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Polygenic transmiss...
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
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Weiner, D. J. (author)
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Wigdor, E. M. (author)
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Ripke, S. (author)
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show more...
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Walters, R. K. (author)
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Kosmicki, J. A. (author)
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Grove, J. (author)
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Samocha, K. E. (author)
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Goldstein, J. I. (author)
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Okbay, A. (author)
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Bybjerg-Grauholm, J. (author)
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Werge, T. (author)
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Hougaard, D. M. (author)
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Taylor, J. (author)
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Skuse, D. (author)
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Devlin, B. (author)
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Anney, R. (author)
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- Sanders, S. J. (author)
- Karolinska Institutet
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Bishop, S. (author)
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Mortensen, P. B. (author)
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Borglum, A. D. (author)
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Smith, G. D. (author)
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Daly, M. J. (author)
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Robinson, E. B. (author)
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Baekvad-Hansen, M. (author)
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Dumont, A. (author)
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Hansen, C. (author)
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Hansen, T. F. (author)
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Howrigan, D. (author)
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- Mattheisen, M. (author)
- Karolinska Institutet
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Moran, J. (author)
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Mors, O. (author)
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Nordentoft, M. (author)
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Norgaard-Pedersen, B. (author)
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Poterba, T. (author)
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Poulsen, J. (author)
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Stevens, C. (author)
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Anttila, V. (author)
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Holmans, P. (author)
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Huang, H. L. (author)
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Klei, L. (author)
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Lee, P. H. (author)
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Medland, S. E. (author)
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Neale, B. (author)
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Weiss, L. A. (author)
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Zwaigenbaum, L. (author)
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Yu, T. W. (author)
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Wittemeyer, K. (author)
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Willsey, A. J. (author)
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Wijsman, E. M. (author)
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Wassink, T. H. (author)
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Waltes, R. (author)
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Walsh, C. A. (author)
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Wallace, S. (author)
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Vorstman, J. A. S. (author)
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Vieland, V. J. (author)
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Vicente, A. M. (author)
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van Engeland, H. (author)
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Tsang, K. (author)
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Thompson, A. P. (author)
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Szatmari, P. (author)
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Svantesson, O. (author)
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- Steinberg, S. (author)
- Karolinska Institutet
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Stefansson, K. (author)
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Stefansson, H. (author)
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State, M. W. (author)
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Soorya, L. (author)
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Silagadze, T. (author)
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Scherer, S. W. (author)
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Schellenberg, G. D. (author)
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Sandin, S. (author)
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Saemundsen, E. (author)
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Rouleau, G. A. (author)
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Roge, B. (author)
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Roeder, K. (author)
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Roberts, W. (author)
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Reichert, J. (author)
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Reichenberg, A. (author)
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Rehnstrom, K. (author)
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Regan, R. (author)
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Poustka, F. (author)
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Poultney, C. S. (author)
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Piven, J. (author)
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Pinto, D. (author)
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Pericak-Vance, M. A. (author)
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Pejovic-Milovancevic, M. (author)
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Pedersen, M. G. (author)
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Pedersen, C. B. (author)
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Paterson, A. D. (author)
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Parr, J. R. (author)
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Pagnamenta, A. T. (author)
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Oliveira, G. (author)
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Nurnberger, J. I. (author)
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Nordentoft, M. (author)
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Murtha, M. T. (author)
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Mouga, S. (author)
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Mors, O. (author)
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Morrow, E. M. (author)
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De Luca, D. M. (author)
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Monaco, A. P. (author)
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Minshew, N. (author)
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Merikangas, A. (author)
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McMahon, W. M. (author)
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McGrew, S. G. (author)
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Mattheisen, M. (author)
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Martsenkovsky, I. (author)
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Martin, D. M. (author)
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Mane, S. M. (author)
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Magnusson, P. (author)
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Magalhaes, T. (author)
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Maestrini, E. (author)
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Lowe, J. K. (author)
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Lord, C. (author)
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Levitt, P. (author)
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Martin, C. L. (author)
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Ledbetter, D. H. (author)
