The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children-Analyses based on path models.

The recent obesity epidemic in children also showed an increase in the prevalence of hypertension. As blood pressure (BP) is associated with (long-chain) polyunsaturated fatty acids (LC PUFA), genetic variation in desaturase enzymes being involved in the synthesis of LC PUFA may be associated with BP. This study aimed to investigate the direct effects (independent of mediating variables) and indirect effects (mediated through intermediate variables) of a common variant in the FADS1 gene, rs174546, known to affect delta-5 desaturase (D5D) activity on PUFA level, body mass index (BMI) and BP.A subsample of the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) baseline survey including 520 children aged 2 to <10 years from six European countries was included. The association between rs174546 (T

Dering, Carmen (author)
Siani, Alfonso (author)
Russo, Paola (author)
Kaprio, Jaakko (author)
Risé, Patrizia (author)
Moreno, Luis A (author)
De Henauw, Stefaan (author)
Mehlig, Kirsten,1964Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för folkhälsoepidemiologi,Institute of Medicine, Department of Public Health and Community Medicine, Public Health Epidemiology Unit(Swepub:gu)xmehki (author)
Veidebaum, Toomas (author)
Molnár, Denés (author)
Tornaritis, Michael (author)
Iacoviello, Licia (author)
Pitsiladis, Yannis (author)
Galli, Claudio (author)
Foraita, Ronja (author)
Börnhorst, Claudia (author)
Göteborgs universitetInstitutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för folkhälsoepidemiologi (creator_code:org_t)

By the author/editor: Wolters, Maike; Dering, Carmen; Siani, Alfonso; Russo, Paola; Kaprio, Jaakko; Risé, Patrizia; show more...; Moreno, Luis A; De Henauw, Stefa ...; Mehlig, Kirsten, ...; Veidebaum, Tooma ...; Molnár, Denés; Tornaritis, Mich ...; Iacoviello, Lici ...; Pitsiladis, Yann ...; Galli, Claudio; Foraita, Ronja; Börnhorst, Claud ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

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