id:"swepub:oai:gup.ub.gu.se/254251"
Search: id:"swepub:oai:gup.ub.gu.se/254251" > Fibrinolysis inhibi...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Rylander, A. C. J. (author)
Fibrinolysis inhibitors in plaque stability: a morphological association of PAI-1 and TAFI in advanced carotid plaque
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- Elsevier BV,2017
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/254251
- https://gup.ub.gu.se/publication/254251URI
- https://doi.org/10.1111/jth.13641DOI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Background: Fibrinolysis plays an important role in destabilization of atherosclerotic plaques and is tightly regulated by specific inhibitors. Objective: The fibrinolysis inhibitors plasminogen activator inhibitor type-1 (PAI-1) and thrombin-activatable fibrinolysis inhibitor (TAFI) were quantified and described in the morphological context of advanced carotid plaques American Heart Association VI-VIII to elucidate their role in plaque stability. Methods: Immunohistochemistry in serial sections along the longitudinal axis of endarterectomies from patients with symptomatic carotid stenosis (n = 19) were studied using an antibody specific for free PAI-1 (I205), an antibody with high affinity for TAFI/TAFIa (CP17) and established antibodies for smooth muscle cells (alpha-actin), endothelial cells (von Willebrand factor [VWF]), macrophages (CD68) and platelets (CD42). Results: PAI-1 and TAFI show a specific distribution in these advanced plaques with a maximum corresponding to the internal carotid artery (ICA). Free PAI-1 was mainly detected in macrophages and in intravascular thrombi, and TAFI in endothelial cells (ECs) but also macrophages. The one-way ANOVA analysis with Bonferroni's correction showed a significant increase of macrophages and ECs, TAFI and PAI-1 in areas with high neovascularization in endarterectomy sections corresponding to ICA. High Spearman factors for TAFI, PAI-1 and VWF indicate neovascularization as the main source of plasma proteins, transported by platelets into the atheroma (PAI-1) or expressed by ECs (TAFI). CD68 was highly associated with VWF, PAI-1 and especially TAFI, underlining the role of macrophages in fibrinolytic activity and inflammation. Conclusion: The abundance of free PAI-1 and TAFI in the plaque may inhibit plasmin generation and thereby counteract plaque destabilization by fibrinolysis, cell migration and inflammation.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- Endarterectomy
- fibrinolysis
- immuno histochemistry
- Plasminogen Activator Inhibitor 1
- thrombin-
- TISSUE-PLASMINOGEN ACTIVATOR
- ATHEROSCLEROTIC LESIONS
- ISCHEMIC-STROKE
- ENDOTHELIAL FUNCTION
- CARBOXYPEPTIDASE-U
- CORONARY-ARTERIES
- PLASMA-LEVELS
- IN-VITRO
- THROMBIN
- EXPRESSION
Added entries (persons, corporate bodies, meetings, titles ...)
- Lindgren, A. (author)
- Deinum, J. (author)
- Bergström, Göran,1964Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xbgort (author)
- Bottcher, G. (author)
- Kalies, I. (author)
- Wahlander, K. (author)
- Göteborgs universitetInstitutionen för medicin (creator_code:org_t)
Related titles
- In:Journal of Thrombosis and Haemostasis: Elsevier BV15:4, s. 758-7691538-79331538-7836
Internet link
Find in a library
- Journal of Thrombosis and Haemostasis (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Rylander, A. C. ...
- Lindgren, A.
- Deinum, J.
- Bergström, Göran ...
- Bottcher, G.
- Kalies, I.
- show more...
- Wahlander, K.
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cardiac and Card ...
- Articles in the publication
- Journal of Throm ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
