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Defining the geneti...
Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study
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- Leo, P. J. (author)
- Queensland University of Technology
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- Madeleine, M. M. (author)
- Fred Hutchinson Cancer Research Center,Queensland University of Technology,The Royal Women's Hospital,University of Melbourne
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- Wang, S. (author)
- City of Hope National Medical Center
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- Schwartz, S. M. (author)
- National Cancer Institute, USA
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- Newell, F. (author)
- Queensland University of Technology
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- Pettersson-Kymmer, Ulrika (author)
- Umeå University,Umeå universitet,Farmakologi,Näringsforskning
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- Hemminki, Kari (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre
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- Hallmans, Göran (author)
- Umeå University,Umeå universitet,Näringsforskning
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- Tiews, S. (author)
- Dr.Steinberg GmbH
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- Steinberg, W. (author)
- Dr.Steinberg GmbH
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- Rader, J. S. (author)
- Medical College of Wisconsin
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- Castro, F. (author)
- German Cancer Research Centre
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Safaeian, M. (author)
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- Franco, E. L. (author)
- McGill University
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- Coutlee, F. (author)
- University Of Quebec In Montreal
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska Academy
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- Cortes, A. (author)
- Queensland University of Technology
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Marshall, M. (author)
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- Mukhopadhyay, P. (author)
- Queensland University of Technology
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- Cremin, K. (author)
- Queensland University of Technology
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- Johnson, L. G. (author)
- Fred Hutchinson Cancer Research Center
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Garland, S. (author)
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- Tabrizi, S. N. (author)
- University of Melbourne
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- Wentzensen, N. (author)
- National Cancer Institute, USA
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- Sitas, F. (author)
- University of Sydney,University of New South Wales,Cancer Council New South Wales
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- Little, J. (author)
- University of Ottawa
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- Cruickshank, M. (author)
- University of Aberdeen
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- Frazer, I. H. (author)
- University of Queensland
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- Hildesheim, A. (author)
- National Cancer Institute, USA
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- Brown, M. A. (author)
- Queensland University of Technology
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(creator_code:org_t)
- 2017-08-14
- 2017
- English.
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In: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 13:8
- Related links:
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https://journals.plo...
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https://umu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- A small percentage of women with cervical HPV infection progress to cervical neoplasia, and the risk factors determining progression are incompletely understood. We sought to define the genetic loci involved in cervical neoplasia and to assess its heritability using unbiased unrelated case/control statistical approaches. We demonstrated strong association of cervical neoplasia with risk and protective HLA haplotypes that are determined by the amino-acids carried at positions 13 and 71 in pocket 4 of HLA-DRB1 and position 156 in HLA-B. Furthermore, 36% (standard error 2.4%) of liability of HPV-associated cervical pre-cancer and cancer is determined by common genetic variants. Women in the highest 10% of genetic risk scores have approximately > 7.1% risk, and those in the highest 5% have approximately > 21.6% risk, of developing cervical neoplasia. Future studies should examine genetic risk prediction in assessing the risk of cervical neoplasia further, in combination with other screening methods.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- human-papillomavirus infection
- squamous-cell carcinoma
- comprehensive
- analysis
- familial risks
- complex traits
- united-states
- hla-b
- cancer
- women
- loci
- Genetics & Heredity
- cervical neoplasia
- molekylär medicin (genetik och patologi)
- Cancer Epidemiology
- GWAS
- cervical neoplasia
- genetic susceptibility
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Leo, P. J.
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Madeleine, M. M.
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Wang, S.
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Schwartz, S. M.
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Newell, F.
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Pettersson-Kymme ...
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show more...
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Hemminki, Kari
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Hallmans, Göran
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Tiews, S.
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Steinberg, W.
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Rader, J. S.
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Castro, F.
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Safaeian, M.
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Franco, E. L.
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Coutlee, F.
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Ohlsson, Claes, ...
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Cortes, A.
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Marshall, M.
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Mukhopadhyay, P.
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Cremin, K.
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Johnson, L. G.
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Garland, S.
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Tabrizi, S. N.
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Wentzensen, N.
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Sitas, F.
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Little, J.
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Cruickshank, M.
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Frazer, I. H.
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Hildesheim, A.
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Brown, M. A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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PLoS Genetics
- By the university
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University of Gothenburg
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Umeå University
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Lund University