se/publication/253944URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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The effect of neutrophil b-cytochrome translocation on the respiratory burst activation generated during phagocytosis of yeast particles was investigated. Secretion of neutrophil specific granules was induced by the calcium ionophore ionomycin prior to phagocytosis. The secretory process is associated with a translocation from the specific granules to the plasma membrane of the respiratory burst b-cytochrome. Respiratory burst activity was measured as release of hydrogen peroxide in the absence of azide (extracellular leakage) and in the presence of azide (total production). The subcellular localization of the b-cytochrome was found to affect the extracellular release of hydrogen peroxide in that a plasma membrane localization was associated with a significantly increased release during phagocytosis. It should be pointed out, however, that most of the hydrogen peroxide, both in control and in ionomycin-treated cells, is produced intracellularly, probably in the phagosomes.
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Karlsson, Anna,1967Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research(Swepub:gu)xkannb
(author)
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Follin, P
(author)
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Sjölin, C
(author)
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Dahlgren, Claes,1949Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Medical Microbiology/Immunology,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research(Swepub:gu)xdahcl
(author)
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Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning
(creator_code:org_t)
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In:Scandinavian journal of immunology36:6, s. 885-910300-9475
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