Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Roberts Christopher J.) > Polygenic transmiss...

Details
MARC

Weiner, D. J. (author)

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

Article/chapterEnglish2017

Publisher, publication year, extent ...

2017-05-15
Springer Science and Business Media LLC,2017

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/255452
https://gup.ub.gu.se/publication/255452URI
https://doi.org/10.1038/ng.3863DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:136091592URI

Supplementary language notes

Language:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD cases, including those with strongly acting de novo variants, in which polygenic risk is relevant. Using a novel approach called the polygenic transmission disequilibrium test and data from 6,454 families with a child with ASD, we show that polygenic risk for ASD, schizophrenia, and greater educational attainment is over-transmitted to children with ASD. These findings hold independent of proband IQ. We find that polygenic variation contributes additively to risk in ASD cases who carry a strongly acting de novo variant. Lastly, we show that elements of polygenic risk are independent and differ in their relationship with phenotype. These results confirm that the genetic influences on ASD are additive and suggest that they create risk through at least partially distinct etiologic pathways.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
genome-wide association
de-novo
genetic risk
general-population
variants
mutations
insights
disease
biology
loci
Genetics & Heredity

Added entries (persons, corporate bodies, meetings, titles ...)

Wigdor, E. M. (author)
Ripke, S. (author)
Walters, R. K. (author)
Kosmicki, J. A. (author)
Grove, J. (author)
Samocha, K. E. (author)
Goldstein, J. I. (author)
Okbay, A. (author)
Bybjerg-Grauholm, J. (author)
Werge, T. (author)
Hougaard, D. M. (author)
Taylor, J. (author)
Skuse, D. (author)
Devlin, B. (author)
Anney, R. (author)
Sanders, S. J.Karolinska Institutet (author)
Bishop, S. (author)
Mortensen, P. B. (author)
Borglum, A. D. (author)
Smith, G. D. (author)
Daly, M. J. (author)
Robinson, E. B. (author)
Baekvad-Hansen, M. (author)
Dumont, A. (author)
Hansen, C. (author)
Hansen, T. F. (author)
Howrigan, D. (author)
Mattheisen, M.Karolinska Institutet (author)
Moran, J. (author)
Mors, O. (author)
Nordentoft, M. (author)
Norgaard-Pedersen, B. (author)
Poterba, T. (author)
Poulsen, J. (author)
Stevens, C. (author)
Anttila, V. (author)
Holmans, P. (author)
Huang, H. L. (author)
Klei, L. (author)
Lee, P. H. (author)
Medland, S. E. (author)
Neale, B. (author)
Weiss, L. A. (author)
Zwaigenbaum, L. (author)
Yu, T. W. (author)
Wittemeyer, K. (author)
Willsey, A. J. (author)
Wijsman, E. M. (author)
Wassink, T. H. (author)
Waltes, R. (author)
Walsh, C. A. (author)
Wallace, S. (author)
Vorstman, J. A. S. (author)
Vieland, V. J. (author)
Vicente, A. M. (author)
van Engeland, H. (author)
Tsang, K. (author)
Thompson, A. P. (author)
Szatmari, P. (author)
Svantesson, O. (author)
Steinberg, S.Karolinska Institutet (author)
Stefansson, K. (author)
