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Sökning: WFRF:(Bønnelykke Klaus) > Vaginal dysbiosis i...

Vaginal dysbiosis in pregnancy associates with risk of emergency caesarean section: a prospective cohort study

Haahr, Thor (författare)
Department of Clinical Medicine, Aarhus University, Denmark and the Fertility Clinic, Skive Regional Hospital, Skive, Denmark
Clausen, Tine Dalsgaard (författare)
Department of Gynaecology and Obstetrics, Nordsjællands Hospital, University of Copenhagen, Hillerød, Denmark
Thorsen, Jonathan (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
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Rasmussen, Morten A. (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; Section of Chemometrics and Analytical Technologies, Department of Food Science, University of Copenhagen, Frederiksberg C, Denmark
Mortensen, Martin S (författare)
Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark
Lehtimäki, Jenni (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
Shah, Shiraz A. (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
Hjelmsø, Mathis H (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
Bønnelykke, Klaus (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
Chawes, Bo L. (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
Vestergaard, Gisle (författare)
Department of Health Technology, Technical University of Denmark, Lyngby, Denmark
Jacobsson, Bo, 1960 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Larsson, Per-Göran, 1953- (författare)
Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Department of Obstetrics and Gynecology, Skaraborg Hospital Skövde, Skövde, Sweden
Brix, Susanne (författare)
Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark
Sørensen, Søren J (författare)
Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark
Bisgaard, Hans (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
Stokholm, Jakob (författare)
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; Section of Microbiology and Fermentation, Department of Food Science, University of Copenhagen, Frederiksberg C, Denmark. Electronic address stokholm@copsac.com
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 (creator_code:org_t)
Oxford, United Kingdom : Elsevier, 2022
2022
Engelska.
Ingår i: Clinical Microbiology and Infection. - Oxford, United Kingdom : Elsevier. - 1198-743X .- 1469-0691. ; 28:4, s. 588-595
Relaterad länk:
http://www.clinicalm...
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https://urn.kb.se/re...
https://doi.org/10.1...
https://gup.ub.gu.se...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Objectives: To investigate changes in vaginal microbiota during pregnancy, and the association between vaginal dysbiosis and reproductive outcomes.Methods: A total of 730 (week 24) and 666 (week 36) vaginal samples from 738 unselected pregnant women were studied by microscopy (Nugent score) and characterized by 16S rRNA gene sequencing. A novel continuous vaginal dysbiosis score was developed based on these methods using a supervised partial least squares model.Results: Among women with bacterial vaginosis in week 24 (n = 53), 47% (n = 25) also had bacterial vaginosis in week 36. In contrast, among women without bacterial vaginosis in week 24, only 3% (n = 18) developed bacterial vaginosis in week 36. Vaginal samples dominated by Lactobacillus crispatus (OR 0.35, 95% CI 0.20–0.60) and Lactobacillus iners (OR 0.40, 95% CI 0.23–0.68) in week 24 were significantly more stable by week 36 when compared with other vaginal community state types. Vaginal dysbiosis score at week 24 was associated with a significant increased risk of emergency, but not elective, caesarean section (OR 1.37, 955 CI 1.15–1.64, p < 0.001), suggesting a 37% increased risk per standard deviation increase in vaginal dysbiosis score.Conclusions: Changes in vaginal microbiota from week 24 to week 36 of pregnancy correlated with bacterial vaginosis status and vaginal community state type. A novel vaginal dysbiosis score was associated with a significantly increased risk of emergency, but not elective, caesarean section. This was not found for bacterial vaginosis or any vaginal community state type and could point to the importance of investigating vaginal dysbiosis as a nuanced continuum instead of crude clusters. 

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Nyckelord

Bacterial vaginosis; Mode of delivery; Pregnancy; Preterm delivery; Vaginal microbiome; Vaginal microbiota

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