SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Cerami C)
 

Search: WFRF:(Cerami C) > (2017) > Strategic roadmap f...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Frisoni, G. B.University of Geneva (author)

Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/255677
  • https://gup.ub.gu.se/publication/255677URI
  • https://doi.org/10.1016/S1474-4422(17)30159-XDOI
  • https://lup.lub.lu.se/record/145259c1-a2ac-476e-b62d-d030e8e18779URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:136182913URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The diagnosis of Alzheimer's disease can be improved by the use of biological measures. Biomarkers of functional impairment, neuronal loss, and protein deposition that can be assessed by neuroimaging (ie, MRI and PET) or CSF analysis are increasingly being used to diagnose Alzheimer's disease in research studies and specialist clinical settings. However, the validation of the clinical usefulness of these biomarkers is incomplete, and that is hampering reimbursement for these tests by health insurance providers, their widespread clinical implementation, and improvements in quality of health care. We have developed a strategic five-phase roadmap to foster the clinical validation of biomarkers in Alzheimer's disease, adapted from the approach for cancer biomarkers. Sufficient evidence of analytical validity (phase 1 of a structured framework adapted from oncology) is available for all biomarkers, but their clinical validity (phases 2 and 3) and clinical utility (phases 4 and 5) are incomplete. To complete these phases, research priorities include the standardisation of the readout of these assays and thresholds for normality, the evaluation of their performance in detecting early disease, the development of diagnostic algorithms comprising combinations of biomarkers, and the development of clinical guidelines for the use of biomarkers in qualified memory clinics.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Boccardi, M.Centro San Giovanni di Dio Fatebenefratelli,University of Geneva (author)
  • Barkhof, F.European Society of Neuroradiology,Amsterdam UMC - Vrije Universiteit Amsterdam,University College London (author)
  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Sahlgrenska University Hospital,Sahlgrenska Academy(Swepub:lu)med-kbw (author)
  • Cappa, S.Amsterdam UMC - Vrije Universiteit Amsterdam,Institute for Advanced Studies (IUSS), Pavia (author)
  • Chiotis, K.Karolinska Institutet,Karolinska Institute (author)
  • Demonet, J. F.Lausanne University Hospital (author)
  • Garibotto, V.University of Geneva (author)
  • Giannakopoulos, P.University of Geneva (author)
  • Gietl, A.University of Zurich (author)
  • Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-ohn (author)
  • Herholz, K.University of Manchester (author)
  • Jack, C. R.Mayo Clinic Minnesota,Vita-Salute San Raffaele University,San Raffaele Scientific Institute (author)
  • Nobili, F.Ospedale Policlinico San Martino,University of Genoa (author)
  • Nordberg, A.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital (author)
  • Snyder, H. M.Alzheimer's Association: Alzheimer's Disease and Dementia (author)
  • Ten Kate, M.Amsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Varrone, A.Karolinska Institutet,Stockholm County Council (author)
  • Albanese, E.University of Geneva (author)
  • Becker, S.Alzheimer's Switzerland (author)
  • Bossuyt, P.Academic Medical Center of University of Amsterdam (AMC) (author)
  • Carrillo, M. C.Alzheimer's Association: Alzheimer's Disease and Dementia (author)
  • Cerami, C. (author)
  • Dubois, B.Paris-Sorbonne University (author)
  • Gallo, V.Queen Mary University,Imperial College London (author)
  • Giacobini, E.University of Geneva (author)
  • Gold, G. (author)
  • Hurst, S.University of Geneva (author)
  • Lönneborg, AndersLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-ael (author)
  • Lovblad, K. O.Geneva University Hospital (author)
  • Mattsson, NiklasLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-nmn (author)
  • Molinuevo, J. L.Pasqual Maragall Foundation for Research on Alzheimer (author)
  • Monsch, A. U.Felix Platter Hospital (author)
  • Mosimann, U.University of Bern (author)
  • Padovani, A.University of Brescia (author)
  • Picco, A.University of Genoa,University of Geneva (author)
  • Porteri, C.Centro San Giovanni di Dio Fatebenefratelli (author)
  • Ratib, O.Geneva University Hospital (author)
  • Saint-Aubert, L.Karolinska Institute (author)
  • Scerri, C.Alzheimer Europe,University of Malta (author)
  • Scheltens, P.Amsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Schott, J. M.University College London (author)
  • Sonni, I.Stockholm County Council,Stanford University (author)
  • Teipel, S.University of Rostock,German Center for Neurodegenerative Diseases (DZNE), Bonn (author)
  • Vineis, P. (author)
  • Visser, P. J.Maastricht University,Amsterdam UMC - Vrije Universiteit Amsterdam (author)
  • Yasui, Y.St Jude Children´s Research Hospital, Memphis (author)
  • Winblad, B.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,European Alzheimer's Disease Consortium (EADC) (author)
  • University of GenevaCentro San Giovanni di Dio Fatebenefratelli (creator_code:org_t)

Related titles

  • In:Lancet Neurology16:8, s. 661-6761474-44221474-4465

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view