Search: onr:"swepub:oai:gup.ub.gu.se/258836" >
Acquired Immune Res...
Acquired Immune Resistance Follows Complete Tumor Regression without Loss of Target Antigens or IFN gamma Signaling
- Article/chapterEnglish2017
Publisher, publication year, extent ...
-
2017-08-31
-
American Association for Cancer Research (AACR),2017
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/258836
-
https://gup.ub.gu.se/publication/258836URI
-
https://doi.org/10.1158/0008-5472.can-16-3172DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Cancer immunotherapy can result in durable tumor regressions in some patients. However, patients who initially respond often experience tumor progression. Here, we report mechanistic evidence of tumoral immune escape in an exemplary clinical case: a patient with metastatic melanoma who developed disease recurrence following an initial, unequivocal radiologic complete regression after T-cell-based immunotherapy. Functional cytotoxic T-cell responses, including responses to one mutant neoantigen, were amplified effectively with therapy and generated durable immunologic memory. However, these immune responses, including apparently effective surveillance of the tumor mutanome, did not prevent recurrence. Alterations of the MHC class I antigen-processing and presentation machinery (APM) in resistant cancer cells, but not antigen loss or impaired IFN gamma signaling, led to impaired recognition by tumor-specific CD8(+) T cells. Our results suggest that future immunotherapy combinations should take into account targeting cancer cells with intact and impaired MHC class I-related APM. Loss of target antigens or impaired IFN gamma signaling does not appear to be mandatory for tumor relapse after a complete radiologic regression. Personalized studies to uncover mechanisms leading to disease recurrence within each individual patient are warranted.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Harbst, K.
(author)
-
van Buuren, M.
(author)
-
Kvistborg, P.
(author)
-
Lindberg, Mattias FGothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
(author)
-
Andersen, R.
(author)
-
Idorn, M.
(author)
-
Ahmad, S. M.
(author)
-
Ellebaek, E.
(author)
-
Mueller, A.
(author)
-
Fagone, P.
(author)
-
Nicoletti, F.
(author)
-
Libra, M.
(author)
-
Lauss, M.
(author)
-
Hadrup, S. R.
(author)
-
Schmidt, H.
(author)
-
Andersen, M. H.
(author)
-
Straten, P. T.
(author)
-
Nilsson, J. A.
(author)
-
Schumacher, TonGothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
(author)
-
Seliger, B.
(author)
-
Jonsson, G.
(author)
-
Svane, I. M.
(author)
-
Göteborgs universitetSahlgrenska Cancer Center
(creator_code:org_t)
Related titles
-
In:Cancer Research: American Association for Cancer Research (AACR)77:17, s. 4562-45660008-54721538-7445
Internet link
Find in a library
To the university's database
- By the author/editor
-
Donia, M.
-
Harbst, K.
-
van Buuren, M.
-
Kvistborg, P.
-
Lindberg, Mattia ...
-
Andersen, R.
-
show more...
-
Idorn, M.
-
Ahmad, S. M.
-
Ellebaek, E.
-
Mueller, A.
-
Fagone, P.
-
Nicoletti, F.
-
Libra, M.
-
Lauss, M.
-
Hadrup, S. R.
-
Schmidt, H.
-
Andersen, M. H.
-
Straten, P. T.
-
Nilsson, J. A.
-
Schumacher, Ton
-
Seliger, B.
-
Jonsson, G.
-
Svane, I. M.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Cancer Research
- By the university
-
University of Gothenburg