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Leboyer, M. (author)
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Le Couteur, A. S. (author)
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Ladd-Acosta, C. (author)
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Kolevzon, A. (author)
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Klauck, S. M. (author)
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Jacob, S. (author)
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Iliadou, B. (author)
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Hultman, C. M. (author)
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Hertz-Picciotto, I. (author)
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Hendren, R. (author)
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Hansen, C. S. (author)
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Haines, J. L. (author)
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Guter, S. J. (author)
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Grice, D. E. (author)
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Green, J. M. (author)
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Green, A. (author)
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Goldberg, A. P. (author)
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- Gillberg, Christopher, 1950 (author)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre
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Gilbert, J. (author)
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Gallagher, L. (author)
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Freitag, C. M. (author)
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Fombonne, E. (author)
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Folstein, S. E. (author)
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Fernandez, B. (author)
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Fallin, M. D. (author)
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Ercan-Sencicek, A. G. (author)
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Ennis, S. (author)
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Duque, F. (author)
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Duketis, E. (author)
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Delorme, R. (author)
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De Rubeis, S. (author)
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De Jonge, M. V. (author)
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Dawson, G. (author)
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Cuccaro, M. L. (author)
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Correia, C. T. (author)
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Conroy, J. (author)
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Conceicao, I. C. (author)
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Chiocchetti, A. G. (author)
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Celestino-Soper, P. B. S. (author)
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Casey, J. (author)
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Cantor, R. M. (author)
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Cafe, C. (author)
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Brennan, S. (author)
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Bourgeron, T. (author)
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Bolton, P. F. (author)
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Bolte, S. (author)
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Bolshakova, N. (author)
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Betancur, C. (author)
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Bernier, R. (author)
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Beaudet, A. L. (author)
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Battaglia, A. (author)
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Bal, V. H. (author)
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Baird, G. (author)
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Bailey, A. J. (author)
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Baekvad-Hansen, M. (author)
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Bader, J. S. (author)
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Bacchelli, E. (author)
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Anagnostou, E. (author)
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Amaral, D. (author)
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Almeida, J. (author)
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Buxbaum, J. D. (author)
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Chakravarti, A. (author)
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Cook, E. H. (author)
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Coon, H. (author)
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Geschwind, D. H. (author)
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Gill, M. (author)
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Hakonarson, H. (author)
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Hallmayer, J. (author)
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Palotie, A. (author)
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Santangelo, S. (author)
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Sutcliffe, J. S. (author)
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Arking, D. E. (author)
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i, Psych-Broad Autism Grp Psychiat Genomics Consortium (author)
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(creator_code:org_t)
- 2017-05-15
- 2017
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:7
- Related links:
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https://gup.ub.gu.se...
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Abstract
Subject headings
Close
- Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD cases, including those with strongly acting de novo variants, in which polygenic risk is relevant. Using a novel approach called the polygenic transmission disequilibrium test and data from 6,454 families with a child with ASD, we show that polygenic risk for ASD, schizophrenia, and greater educational attainment is over-transmitted to children with ASD. These findings hold independent of proband IQ. We find that polygenic variation contributes additively to risk in ASD cases who carry a strongly acting de novo variant. Lastly, we show that elements of polygenic risk are independent and differ in their relationship with phenotype. These results confirm that the genetic influences on ASD are additive and suggest that they create risk through at least partially distinct etiologic pathways.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- genome-wide association
- de-novo
- genetic risk
- general-population
- variants
- mutations
- insights
- disease
- biology
- loci
- Genetics & Heredity
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Weiner, D. J.
-
Wigdor, E. M.
-
Ripke, S.
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Walters, R. K.
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Kosmicki, J. A.
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Grove, J.
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show more...
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Samocha, K. E.
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Goldstein, J. I.
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Okbay, A.
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Bybjerg-Grauholm ...
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Werge, T.
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Hougaard, D. M.
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Taylor, J.
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Skuse, D.
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Devlin, B.
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Anney, R.
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Sanders, S. J.
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Bishop, S.
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Mortensen, P. B.
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Borglum, A. D.
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Smith, G. D.
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Daly, M. J.
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Robinson, E. B.
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Baekvad-Hansen, ...
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Dumont, A.
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Hansen, C.
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Hansen, T. F.
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Howrigan, D.
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Mattheisen, M.
