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  • Graff, M.University of North Carolina (author)

Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-04-27
  • Public Library of Science (PLoS),2017

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/254836
  • https://gup.ub.gu.se/publication/254836URI
  • https://doi.org/10.1371/journal.pgen.1006528DOI
  • https://lup.lub.lu.se/record/057bd662-bc36-4f95-9de4-51eb11e3461aURI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:136007091URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-321624URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489425URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-137008URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by similar to 30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

Subject headings and genre

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  • Scott, R. A.University of Cambridge (author)
  • Justice, A. E.University of North Carolina (author)
  • Young, K. L.University of North Carolina,Wake Forest University (author)
  • Feitosa, M. F.University of Washington (author)
  • Barata, L.University of Washington (author)
  • Winkler, T. W.University of Regensburg,Harvard University (author)
  • Chu, A. Y.Brigham and Women's Hospital / Harvard Medical School (author)
  • Mahajan, A.University of Oxford (author)
  • Hadley, D.University College London (author)
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  • Qi, Q. B.Yeshiva University (author)
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  • Renström, FridaUmeå universitet,Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Enheten för biobanksforskning,Lund Univ, Genet & Mol Epidemiol Unit, Dept Clin Sci, Malmo, Sweden(Swepub:umu)frre0001 (author)
  • Quaye, L.King's College London (author)
  • Eicher, J. D.National Institutes of Health, United States (author)
  • Eriksson, JoelGothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xerjoe (author)
  • Cornelis, M.Harvard University,Northwestern University Feinberg School of Medicine,Brigham and Women's Hospital / Harvard Medical School (author)
  • Kutalik, Z.Lausanne University Hospital,Swiss Institute for Bioinformatics (SIB) (author)
  • Lim, E.Boston University (author)
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  • Zhao, W.University of Michigan (author)
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  • Ahmad, ShafqatLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-sta (author)
  • Marques-Vidal, P. M.Lausanne University Hospital (author)
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  • Smith, A. V.University of Iceland,Icelandic Heart Association (author)
  • Kumari, M.University of Essex (author)
  • Harder, M. N.University of Copenhagen (author)
  • Justesen, J. M.University of Copenhagen (author)
  • Kleber, M. E.Heidelberg University,Friedrich Schiller University Jena (author)
  • Hollensted, M.University of Copenhagen (author)
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  • Rivera, N. V.Karolinska Institutet (author)
  • Whitfield, J. B.QIMR Berghofer Medical Research Institute (author)
  • Zhao, J. H.University of Cambridge (author)
  • Stringham, H. M.University of Michigan (author)
  • Lyytikainen, L. P.Fimlab Laboratories,University of Tampere (author)
  • Huppertz, C.Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam (author)
  • Willemsen, G.Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam (author)
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  • Eriksson, JoelGothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xerjoe (author)
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  • Balkau, B. (author)
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  • Corre, T. (author)
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  • Dueker, N. (author)
  • Dorr, M. (author)
  • Ebeling, T. (author)
  • Eiriksdottir, G. (author)
  • Esko, T. (author)
  • Faul, J. D. (author)
  • Fu, M. (author)
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  • Glaser, S. (author)
  • Gong, J. (author)
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  • Jansson, John-Olov,1954Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xjanjo (author)
  • Jhun, M. A. (author)
  • Juonala, M. (author)
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  • Peyser, P. A. (author)
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  • Rawal, R. (author)
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  • Rose, L. M. (author)
  • Rudan, I. (author)
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  • Vandenput, Liesbeth,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xvanli (author)
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  • Wild, S. (author)
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  • Lemarchand, L. (author)
  • Gyllensten, UlfUppsala universitet,Medicinsk genetik och genomik(Swepub:uu)ulfgyll (author)
  • Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xohlcl (author)
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  • Polasek, O. (author)
  • Cucca, F. (author)
  • Hveem, K. (author)
  • Hartman, C. A. (author)
  • Tonjes, A. (author)
  • Bandinelli, S. (author)
  • Palmer, L. J. (author)
  • Kardia, S. L. R. (author)
  • Rauramaa, R. (author)
  • Sorensen, T. I. A. (author)
  • Tuomilehto, J. (author)
  • Salomaa, V. (author)
  • Penninx, Bwjh (author)
  • de Geus, E. J. C. (author)
  • Boomsma, D. I. (author)
  • Lehtimaki, T. (author)
  • Mangino, M. (author)
  • Laakso, M. (author)
  • Bouchard, C. (author)
  • Martin, N. G. (author)
  • Kuh, D. (author)
  • Liu, Y. M. (author)
  • Linneberg, A. (author)
  • Marz, W. (author)
  • Strauch, K. (author)
  • Kivimaki, M. (author)
  • Harris, T. B. (author)
  • Gudnason, V. (author)
  • Volzke, H. (author)
  • Qi, L. (author)
  • Jarvelin, M. R. (author)
  • Chambers, J. C. (author)
  • Kooner, J. S. (author)
  • Froguel, P. (author)
  • Kooperberg, C. (author)
  • Vollenweider, P. (author)
  • Hallmans, GöranUmeå universitet,Enheten för biobanksforskning(Swepub:umu)goha0001 (author)
  • Hansen, T. (author)
  • Pedersen, O. (author)
  • Metspalu, A. (author)
  • Wareham, N. J. (author)
  • Langenberg, C. (author)
  • Weir, D. R. (author)
  • Porteous, D. J. (author)
  • Boerwinkle, E. (author)
  • Chasman, D. I. (author)
  • Abecasis, G. R. (author)
  • Barroso, I. (author)
  • McCarthy, M. I. (author)
  • Frayling, T. M. (author)
  • O'Connell, J. R. (author)
  • van Duijn, C. M. (author)
  • Boehnke, M. (author)
  • Heid, I. M. (author)
  • Mohlke, K. L. (author)
  • Strachan, D. P. (author)
  • Fox, C. S. (author)
  • Liu, C. T. (author)
  • Hirschhorn, J. N. (author)
  • Klein, R. J. (author)
  • Johnson, A. D. (author)
  • Borecki, I. B. (author)
  • Franks, Paul W.Umeå universitet,Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University,Medicin,Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA ; Lund Univ, Genet & Mol Epidemiol Unit, Dept Clin Sci, Malmo, Sweden(Swepub:umu)pafr0003 (author)
  • North, K. E. (author)
  • Cupples, L. A. (author)
  • Loos, R. J. F. (author)
  • Kilpelainen, T. O. (author)
  • Charge Consortium; EPIC-InterAct Consortium; PAGE Consortium, Charge Consortium; EPIC-InterAct Consortium; PAGE Consortium (author)
  • Hayes, James E (author)
  • University of North CarolinaUniversity of Cambridge (creator_code:org_t)

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PLoS Genet
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University of Gothenburg
Lund University
Karolinska Institutet
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M_Graff
Graff, M.
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