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Association of Cere...
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Jansen, Willemijn JDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands
(author)
Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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American Medical Association (AMA),2018
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/260496
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https://gup.ub.gu.se/publication/260496URI
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https://doi.org/10.1001/jamapsychiatry.2017.3391DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-79268URI
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https://lup.lub.lu.se/record/3ab52246-eebe-4f88-8211-9fe063a468a8URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:137400512URI
Supplementary language notes
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies:United States Department of Health & Human Services National Institutes of Health (NIH) - USA, NIH National Center for Research Resources (NCRR), Appeared in article as NCRR NIH HHS, Grant number: C06 RR018898United States Department of Health & Human Services National Institutes of Health (NIH) - USA, NIH National Institute on Aging (NIA), Appeared in article as NIA NIH HHS, Grant numbers: R01 AG045611, RF1 AG025516, P50 AG005133, P01 AG026276, P50 AG005681, P01 AG003991, P30 AG010124, P50 AG023501, P01 AG025204
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Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the course of AD and for the design of prevention trials.To investigate whether amyloid-β aggregation is associated with cognitive functioning in persons without dementia.This cross-sectional study included 2908 participants with normal cognition and 4133 with mild cognitive impairment (MCI) from 53 studies in the multicenter Amyloid Biomarker Study. Normal cognition was defined as having no cognitive concerns for which medical help was sought and scores within the normal range on cognitive tests. Mild cognitive impairment was diagnosed according to published criteria. Study inclusion began in 2013 and is ongoing. Data analysis was performed in January 2017.Global cognitive performance as assessed by the Mini-Mental State Examination (MMSE) and episodic memory performance as assessed by a verbal word learning test. Amyloid aggregation was measured with positron emission tomography or cerebrospinal fluid biomarkers and dichotomized as negative (normal) or positive (abnormal) according to study-specific cutoffs. Generalized estimating equations were used to examine the association between amyloid aggregation and low cognitive scores (MMSE score ≤27 or memory z score≤-1.28) and to assess whether this association was moderated by age, sex, educational level, or apolipoprotein E genotype.Among 2908 persons with normal cognition (mean [SD] age, 67.4 [12.8] years), amyloid positivity was associated with low memory scores after age 70 years (mean difference in amyloid positive vs negative, 4% [95% CI, 0%-7%] at 72 years and 21% [95% CI, 10%-33%] at 90 years) but was not associated with low MMSE scores (mean difference, 3% [95% CI, -1% to 6%], P=.16). Among 4133 patients with MCI (mean [SD] age, 70.2 [8.5] years), amyloid positivity was associated with low memory (mean difference, 16% [95% CI, 12%-20%], P<.001) and low MMSE (mean difference, 14% [95% CI, 12%-17%], P<.001) scores, and this association decreased with age. Low cognitive scores had limited utility for screening of amyloid positivity in persons with normal cognition and those with MCI. In persons with normal cognition, the age-related increase in low memory score paralleled the age-related increase in amyloid positivity with an intervening period of 10 to 15 years.Although low memory scores are an early marker of amyloid positivity, their value as a screening measure for early AD among persons without dementia is limited.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Ossenkoppele, RikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam(Swepub:lu)ri1513os
(author)
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Tijms, Betty MAmsterdam UMC - Vrije Universiteit Amsterdam
(author)
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Fagan, Anne MWashington University in St. Louis
(author)
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Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-ohn
(author)
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Klunk, William EUniversity of Pittsburgh
(author)
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van der Flier, Wiesje MAmsterdam UMC - Vrije Universiteit Amsterdam
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Villemagne, Victor LAustin Health
(author)
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Frisoni, Giovanni BCentro San Giovanni di Dio Fatebenefratelli
(author)
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Fleisher, Adam SEli Lilly and Company,University of California, San Diego
(author)
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Lleó, AlbertoHospital de Sant Pau
(author)
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Mintun, Mark AAvid Radiopharmaceuticals, Inc
(author)
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Wallin, Anders,1950Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska Academy(Swepub:gu)xwaand
(author)
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Engelborghs, SebastiaanUniversity of Antwerp
(author)
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Na, Duk LSungkyunkwan University
(author)
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Chételat, GäelCentre Hospitalier Privé Saint-Martin
(author)
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Molinuevo, José LuisInstitutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)
(author)
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Landau, Susan MUniversity of California, Berkeley
(author)
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Mattsson, NiklasLund University,Lunds universitet,Brain Injury After Cardiac Arrest,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)med-nmn
(author)
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Kornhuber, JohannesFriedrich-Alexander University Erlangen-Nürnberg
(author)
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Sabri, OsamaLeipzig University
(author)
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Rowe, Christopher CAustin Health,Washington University in St. Louis
(author)
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Parnetti, LucillaUniversity of Perugia
(author)
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Popp, JuliusLausanne University Hospital
(author)
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Fladby, TormodAkershus University Hospital
(author)
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Jagust, William JUniversity of California, Berkeley
(author)
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Aalten, PaulineMaastricht University
(author)
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Lee, Dong YoungSeoul National University
(author)
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Vandenberghe, RikCatholic University of Leuven
(author)
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Resende de Oliveira, CatarinaUniversity Hospital of Coimbra
(author)
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Kapaki, ElisabethEginition Hospital
(author)
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Froelich, LutzHeidelberg University
(author)
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Ivanoiu, AdrianSaint-Luc University Hospital
(author)
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Gabryelewicz, TomaszInstitute - Center for Molecular and Macromolecular Studies of the Polish Academy of Sciences