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Moran, J.
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Mors, O.
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Nordentoft, M.
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Norgaard-Pederse ...
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Poterba, T.
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Poulsen, J.
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Stevens, C.
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Anttila, V.
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Holmans, P.
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Huang, H. L.
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Klei, L.
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Lee, P. H.
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Medland, S. E.
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Neale, B.
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Weiss, L. A.
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Zwaigenbaum, L.
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Yu, T. W.
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Wittemeyer, K.
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Willsey, A. J.
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Wijsman, E. M.
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Wassink, T. H.
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Waltes, R.
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Walsh, C. A.
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Wallace, S.
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Vorstman, J. A. ...
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Vieland, V. J.
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Vicente, A. M.
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van Engeland, H.
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Tsang, K.
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Thompson, A. P.
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Szatmari, P.
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Svantesson, O.
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Steinberg, S.
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Stefansson, K.
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Stefansson, H.
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State, M. W.
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Soorya, L.
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Silagadze, T.
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Scherer, S. W.
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Schellenberg, G. ...
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Sandin, S.
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Saemundsen, E.
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Rouleau, G. A.
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Roge, B.
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Roeder, K.
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Roberts, W.
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Reichert, J.
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Reichenberg, A.
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Rehnstrom, K.
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Regan, R.
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Poustka, F.
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Poultney, C. S.
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Piven, J.
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Pinto, D.
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Pericak-Vance, M ...
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Pejovic-Milovanc ...
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Pedersen, M. G.
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Pedersen, C. B.
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Paterson, A. D.
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Parr, J. R.
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Pagnamenta, A. T ...
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Oliveira, G.
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Nurnberger, J. I ...
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Murtha, M. T.
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Mouga, S.
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Morrow, E. M.
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De Luca, D. M.
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Monaco, A. P.
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Minshew, N.
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Merikangas, A.
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McMahon, W. M.
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McGrew, S. G.
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Martsenkovsky, I ...
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Martin, D. M.
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Mane, S. M.
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Magnusson, P.
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Magalhaes, T.
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Maestrini, E.
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Lowe, J. K.
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Lord, C.
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Levitt, P.
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Martin, C. L.
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Ledbetter, D. H.
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Leboyer, M.
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Le Couteur, A. S ...
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Ladd-Acosta, C.
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Kolevzon, A.
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Klauck, S. M.
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Jacob, S.
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Iliadou, B.
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Hultman, C. M.
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Hertz-Picciotto, ...
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Hendren, R.
-
Hansen, C. S.
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Haines, J. L.
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Guter, S. J.
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Grice, D. E.
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Green, J. M.
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Green, A.
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Goldberg, A. P.
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Gillberg, Christ ...
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Gilbert, J.
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Gallagher, L.
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Freitag, C. M.
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Fombonne, E.
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Folstein, S. E.
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Fernandez, B.
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Fallin, M. D.
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Ercan-Sencicek, ...
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Ennis, S.
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Duque, F.
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Duketis, E.
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Delorme, R.
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De Rubeis, S.
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De Jonge, M. V.
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Dawson, G.
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Cuccaro, M. L.
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Correia, C. T.
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Conroy, J.
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Conceicao, I. C.
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Chiocchetti, A. ...
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Celestino-Soper, ...
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Casey, J.
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Cantor, R. M.
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Cafe, C.
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Brennan, S.
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Bourgeron, T.
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Bolton, P. F.
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Bolte, S.
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Bolshakova, N.
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Betancur, C.
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Bernier, R.
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Beaudet, A. L.
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Battaglia, A.
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Bal, V. H.
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Baird, G.
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Bailey, A. J.
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Bader, J. S.
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Bacchelli, E.
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Anagnostou, E.
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Amaral, D.
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Almeida, J.
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Buxbaum, J. D.
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Chakravarti, A.
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Cook, E. H.
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Coon, H.
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Geschwind, D. H.
-
Gill, M.
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Hakonarson, H.
-
Hallmayer, J.
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Palotie, A.
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Santangelo, S.
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Sutcliffe, J. S.
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Arking, D. E.
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i, Psych-Broad A ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Nature Genetics
- By the university
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University of Gothenburg
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Karolinska Institutet