id:"swepub:oai:gup.ub.gu.se/255027"
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- Choi, Y. (author)
Coordinated Regulation Among Progesterone, Prostaglandins, and EGF-Like Factors in Human Ovulatory Follicles
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- 2017-03-09
- The Endocrine Society,2017
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- LIBRIS-ID:oai:gup.ub.gu.se/255027
- https://gup.ub.gu.se/publication/255027URI
- https://doi.org/10.1210/jc.2016-3153DOI
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- Language:English
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- Context: In animal models, the luteinizing hormone surge increases progesterone (P4) and progesterone receptor (PGR), prostaglandins (PTGs), and epidermal growth factor (EGF)-like factors that play essential roles in ovulation. However, little is known about the expression, regulation, and function of these key ovulatory mediators in humans. Objective: To determine when and how these key ovulatory mediators are induced after the luteinizing hormone surge in human ovaries. Design and Participants: Timed periovulatory follicles were obtained from cycling women. Granulosa/lutein cells were collected from in vitro fertilization patients. Main Outcome Measures: The in vivo and in vitro expression of PGR, PTG synthases and transporters, and EGF-like factors were examined at the level of messenger RNA and protein. PGR binding to specific genes was assessed. P4 and PTGs in conditioned media were measured. Results: PGR, PTGS2, and AREG expressions dramatically increased in ovulatory follicles at 12 to 18 hours after human chorionic gonadotropin (hCG). In human granulosa/lutein cell cultures, hCG increased P4 and PTG production and the expression of PGR, specific PTG synthases and transporters, and EGF-like factors, mimicking in vivo expression patterns. Inhibitors for P4/PGR and EGF-signaling pathways reduced hCG-induced increases in PTG production and the expression of EGF-like factors. PGR bound to the PTGS2, PTGES, and SLCO2A1 genes. Conclusions: This report demonstrated the time-dependent induction of PGR, AREG, and PTGS2 in human periovulatory follicles. In vitro studies indicated that collaborative actions of P4/PGR and EGF signaling are required for hCG-induced increases in PTG production and potentiation of EGF signaling in human periovulatory granulosa cells.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
- bovine preovulatory follicles
- human chorionic-gonadotropin
- messenger-ribonucleic-acid
- human granulosa-cells
- endoperoxide
- synthase-2
- periovulatory interval
- growth-factors
- receptor
- expression
- inhibition
- Endocrinology & Metabolism
Added entries (persons, corporate bodies, meetings, titles ...)
- Wilson, K. (author)
- Hannon, P. R. (author)
- Rosewell, K. L. (author)
- Brännström, Mats,1958Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xbrmat (author)
- Akin, J. W. (author)
- Curry, T. E. (author)
- Jo, M. (author)
- Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi (creator_code:org_t)
Related titles
- In:Journal of Clinical Endocrinology & Metabolism: The Endocrine Society102:6, s. 1971-19820021-972X1945-7197
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