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  • Andersson, Tommy,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden,Orebro Univ, Fac Hlth, Dept Cardiol, Orebro, Sweden. (författare)

Patients with atrial fibrillation and outcomes of cerebral infarction in those with treatment of warfarin versus no warfarin with references to CHA(2)DS(2)-VASc score, age and sex - A Swedish nationwide observational study with 48 433 patients

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017-05-04
  • Public Library of Science (PLoS),2017

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/254638
  • https://gup.ub.gu.se/publication/254638URI
  • https://doi.org/10.1371/journal.pone.0176846DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-57914URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-325339URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Research Committee of Örebro University  0LL 2012-265231 AstraZeneca RD Mölndal  Örebro Heart Foundation 
  • Aims There is controversy in the guidelines as to whether patients with atrial fibrillation and a low risk of stroke should be treated with anticoagulation, especially those with a CHA(2)DS(2)-VASc score of 1 point. In a retrospective, nationwide cohort study, we used the Swedish National Patient Registry, the National Prescribed Drugs Registry, the Swedish Registry of Education and the Population and Housing Census Registry. 48 433 patients were identified between 1 January 2006 and 31 December 2008 with incident atrial fibrillation who were divided in age categories, sex and a CHA(2)DS(2)-VASc score of 0, 1, 2 and >= 3 and they were included in a time-varying analysis of warfarin treatment versus no treatment. The primary end-point was cerebral infarction and stroke, and patients were followed until 31 December 2009. Patients with 1 point from the CHA(2)DS(2)-VASc score showed the following adjusted hazard ratios (HR) with a 95% confidence interval: men 65-74 years 0.46 (0.25-0.83), men < 65 years 1.11 (0.56-2.23) and women < 65 years 2.13 (0.94-4.82), where HR < 1 indicates protection with warfarin. In patients < 65 years and 2 points, HR in men was 0.35 (0.18-0.69) and in women 1.84 (0.86-3.94) while, in women with at least 3 points, HR was 0.31 (0.16-0.59). In patients 65-74 years and 2 points, HR in men was 0.37 (0.23-0.59) and in women 0.39 ( 0.21-0.73). Categories including age >= 65 years or >= 3 points showed a statistically significant protection from warfarin. Our results support that treatment with anticoagulation may be considered in all patients with an incident atrial fibrillation diagnosis and an age of 65 years and older, i.e. also when the CHA(2)DS(2)-VASc score is 1.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Magnuson, A.Region Örebro län,Clinical Epidemiology and Biostatistics,Orebro Univ, Sch Med Sci, Clin Epidemiol & Biostat, Orebro, Sweden. (författare)
  • Bryngelsson, I. L.Region Örebro län,Department of Occupational and Environmental Medicine, Örebro University Hospital, Örebro, Sweden,Orebro Univ, Dept Occupat & Environm Med, Orebro, Sweden. (författare)
  • Fröbert, Ole,1964-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Cardiology, Örebro University Hospital, Örebro, Sweden,Orebro Univ, Fac Hlth, Dept Cardiol, Orebro, Sweden.(Swepub:oru)oft (författare)
  • Henriksson, Karin M.Uppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)karhe322 (författare)
  • Edvardsson, Nils,1942Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Sahlgrenska Academy at Sahlgrenska University Hospital, Göteborg, Sweden,Sahlgrens Univ Hosp, Sahlgrenska Acad, Gothenburg, Sweden.(Swepub:gu)xedvni (författare)
  • Poci, Dritan,1969-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden,Orebro Univ, Fac Hlth, Dept Cardiol, Orebro, Sweden.(Swepub:oru)dnpi (författare)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:PLoS ONE: Public Library of Science (PLoS)12:51932-6203

Internetlänk

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  • PLoS ONE (Sök värdpublikationen i LIBRIS)

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