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Serum neurofilament...
Serum neurofilament light in familial Alzheimer disease: A marker of early neurodegeneration.
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Weston, Philip S J (author)
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Poole, Teresa (author)
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Ryan, Natalie S (author)
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Nair, Akshay (author)
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Liang, Yuying (author)
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Macpherson, Kirsty (author)
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Druyeh, Ronald (author)
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Malone, Ian B (author)
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Ahsan, R Laila (author)
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Pemberton, Hugh (author)
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Klimova, Jana (author)
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Mead, Simon (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Rossor, Martin N (author)
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Schott, Jonathan M (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Fox, Nick C (author)
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(creator_code:org_t)
- 2017
- 2017
- English.
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In: Neurology. - 1526-632X. ; 89:21, s. 2167-2175
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- To investigate whether serum neurofilament light (NfL) concentration is increased in familial Alzheimer disease (FAD), both pre and post symptom onset, and whether it is associated with markers of disease stage and severity.We recruited 48 individuals from families with PSEN1 or APP mutations to a cross-sectional study: 18 had symptomatic Alzheimer disease (AD) and 30 were asymptomatic but at 50% risk of carrying a mutation. Serum NfL was measured using an ultrasensitive immunoassay on the single molecule array (Simoa) platform. Cognitive testing and MRI were performed; 33 participants had serial MRI, allowing calculation of atrophy rates. Genetic testing established mutation status. A generalized least squares regression model was used to compare serum NfL among symptomatic mutation carriers, presymptomatic carriers, and noncarriers, adjusting for age and sex. Spearman coefficients assessed associations between serum NfL and (1) estimated years to/from symptom onset (EYO), (2) cognitive measures, and (3) MRI measures of atrophy.Nineteen of the asymptomatic participants were mutation carriers (mean EYO -9.6); 11 were noncarriers. Compared with noncarriers, serum NfL concentration was higher in both symptomatic (p < 0.0001) and presymptomatic mutation carriers (p = 0.007). Across all mutation carriers, serum NfL correlated with EYO (ρ = 0.81, p < 0.0001) and multiple cognitive and imaging measures, including Mini-Mental State Examination (ρ = -0.62, p = 0.0001), Clinical Dementia Rating Scale sum of boxes (ρ = 0.79, p < 0.0001), baseline brain volume (ρ = -0.62, p = 0.0002), and whole-brain atrophy rate (ρ = 0.53, p = 0.01).Serum NfL concentration is increased in FAD prior to symptom onset and correlates with measures of disease stage and severity. Serum NfL may thus be a feasible biomarker of early AD-related neurodegeneration.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Adult
- Alzheimer Disease
- blood
- diagnostic imaging
- genetics
- physiopathology
- Amyloid beta-Protein Precursor
- genetics
- Cross-Sectional Studies
- Disease Progression
- Family Health
- Female
- Humans
- Image Processing
- Computer-Assisted
- Magnetic Resonance Imaging
- Male
- Mental Status Schedule
- Middle Aged
- Neurodegenerative Diseases
- blood
- diagnostic imaging
- etiology
- Neurofilament Proteins
- blood
- Neuropsychological Tests
- Presenilin-1
- genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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Neurology
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- By the author/editor
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Weston, Philip S ...
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Poole, Teresa
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Ryan, Natalie S
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Nair, Akshay
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Liang, Yuying
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Macpherson, Kirs ...
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show more...
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Druyeh, Ronald
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Malone, Ian B
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Ahsan, R Laila
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Pemberton, Hugh
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Klimova, Jana
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Mead, Simon
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Blennow, Kaj, 19 ...
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Rossor, Martin N
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Schott, Jonathan ...
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Zetterberg, Henr ...
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Fox, Nick C
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neurology
- By the university
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University of Gothenburg