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Long-term effects o...
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Kristensson, Felipe M.Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
(författare)
Long-term effects of bariatric surgery in patients with obesity and chromosome 16 p11.2 microdeletion
- Artikel/kapitelEngelska2017
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LIBRIS-ID:oai:gup.ub.gu.se/257802
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https://gup.ub.gu.se/publication/257802URI
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https://doi.org/10.1016/j.soard.2017.04.024DOI
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Background: Chromosome 16 p11.2 microdeletion is associated with early-onset obesity. Information is limited about the effect of bariatric surgery in patients with genetic obesity. Objective: To examine the effects of bariatric surgery in obese patients with chromosome 16 p11.2 microdeletion. Methods: The Swedish Obese Subjects study is a prospective study with 2010 participants receiving bariatric surgery. DNA was available for 1843 participants. Multiplex ligation-dependent probe amplification was used to identify 16 p11.2 microdeletion carriers. Follow-up time was 10 years. In carriers and noncarriers, follow-up rate was 86% and 82%, respectively, at 10 years. Results: Nine carriers of the chromosome 16 p11.2 microdeletion (9/1843, .49%) were found. At baseline, most risk factors were similar; however, carriers had higher body mass index (BMI), insulin levels, and systolic blood pressure compared to noncarriers. At the 1 -year examination, the percent excess BMI lost (%EBMIL) in carriers and noncarriers was 71.9 and 62.2, respectively; P = .031 (37.9 and 30.6 kg). This was followed by partial weight regain in both groups, and after 10 years %BBMIL was 25.5 and 41.5 (15.7 and 21.3 kg), respectively (P = .377). Changes in risk factors were similar in the carriers and noncarriers. Two carriers who had type 2 diabetes at baseline were both in remission at 2 -year follow-up but relapsed at 10 -year follow-up. Perceived health status was similar in carriers and noncarriers during follow-up (overall P = .198). Conclusions: Despite a small sample size, our results indicate that bariatric surgery is a treatment option for obese patients with chromosome 16 p11.2 microdeletion. (Surg Obes Relat Dis 2017;13:1321-1326.) (C) 2017 American Society for Metabolic and Bariatric Surgery. All rights reserved.
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Andersson-Assarsson, Johanna C.,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xanjoh
(författare)
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Kanerva, NooraGothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
(författare)
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Peltonen, M.
(författare)
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Carlsson, Björn,1958Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xcarbj
(författare)
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Carlsson, Lena M S,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xcarle
(författare)
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Göteborgs universitetInstitutionen för medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Surgery for Obesity and Related Diseases: Elsevier BV13:8, s. 1321-13261550-7289
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