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Mycophenolate mofet...
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Jonsson, Charlotte A,1971Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
(author)
Mycophenolate mofetil ameliorates perivascular T lymphocyte inflammation and reduces the double-negative T cell population in SLE-prone MRLlpr/lpr mice.
- Article/chapterEnglish1999
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/256425
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https://gup.ub.gu.se/publication/256425URI
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https://doi.org/10.1006/cimm.1999.1570DOI
Supplementary language notes
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Effects on T lymphocyte mediated pathology, phenotypes, and functions in MRLlpr/lpr mice given mycophenolate mofetil (MMF) (100 mg/kg/day) via drinking water or controls given ip cyclophosphamide (CYC) injections (1.8 mg/mouse/week) or water were described. Both MMF and CYC treatment diminished kidney and large salivary gland perivascular cell infiltrates, reduced profoundly double-negative (DN) T cell frequencies, decreased total lymphocyte number in spleen, and increased in vitro proliferative response to Con A. IFN-gamma and IL-10 in supernatants from Con A stimulated spleen cells were augmented after MMF but not CYC treatment. MMF treatment increased whereas CYC reduced IL-12 in serum. Kidney expressions of IFN-gamma, IL-10, and IL-12 mRNA were unaffected by MMF but decreased by CYC. Our results demonstrate that MMF and CYC suppress perivascular T lymphocyte inflammation by reducing the DN T cell population and by amelioration of T cell function. The varying cytokine patterns suggest different mechanisms of the two drugs.
Subject headings and genre
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MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
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MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
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Animals
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Anti-Inflammatory Agents
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Non-Steroidal
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pharmacology
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B-Lymphocytes
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drug effects
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immunology
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Cell Count
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Cell Division
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Concanavalin A
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pharmacology
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Cyclophosphamide
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pharmacology
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Cytokines
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blood
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genetics
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Disease Models
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Animal
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Female
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Hypersensitivity
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Delayed
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Immunophenotyping
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Immunosuppressive Agents
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pharmacology
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Kidney
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blood supply
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cytology
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immunology
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Lupus Erythematosus
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Systemic
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immunology
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Male
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Mice
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Mice
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Inbred MRL lpr
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Mycophenolic Acid
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analogs & derivatives
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pharmacology
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RNA
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Messenger
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Salivary Glands
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blood supply
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cytology
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Spleen
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cytology
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immunology
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T-Lymphocytes
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cytology
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drug effects
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immunology
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Vasculitis
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pathology
Added entries (persons, corporate bodies, meetings, titles ...)
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Erlandsson, Malin,1972Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research(Swepub:gu)xerlma
(author)
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Svensson, Lena,1958Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
(author)
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Mölne, J
(author)
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Carlsten, Hans,1954Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research(Swepub:gu)xcahan
(author)
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Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning
(creator_code:org_t)
Related titles
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In:Cellular immunology: Elsevier BV197:2, s. 136-440008-8749
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