Stefansson, H. (author)
State, M. W. (author)
Soorya, L. (author)
Silagadze, T. (author)
Scherer, S. W. (author)
Schellenberg, G. D. (author)
Sandin, S. (author)
Saemundsen, E. (author)
Rouleau, G. A. (author)
Roge, B. (author)
Roeder, K. (author)
Roberts, W. (author)
Reichert, J. (author)
Reichenberg, A. (author)
Rehnstrom, K. (author)
Regan, R. (author)
Poustka, F. (author)
Poultney, C. S. (author)
Piven, J. (author)
Pinto, D. (author)
Pericak-Vance, M. A. (author)
Pejovic-Milovancevic, M. (author)
Pedersen, M. G. (author)
Pedersen, C. B. (author)
Paterson, A. D. (author)
Parr, J. R. (author)
Pagnamenta, A. T. (author)
Oliveira, G. (author)
Nurnberger, J. I. (author)
Nordentoft, M. (author)
Murtha, M. T. (author)
Mouga, S. (author)
Mors, O. (author)
Morrow, E. M. (author)
De Luca, D. M. (author)
Monaco, A. P. (author)
Minshew, N. (author)
Merikangas, A. (author)
McMahon, W. M. (author)
McGrew, S. G. (author)
Mattheisen, M. (author)
Martsenkovsky, I. (author)
Martin, D. M. (author)
Mane, S. M. (author)
Magnusson, P. (author)
Magalhaes, T. (author)
Maestrini, E. (author)
Lowe, J. K. (author)
Lord, C. (author)
Levitt, P. (author)
Martin, C. L. (author)
Ledbetter, D. H. (author)
Leboyer, M. (author)
Le Couteur, A. S. (author)
Ladd-Acosta, C. (author)
Kolevzon, A. (author)
Klauck, S. M. (author)
Jacob, S. (author)
Iliadou, B. (author)
Hultman, C. M. (author)
Hertz-Picciotto, I. (author)
Hendren, R. (author)
Hansen, C. S. (author)
Haines, J. L. (author)
Guter, S. J. (author)
Grice, D. E. (author)
Green, J. M. (author)
Green, A. (author)
Goldberg, A. P. (author)
Gillberg, Christopher,1950Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre(Swepub:gu)xgilch (author)
Gilbert, J. (author)
Gallagher, L. (author)
Freitag, C. M. (author)
Fombonne, E. (author)
Folstein, S. E. (author)
Fernandez, B. (author)
Fallin, M. D. (author)
Ercan-Sencicek, A. G. (author)
Ennis, S. (author)
Duque, F. (author)
Duketis, E. (author)
Delorme, R. (author)
De Rubeis, S. (author)
De Jonge, M. V. (author)
Dawson, G. (author)
Cuccaro, M. L. (author)
Correia, C. T. (author)
Conroy, J. (author)
Conceicao, I. C. (author)
Chiocchetti, A. G. (author)
Celestino-Soper, P. B. S. (author)
Casey, J. (author)
Cantor, R. M. (author)
Cafe, C. (author)
Brennan, S. (author)
Bourgeron, T. (author)
Bolton, P. F. (author)
Bolte, S. (author)
Bolshakova, N. (author)
Betancur, C. (author)
Bernier, R. (author)
Beaudet, A. L. (author)
Battaglia, A. (author)
Bal, V. H. (author)
Baird, G. (author)
Bailey, A. J. (author)
Baekvad-Hansen, M. (author)
Bader, J. S. (author)
Bacchelli, E. (author)
Anagnostou, E. (author)
Amaral, D. (author)
Almeida, J. (author)
Buxbaum, J. D. (author)
Chakravarti, A. (author)
Cook, E. H. (author)
Coon, H. (author)
Geschwind, D. H. (author)
Gill, M. (author)
Hakonarson, H. (author)
Hallmayer, J. (author)
Palotie, A. (author)
Santangelo, S. (author)
Sutcliffe, J. S. (author)
Arking, D. E. (author)
i, Psych-Broad Autism Grp Psychiat Genomics Consortium (author)
Karolinska InstitutetGillbergcentrum (creator_code:org_t)

Related titles

In:Nature Genetics: Springer Science and Business Media LLC49:71061-40361546-1718