(author)
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Verbeek, Marcel MRadboud University Nijmegen
(author)
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Sanchez-Juan, PáscualUniversity of Cantabria
(author)
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Hildebrandt, HelmutHospital of Bremen-Ost
(author)
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Camus, VincentUniversity Of Tours
(author)
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Zboch, MarzenaWrocław Medical University
(author)
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Brooks, David JImperial College London
(author)
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Drzezga, AlexanderUniversity of Cologne
(author)
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Rinne, Juha OTurku PET Centre
(author)
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Newberg, AndrewThomas Jefferson University
(author)
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de Mendonça, AlexandreUniversity of Lisbon
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Sarazin, MarieParis Descartes University
(author)
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Rabinovici, Gil DUniversity of Texas Health Science Centre
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Madsen, Karine
(author)
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Kramberger, Milica G
(author)
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Nordberg, AgnetaKarolinska Institutet
(author)
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Mok, Vincent
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Mroczko, Barbara
(author)
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Wolk, David A
(author)
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Meyer, Philipp T
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Tsolaki, Magda
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Scheltens, Philip
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Verhey, Frans R J
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Visser, Pieter JelleDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands; Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands
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Aarsland, Dag
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Alcolea, Daniel
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Alexander, Myriam
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Almdahl, Ina S
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Arnold, Steven E
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Baldeiras, Inês
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Barthel, Henryk
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van Berckel, Bart N M
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska Academy,Sahlgrenska University Hospital(Swepub:lu)med-kbw
(author)
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van Buchem, Mark A
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Cavedo, Enrica
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Chen, Kewei
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Chipi, Elena
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Cohen, Ann D
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Förster, Stefan
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Fortea, Juan
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Frederiksen, Kristian S
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Freund-Levi, Yvonne,1956-Department of Geriatrics, Karolinska University Hospital Huddinge, Section of Clinical Geriatrics, Institution of NVS, Karolinska Institutet, Stockholm, Sweden,Amyloid Biomarker Study Group(Swepub:oru)yfi
(author)
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Gkatzima, Olymbia
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Gordon, Mark Forrest
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Grimmer, Timo
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Hampel, Harald
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Hausner, Lucrezia
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Hellwig, Sabine
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Herukka, Sanna-Kaisa
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Johannsen, Peter
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Klimkowicz-Mrowiec, Aleksandra
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Köhler, Sebastian
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Koglin, Norman
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van Laere, Koen
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de Leon, Mony
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Lisetti, Viviana
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Maier, Wolfgang
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Marcusson, Jan
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Meulenbroek, Olga
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Møllergård, Hanne M
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Morris, John C
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Nordlund, Arto,1962Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xnorar
(author)
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Novak, Gerald P
(author)
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Paraskevas, George P
(author)
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Perera, Gayan
(author)
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Peters, Oliver
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Ramakers, Inez H G B
(author)
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Rami, Lorena
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Rodríguez-Rodríguez, Eloy
(author)
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Roe, Catherine M
(author)
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Rot, Uros
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Rüther, Eckart
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Santana, Isabel
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Schröder, Johannes
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Seo, Sang W
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Sorininen, Hilkka
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Spiru, Luiza
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Stomrud, ErikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)med-esr
(author)
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Struyfs, Hanne
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Teunissen, Charlotte E
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Vos, Stephanie J B
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van Waalwijk van Doorn, Linda J C
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Waldemar, Gunhild
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Wallin, Åsa K.Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)med-was
(author)
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Wiltfang, Jens
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital,Sahlgrenska Academy(Swepub:lu)med-hiz
(author)
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Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the NetherlandsKlinisk minnesforskning
(creator_code:org_t)
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In:JAMA psychiatry: American Medical Association (AMA)75:1, s. 84-952168-62382168-622X
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Cavedo, Enrica
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JAMA psychiatry
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University of Gothenburg
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Örebro University
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Lund University
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