Antiplatelet Therapy, Platelet Function Testing, and Bleeding Complications in Cardiac Surgery Patients

• Antiplatelet therapy with acetylsalicylic acid, alone or in combination with a P2Y(12) inhibitor, reduces thromboembolic events in patients with coronary artery disease but increases the risk for spontaneous and perioperative bleeding complications. Both the antiplatelet effect and the risk for bleeding complications are larger with the new generation P2Y(12) inhibitors prasugrel and ticagrelor than with clopidogrel. In this review, the perioperative handling of acetylsalicylic acid and the P2Y(12) inhibitors clopidogrel, prasugrel, and ticagrelor will be discussed. In addition, the concept of platelet function testing in the surgical setting will be covered.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Keyword

antiplatelet therapy

acetylsalicylic acid

P2Y(12) inhibitors

bleeding

coronary artery bypass grafting

acute coronary syndromes

acute myocardial-infarction

artery-bypass

surgery

st-segment elevation

blood-transfusion

unstable angina

clopidogrel

ticagrelor

aspirin

trial

Hematology

Cardiovascular System & Cardiology

Publication and Content Type

ref (subject category)

art (subject category)