Search: (WFRF:(Tiesler Carla M T)) pers:(Timpson Nicholas J.)
> (2015) >
A novel common vari...
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van der Valk, Ralf J P
(author)
A novel common variant in DCST2 is associated with length in early life and height in adulthood.
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2014-10-03
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Oxford University Press (OUP),2015
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/261471
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https://gup.ub.gu.se/publication/261471URI
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https://doi.org/10.1093/hmg/ddu510DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-24414URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:130808568URI
Supplementary language notes
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 × 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; β = 0.046, SE = 0.008, P = 2.46 × 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 × 10(-4)) and adult height (N = 127 513; P = 1.45 × 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Kreiner-Møller, Eskil
(author)
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Kooijman, Marjolein N
(author)
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Guxens, Mònica
(author)
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Stergiakouli, Evangelia
(author)
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Sääf, Annika
(author)
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Bradfield, Jonathan P
(author)
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Geller, Frank
(author)
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Hayes, M Geoffrey
(author)
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Cousminer, Diana L
(author)
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Körner, Antje
(author)
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Thiering, Elisabeth
(author)
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Curtin, John A
(author)
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Myhre, Ronny
(author)
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Huikari, Ville
(author)
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Joro, Raimo
(author)
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Kerkhof, Marjan
(author)
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Warrington, Nicole M
(author)
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Pitkänen, Niina
(author)
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Ntalla, Ioanna
(author)
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Horikoshi, Momoko
(author)
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Veijola, Riitta
(author)
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Freathy, Rachel M
(author)
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Teo, Yik-Ying
(author)
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Barton, Sheila J
(author)
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Evans, David MKarolinska Institutet
(author)
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Kemp, John P
(author)
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St Pourcain, Beate
(author)
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Ring, Susan M
(author)
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Davey Smith, George
(author)
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Bergström, AnnaKarolinska Institutet
(author)
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Kull, IngerKarolinska Institutet
(author)
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Hakonarson, Hakon
(author)
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Mentch, Frank D
(author)
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Bisgaard, Hans
(author)
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Chawes, Bo
(author)
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Stokholm, Jakob
(author)
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Waage, Johannes
(author)
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Eriksen, Patrick
(author)
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Sevelsted, Astrid
(author)
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Melbye, Mads
(author)
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van Duijn, Cornelia M
(author)
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Medina-Gomez, Carolina
(author)
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Hofman, Albert
(author)
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de Jongste, Johan C
(author)
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Taal, H Rob
(author)
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Uitterlinden, André G
(author)
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Armstrong, Loren L
(author)
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Eriksson, Johan
(author)
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Palotie, Aarno
(author)
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Bustamante, Mariona
(author)
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Estivill, Xavier
(author)
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Gonzalez, Juan R
(author)
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Llop, Sabrina
(author)
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Kiess, Wieland
(author)
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Mahajan, Anubha
(author)
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Flexeder, Claudia
(author)
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Tiesler, Carla M T
(author)
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Murray, Clare S
(author)
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Simpson, Angela
(author)
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Magnus, Per
(author)
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Sengpiel, Verena,1977Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xsenve
(author)
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Hartikainen, Anna-Liisa
(author)
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Keinanen-Kiukaanniemi, Sirkka
(author)
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Lewin, Alexandra
(author)
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Da Silva Couto Alves, Alexessander
(author)
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Blakemore, Alexandra I
(author)
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Buxton, Jessica L
(author)
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Kaakinen, Marika
(author)
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Rodriguez, AlinaMittuniversitetet,Avdelningen för psykologi(Swepub:miun)alirod
(author)
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Sebert, Sylvain
(author)
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Vaarasmaki, Marja
(author)
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Lakka, Timo
(author)
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Lindi, Virpi
(author)
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Gehring, Ulrike
(author)
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Postma, Dirkje S
(author)
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Ang, Wei
(author)
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Newnham, John P
(author)
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Lyytikäinen, Leo-Pekka
(author)
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Pahkala, Katja
(author)
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Raitakari, Olli T
(author)
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Panoutsopoulou, Kalliope
(author)
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Zeggini, Eleftheria
(author)
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Boomsma, Dorret I
(author)
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Groen-Blokhuis, Maria
(author)
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Ilonen, Jorma
(author)
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Franke, Lude
(author)
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Hirschhorn, Joel N
(author)
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Pers, Tune H
(author)
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Liang, Liming
(author)
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Huang, Jinyan
(author)
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Hocher, Berthold
(author)
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Knip, Mikael
(author)
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Saw, Seang-Mei
(author)
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Holloway, John W
(author)
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Melén, Erik
(author)
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Grant, Struan F A
(author)
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Feenstra, Bjarke
(author)
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Lowe, William L
(author)
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Widén, Elisabeth
(author)
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Sergeyev, Elena
(author)
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Grallert, Harald
(author)
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Custovic, Adnan
(author)
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Jacobsson, Bo,1960Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xjacbo
(author)
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Jarvelin, Marjo-Riitta
(author)
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Atalay, Mustafa
(author)
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Koppelman, Gerard H
(author)
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Pennell, Craig E
(author)
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Niinikoski, Harri
(author)
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Dedoussis, George V
(author)
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Mccarthy, Mark I
(author)
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Frayling, Timothy M
(author)
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Sunyer, Jordi
(author)
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Timpson, Nicholas J
(author)
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Rivadeneira, Fernando
(author)
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Bønnelykke, Klaus
(author)
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Jaddoe, Vincent W V
(author)
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Karolinska InstitutetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi
(creator_code:org_t)
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In:Human molecular genetics: Oxford University Press (OUP)24:4, s. 1155-681460-20830964-6906
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van der Valk, Ra ...
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Kreiner-Møller, ...
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Guxens, Mònica
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Stergiakouli, Ev ...
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Sääf, Annika
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Mentch, Frank D
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Murray, Clare S
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Simpson, Angela
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Magnus, Per
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Hartikainen, Ann ...
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Keinanen-Kiukaan ...
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Raitakari, Olli ...
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Panoutsopoulou, ...
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Pers, Tune H
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Huang, Jinyan
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Hocher, Berthold
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Holloway, John W
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Melén, Erik
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Grant, Struan F ...
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Jacobsson, Bo, 1 ...
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Jarvelin, Marjo- ...
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Koppelman, Gerar ...
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