Internet link

Find in a library

Nature Genetics (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Weiner, D. J.; Wigdor, E. M.; Ripke, S.; Walters, R. K.; Kosmicki, J. A.; Grove, J.; show more...; Samocha, K. E.; Goldstein, J. I.; Okbay, A.; Bybjerg-Grauholm ...; Werge, T.; Hougaard, D. M.; Taylor, J.; Skuse, D.; Devlin, B.; Anney, R.; Sanders, S. J.; Bishop, S.; Mortensen, P. B.; Borglum, A. D.; Smith, G. D.; Daly, M. J.; Robinson, E. B.; Baekvad-Hansen, ...; Dumont, A.; Hansen, C.; Hansen, T. F.; Howrigan, D.; Mattheisen, M.; Moran, J.; Mors, O.; Nordentoft, M.; Norgaard-Pederse ...; Poterba, T.; Poulsen, J.; Stevens, C.; Anttila, V.; Holmans, P.; Huang, H. L.; Klei, L.; Lee, P. H.; Medland, S. E.; Neale, B.; Weiss, L. A.; Zwaigenbaum, L.; Yu, T. W.; Wittemeyer, K.; Willsey, A. J.; Wijsman, E. M.; Wassink, T. H.; Waltes, R.; Walsh, C. A.; Wallace, S.; Vorstman, J. A. ...; Vieland, V. J.; Vicente, A. M.; van Engeland, H.; Tsang, K.; Thompson, A. P.; Szatmari, P.; Svantesson, O.; Steinberg, S.; Stefansson, K.; Stefansson, H.; State, M. W.; Soorya, L.; Silagadze, T.; Scherer, S. W.; Schellenberg, G. ...; Sandin, S.; Saemundsen, E.; Rouleau, G. A.; Roge, B.; Roeder, K.; Roberts, W.; Reichert, J.; Reichenberg, A.; Rehnstrom, K.; Regan, R.; Poustka, F.; Poultney, C. S.; Piven, J.; Pinto, D.; Pericak-Vance, M ...; Pejovic-Milovanc ...; Pedersen, M. G.; Pedersen, C. B.; Paterson, A. D.; Parr, J. R.; Pagnamenta, A. T ...; Oliveira, G.; Nurnberger, J. I ...; Murtha, M. T.; Mouga, S.; Morrow, E. M.; De Luca, D. M.; Monaco, A. P.; Minshew, N.; Merikangas, A.; McMahon, W. M.; McGrew, S. G.; Martsenkovsky, I ...; Martin, D. M.; Mane, S. M.; Magnusson, P.; Magalhaes, T.; Maestrini, E.; Lowe, J. K.; Lord, C.; Levitt, P.; Martin, C. L.; Ledbetter, D. H.; Leboyer, M.; Le Couteur, A. S ...; Ladd-Acosta, C.; Kolevzon, A.; Klauck, S. M.; Jacob, S.; Iliadou, B.; Hultman, C. M.; Hertz-Picciotto, ...; Hendren, R.; Hansen, C. S.; Haines, J. L.; Guter, S. J.; Grice, D. E.; Green, J. M.; Green, A.; Goldberg, A. P.; Gillberg, Christ ...; Gilbert, J.; Gallagher, L.; Freitag, C. M.; Fombonne, E.; Folstein, S. E.; Fernandez, B.; Fallin, M. D.; Ercan-Sencicek, ...; Ennis, S.; Duque, F.; Duketis, E.; Delorme, R.; De Rubeis, S.; De Jonge, M. V.; Dawson, G.; Cuccaro, M. L.; Correia, C. T.; Conroy, J.; Conceicao, I. C.; Chiocchetti, A. ...; Celestino-Soper, ...; Casey, J.; Cantor, R. M.; Cafe, C.; Brennan, S.; Bourgeron, T.; Bolton, P. F.; Bolte, S.; Bolshakova, N.; Betancur, C.; Bernier, R.; Beaudet, A. L.; Battaglia, A.; Bal, V. H.; Baird, G.; Bailey, A. J.; Bader, J. S.; Bacchelli, E.; Anagnostou, E.; Amaral, D.; Almeida, J.; Buxbaum, J. D.; Chakravarti, A.; Cook, E. H.; Coon, H.; Geschwind, D. H.; Gill, M.; Hakonarson, H.; Hallmayer, J.; Palotie, A.; Santangelo, S.; Sutcliffe, J. S.; Arking, D. E.; i, Psych-Broad A ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

Articles in the publication: Nature Genetics

By the university: University of Gothenburg; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se