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Strategic roadmap f...
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Frisoni, G. B.University of Geneva
(author)
Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers
- Article/chapterEnglish2017
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/255677
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https://gup.ub.gu.se/publication/255677URI
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https://doi.org/10.1016/S1474-4422(17)30159-XDOI
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https://lup.lub.lu.se/record/145259c1-a2ac-476e-b62d-d030e8e18779URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:136182913URI
Supplementary language notes
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The diagnosis of Alzheimer's disease can be improved by the use of biological measures. Biomarkers of functional impairment, neuronal loss, and protein deposition that can be assessed by neuroimaging (ie, MRI and PET) or CSF analysis are increasingly being used to diagnose Alzheimer's disease in research studies and specialist clinical settings. However, the validation of the clinical usefulness of these biomarkers is incomplete, and that is hampering reimbursement for these tests by health insurance providers, their widespread clinical implementation, and improvements in quality of health care. We have developed a strategic five-phase roadmap to foster the clinical validation of biomarkers in Alzheimer's disease, adapted from the approach for cancer biomarkers. Sufficient evidence of analytical validity (phase 1 of a structured framework adapted from oncology) is available for all biomarkers, but their clinical validity (phases 2 and 3) and clinical utility (phases 4 and 5) are incomplete. To complete these phases, research priorities include the standardisation of the readout of these assays and thresholds for normality, the evaluation of their performance in detecting early disease, the development of diagnostic algorithms comprising combinations of biomarkers, and the development of clinical guidelines for the use of biomarkers in qualified memory clinics.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Boccardi, M.Centro San Giovanni di Dio Fatebenefratelli,University of Geneva
(author)
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Barkhof, F.European Society of Neuroradiology,Amsterdam UMC - Vrije Universiteit Amsterdam,University College London
(author)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Sahlgrenska University Hospital,Sahlgrenska Academy(Swepub:lu)med-kbw
(author)
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Cappa, S.Amsterdam UMC - Vrije Universiteit Amsterdam,Institute for Advanced Studies (IUSS), Pavia
(author)
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Chiotis, K.Karolinska Institutet,Karolinska Institute
(author)
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Demonet, J. F.Lausanne University Hospital
(author)
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Garibotto, V.University of Geneva
(author)
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Giannakopoulos, P.University of Geneva
(author)
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Gietl, A.University of Zurich
(author)
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Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-ohn
(author)
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Herholz, K.University of Manchester
(author)
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Jack, C. R.Mayo Clinic Minnesota,Vita-Salute San Raffaele University,San Raffaele Scientific Institute
(author)
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Nobili, F.Ospedale Policlinico San Martino,University of Genoa
(author)
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Nordberg, A.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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Snyder, H. M.Alzheimer's Association: Alzheimer's Disease and Dementia
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Ten Kate, M.Amsterdam UMC - Vrije Universiteit Amsterdam
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Varrone, A.Karolinska Institutet,Stockholm County Council
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Albanese, E.University of Geneva
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Becker, S.Alzheimer's Switzerland
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Bossuyt, P.Academic Medical Center of University of Amsterdam (AMC)
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Carrillo, M. C.Alzheimer's Association: Alzheimer's Disease and Dementia
(author)
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Cerami, C.
(author)
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Dubois, B.Paris-Sorbonne University
(author)
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Gallo, V.Queen Mary University,Imperial College London
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Giacobini, E.University of Geneva
(author)
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Gold, G.
(author)
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Hurst, S.University of Geneva
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Lönneborg, AndersLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-ael
(author)
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Lovblad, K. O.Geneva University Hospital
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Mattsson, NiklasLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-nmn
(author)
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Molinuevo, J. L.Pasqual Maragall Foundation for Research on Alzheimer
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Monsch, A. U.Felix Platter Hospital
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Mosimann, U.University of Bern
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Padovani, A.University of Brescia
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Picco, A.University of Genoa,University of Geneva
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Porteri, C.Centro San Giovanni di Dio Fatebenefratelli
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Ratib, O.Geneva University Hospital
(author)
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Saint-Aubert, L.Karolinska Institute
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Scerri, C.Alzheimer Europe,University of Malta
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Scheltens, P.Amsterdam UMC - Vrije Universiteit Amsterdam
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Schott, J. M.University College London
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Sonni, I.Stockholm County Council,Stanford University
(author)
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Teipel, S.University of Rostock,German Center for Neurodegenerative Diseases (DZNE), Bonn
(author)
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Vineis, P.
(author)
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Visser, P. J.Maastricht University,Amsterdam UMC - Vrije Universiteit Amsterdam
(author)
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Yasui, Y.St Jude Children´s Research Hospital, Memphis
(author)
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Winblad, B.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,European Alzheimer's Disease Consortium (EADC)
(author)
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University of GenevaCentro San Giovanni di Dio Fatebenefratelli
(creator_code:org_t)
Related titles
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In:Lancet Neurology16:8, s. 661-6761474-44221474-4465
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Find in a library
To the university's database
- By the author/editor
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Frisoni, G. B.
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Boccardi, M.
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Barkhof, F.
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Blennow, Kaj, 19 ...
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Cappa, S.
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Chiotis, K.
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show more...
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Demonet, J. F.
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Garibotto, V.
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Giannakopoulos, ...
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Gietl, A.
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Hansson, Oskar
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Herholz, K.
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Jack, C. R.
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Nobili, F.
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Nordberg, A.
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Snyder, H. M.
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Ten Kate, M.
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Varrone, A.
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Albanese, E.
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Becker, S.
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Bossuyt, P.
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Carrillo, M. C.
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Cerami, C.
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Dubois, B.
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Gallo, V.
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Giacobini, E.
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Gold, G.
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Hurst, S.
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Lönneborg, Ander ...
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Lovblad, K. O.
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Mattsson, Niklas
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Molinuevo, J. L.
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Monsch, A. U.
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Mosimann, U.
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Padovani, A.
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Picco, A.
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Porteri, C.
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Ratib, O.
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Saint-Aubert, L.
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Scerri, C.
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Scheltens, P.
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Schott, J. M.
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Sonni, I.
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Teipel, S.
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Vineis, P.
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Visser, P. J.
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Yasui, Y.
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Winblad, B.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Lancet Neurology
- By the university
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University of Gothenburg
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Lund University
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Karolinska Institutet