Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies

• Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract with a multifactorial pathophysiology. Full comprehension of IBD pathology is still out of reach and, therefore, treatment is far from ideal. Nevertheless, components involved in IBD pathogenesis including environmental, genetic, microbial, and immunological factors are continuously being investigated and the improved knowledge contributes to the development of new therapies. In this article we review the aspects of the immunopathogenesis of IBD, with focus on mucosal immunity, and discuss mechanisms of action for current and emerging biological therapies.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

Nyckelord

IBD

immunopathogenesis

Crohn's disease

ulcerative colitis

chronic inflammation

dysregulated

innate lymphoid-cells

severe crohns-disease

placebo-controlled trial

regulatory t-cell

intestinal epithelial-cells

toll-like receptor-9

anti-tnf therapy

ulcerative-colitis

dendritic cells

maintenance

therapy

Gastroenterology & Hepatology .

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)