Long-term outcome after right ventricle to pulmonary artery conduit surgery and reintervention.

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Skoglund, Kristofer,1976Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska University Hospital (författare)

Long-term outcome after right ventricle to pulmonary artery conduit surgery and reintervention.

Artikel/kapitelEngelska2017

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2017-06-23
Informa UK Limited,2017

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LIBRIS-ID:oai:gup.ub.gu.se/260046
https://gup.ub.gu.se/publication/260046URI
https://doi.org/10.1080/14017431.2017.1343492DOI
https://lup.lub.lu.se/record/524fef0f-3518-46a2-adc6-c873b840427cURI

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Språk:engelska

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Ämneskategori:art swepub-publicationtype

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Reconstruction of the right ventricular outflow tract with a conduit is an established surgical procedure in congenital heart disease and reinterventions are common.An increasing number of patients have a conduit, but there are few population-based studies of long-term outcomes after conduit surgery, reoperations, and transcatheter pulmonary valve replacement.In April 2015, all adult patients with a conduit were identified in the Swedish National Registry for Congenital Heart Disease (SWEDCON). Data on patients who died before age of 16 years are not included in the registry and thus not included in the study.We found 574 patients with a mean age 36.1 years. The largest proportion had tetralogy of Fallot (45%). In total there were 762 operations and 50 transcatheter pulmonary valve replacements. Mean age at first conduit operation was 20.2 years. Long-term survival up to 48 years including perioperative mortality (<1%) was 93% at 20 years. The most common cause of death was cardiac-related. Higher age at first conduit operation was associated with increased mortality risk. Reintervention-free survival was 77% and 54% at 10 and 20 years, respectively. Conduit reinterventions were common. Ten-year reintervention-free survival after first conduit reintervention (n=176) was significantly lower than after first conduit operation (70% vs 77% p=.04). Higher age at first conduit operation was associated with a reduced risk of reintervention, whereas male sex and complex malformations were associated with increased risk of reintervention.The mortality of repeated conduit reinterventions is low. The need for reintervention of conduits is considerable, and reintervention-free survival after the first conduit reintervention is poorer than after first conduit implantation. The findings in this study only applies for patients reaching 16 years of age.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Adolescent
Adult
Aged
Blood Vessel Prosthesis Implantation
adverse effects
mortality
Disease-Free Survival
Female
Heart Defects
Congenital
diagnosis
mortality
physiopathology
surgery
Heart Valve Prosthesis Implantation
adverse effects
mortality
Heart Ventricles
physiopathology
surgery
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Postoperative Complications
surgery
Proportional Hazards Models
Pulmonary Artery
physiopathology
surgery
Registries
Reoperation
Retrospective Studies
Risk Factors
Sweden
Time Factors
Treatment Outcome
Young Adult
conduit
Congenital heart disease
reintervention
transcatheter pulmonary valve replacement

Biuppslag (personer, institutioner, konferenser, titlar ...)

Svensson, Gunnar,1951Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska University Hospital(Swepub:gu)xsvgun (författare)
Thilén, UlfLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)kard-uth (författare)
Dellborg, Mikael,1954Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska University Hospital(Swepub:gu)xdelmi (författare)
Eriksson, Peter J,1959Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska University Hospital(Swepub:gu)xerpet (författare)
Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)

Sammanhörande titlar

Ingår i:Scandinavian cardiovascular journal : SCJ: Informa UK Limited51:5, s. 284-2911651-20061401-7431

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Av författaren/redakt...: Skoglund, Kristo ...; Svensson, Gunnar ...; Thilén, Ulf; Dellborg, Mikael ...; Eriksson, Peter ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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Av lärosätet: Göteborgs universitet; Lunds universitet

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