Ondansetron treatment reduces rotavirus symptoms-A randomized double-blinded placebo-controlled trial

Hagbom, MarieLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten (author)

Funding Agencies|Swedish Research Council [320301]; Swedish Research Council
Background Rotavirus and norovirus cause acute gastroenteritis with severe diarrhoea and vomiting, symptoms that may lead to severe dehydration and death. The objective of this randomized double-blinded placebo-controlled study was to investigate whether ondansetron, a serotonin receptor antagonist could attenuate rotavirus-and norovirus-induced vomiting and diarrhoea, which would facilitate oral rehydration and possibly accelerate recovery and reduce need for hospitalization. Children with acute gastroenteritis, aged 6 months to 16 years where enrolled (n = 104) and randomized to one single oral dose (0.15mg/kg) of ondansetron (n = 52) or placebo (n = 52). The number of diarrhoea and vomiting episodes during the 24 hours following treatment was reported as well as the number of days with symptoms. Pathogens in faeces were diagnosed by real-time PCR. Outcome parameters were analyzed for rotavirus-and noroviruspositive children. One dose of oral ondansetron reduced duration of rotavirus clinical symptoms (p = 0.014), with a median of two days. Furthermore, ondansetron reduced diarrhea episodes, most pronounced in children that had been sick for more than 3 days before treatment (p = 0.028). Ondansetron may be a beneficial treatment for children with rotavirus gastroenteritis.

Novak, D.Sahlgrens University Hospital, Sweden (author)
Ekstrom, M.Sahlgrens University Hospital, Sweden (author)
Khalid, Y.Sahlgrens University Hospital, Sweden (author)
Andersson, MariaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg, Sweden(Swepub:gu)xanman (author)
Lindh, Magnus,1960Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg, Sweden(Swepub:gu)xlmagr (author)
Nordgren, JohanLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten(Swepub:liu)johno12 (author)
Svensson, LennartKarolinska Institutet,Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Karolinska Institute, Sweden(Swepub:liu)lensv66 (author)
Linköpings universitetAvdelningen för mikrobiologi och molekylär medicin (creator_code:org_t)

By the author/editor: Hagbom, Marie; Novak, D.; Ekstrom, M.; Khalid, Y.; Andersson, Maria; Lindh, Magnus, 1 ...; show more...; Nordgren, Johan; Svensson, Lennar ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Infectious Medic ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

By the university: University of Gothenburg; Linköping University; Karolinska Institutet

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