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Sulforaphane reduce...
Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes
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- Axelsson, Annika S. (author)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups
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- Tubbs, Emily (author)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups
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- Mecham, B. (author)
- Trialomics
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- Chacko, S. (author)
- Baylor College of Medicine
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- Nenonen, Hannah A. (author)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Molekylärgenetisk reproduktionsmedicin, Malmö,Reproduktionsmedicin, Malmö,Diabetes - Islet Patophysiology,Lund University Research Groups,Molecular genetic reproductive medicine, Malmö,Reproductive medicine, Malmö
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- Tang, Yunzhao (author)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups
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- Fahey, J. W. (author)
- Johns Hopkins University
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- Derry, J. M. J. (author)
- Sage Bionetworks
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- Wollheim, Claes B. (author)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,University of Geneva Medical School
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- Wierup, Nils (author)
- Lund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups
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- Haymond, M. W. (author)
- Baylor College of Medicine
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- Friend, Stephen H. (author)
- Sage Bionetworks
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- Mulder, Hindrik (author)
- Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups
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- Rosengren, Anders H., 1978 (author)
- University of Gothenburg,Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups,Sage Bionetworks
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2017
- 2017
- English.
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In: Science Translational Medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 9:394
- Related links:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- A potentially useful approach for drug discovery is to connect gene expression profiles of disease-affected tissues ("disease signatures") to drug signatures, but it remains to be shown whether it can be used to identify clinically relevant treatment options. We analyzed coexpression networks and genetic data to identify a disease signature for type 2 diabetes in liver tissue. By interrogating a library of 3800 drug signatures, we identified sulforaphane as a compound that may reverse the disease signature. Sulforaphane suppressed glucose production from hepatic cells by nuclear translocation of nuclear factor erythroid 2-related factor 2 (NRF2) and decreased expression of key enzymes in gluconeogenesis. Moreover, sulforaphane reversed the disease signature in the livers from diabetic animals and attenuated exaggerated glucose production and glucose intolerance by a magnitude similar to that of metformin. Finally, sulforaphane, provided as concentrated broccoli sprout extract, reduced fasting blood glucose and glycated hemoglobin (HbA1c) in obese patients with dysregulated type 2 diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- gene-expression
- insulin-resistance
- induced inhibition
- broccoli
- sprouts
- oxidative stress
- network analysis
- fatty liver
- in-vivo
- nrf2
- disease
- Cell Biology
- Research & Experimental Medicine
- hwarze pe
- 1985
- carcinogenesis
- v6
- p777
- fronzo ra
- 1989
- metabolism-clinical and experimental
- v38
- p387
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Axelsson, Annika ...
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Tubbs, Emily
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Mecham, B.
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Chacko, S.
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Nenonen, Hannah ...
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Tang, Yunzhao
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show more...
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Fahey, J. W.
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Derry, J. M. J.
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Wollheim, Claes ...
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Wierup, Nils
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Haymond, M. W.
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Friend, Stephen ...
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Mulder, Hindrik
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Rosengren, Ander ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Science Translat ...
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University of Gothenburg
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Lund University