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Localization of Sta...
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Hanssen, A. M.UiT Arctic University of Norway, Norway
(författare)
Localization of Staphylococcus aureus in tissue from the nasal vestibule in healthy carriers
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-04-05
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Springer Science and Business Media LLC,2017
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/254049
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https://gup.ub.gu.se/publication/254049URI
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https://doi.org/10.1186/s12866-017-0997-3DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:135658300URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-137392URI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|Norwegian Research Council (NFR) [191, 264]; Northern Norway Regional Health Authority (Helse Nord RHF) [SFP877-09]; Miljostotte [MIL963-10]; UiT The Arctic University of Norway
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Background: Colonization of the body is an important step in Staphylococcus aureus infection. S. aureus colonizes skin and mucous membranes in humans and several animal species. One important ecological niche of S. aureus is the anterior nares. More than 60% of the S. aureus in the nose are found in vestibulum nasi. Our aim was to describe the localization of S. aureus in nasal tissue from healthy carriers. Methods: Punch skin biopsies were taken from vestibulum nasi from healthy volunteers (S. aureus carriers and non-/intermittent carriers, n = 39) attending the population-based Tromso 6 study. The tissue samples were processed as frozen sections before immunostaining with a specific S. aureus antibody, and finally evaluated by a confocal laser-scanning microscope. Results: Our results suggest that S. aureus colonize both the upper and lower layers of the epidermis within the nasal epithelium of healthy individuals. The number of S. aureus in epidermis was surprisingly low. Intracellular localization of S. aureus in nasal tissue from healthy individuals was also detected. Conclusions: Knowledge of the exact localization of S. aureus in nasal tissue is important for the understanding of the host responses against S. aureus. Our results may have consequences for the eradication strategy of S. aureus in carriers, and further work can provide us with tools for targeted prevention of S. aureus colonisation and infection.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kindlund, Bert,1969Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,University of Gothenburg, Sweden(Swepub:gu)xkinbe
(författare)
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Stenklev, N. C.UiT Arctic University of Norway, Norway
(författare)
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Furberg, A. S.University Hospital North Norway, Norway; UiT Arctic University of Norway, Norway
(författare)
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Fismen, S.University Hospital North Norway, Norway
(författare)
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Slind Olsen, RenateLinköpings universitet,Karolinska Institutet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Department Lab Med, Sweden(Swepub:liu)rensl63
(författare)
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Johannessen, M.UiT Arctic University of Norway, Norway
(författare)
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Sollid, J. U. E.UiT Arctic University of Norway, Norway
(författare)
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UiT Arctic University of Norway, NorwayInstitutionen för biomedicin, avdelningen för mikrobiologi och immunologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:BMC Microbiology: Springer Science and Business Media LLC171471-2180
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