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A novel common vari...
A novel common variant in DCST2 is associated with length in early life and height in adulthood.
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van der Valk, Ralf J P (author)
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Kreiner-Møller, Eskil (author)
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Kooijman, Marjolein N (author)
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show more...
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Guxens, Mònica (author)
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Stergiakouli, Evangelia (author)
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Sääf, Annika (author)
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Bradfield, Jonathan P (author)
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Geller, Frank (author)
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Hayes, M Geoffrey (author)
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Cousminer, Diana L (author)
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Körner, Antje (author)
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Thiering, Elisabeth (author)
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Curtin, John A (author)
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Myhre, Ronny (author)
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Huikari, Ville (author)
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Joro, Raimo (author)
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Kerkhof, Marjan (author)
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Warrington, Nicole M (author)
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Pitkänen, Niina (author)
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Ntalla, Ioanna (author)
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Horikoshi, Momoko (author)
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Veijola, Riitta (author)
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Freathy, Rachel M (author)
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Teo, Yik-Ying (author)
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Barton, Sheila J (author)
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- Evans, David M (author)
- Karolinska Institutet
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Kemp, John P (author)
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St Pourcain, Beate (author)
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Ring, Susan M (author)
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Davey Smith, George (author)
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- Bergström, Anna (author)
- Karolinska Institutet
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- Kull, Inger (author)
- Karolinska Institutet
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Hakonarson, Hakon (author)
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Mentch, Frank D (author)
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Bisgaard, Hans (author)
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Chawes, Bo (author)
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Stokholm, Jakob (author)
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Waage, Johannes (author)
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Eriksen, Patrick (author)
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Sevelsted, Astrid (author)
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Melbye, Mads (author)
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van Duijn, Cornelia M (author)
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Medina-Gomez, Carolina (author)
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Hofman, Albert (author)
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de Jongste, Johan C (author)
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Taal, H Rob (author)
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Uitterlinden, André G (author)
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Armstrong, Loren L (author)
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Eriksson, Johan (author)
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Palotie, Aarno (author)
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Bustamante, Mariona (author)
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Estivill, Xavier (author)
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Gonzalez, Juan R (author)
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Llop, Sabrina (author)
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Kiess, Wieland (author)
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Mahajan, Anubha (author)
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Flexeder, Claudia (author)
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Tiesler, Carla M T (author)
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Murray, Clare S (author)
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Simpson, Angela (author)
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Magnus, Per (author)
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- Sengpiel, Verena, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Hartikainen, Anna-Liisa (author)
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Keinanen-Kiukaanniemi, Sirkka (author)
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Lewin, Alexandra (author)
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Da Silva Couto Alves, Alexessander (author)
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Blakemore, Alexandra I (author)
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Buxton, Jessica L (author)
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Kaakinen, Marika (author)
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- Rodriguez, Alina (author)
- Mittuniversitetet,Avdelningen för psykologi
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Sebert, Sylvain (author)
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Vaarasmaki, Marja (author)
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Lakka, Timo (author)
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Lindi, Virpi (author)
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Gehring, Ulrike (author)
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Postma, Dirkje S (author)
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Ang, Wei (author)
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Newnham, John P (author)
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Lyytikäinen, Leo-Pekka (author)
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Pahkala, Katja (author)
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Raitakari, Olli T (author)
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Panoutsopoulou, Kalliope (author)
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Zeggini, Eleftheria (author)
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Boomsma, Dorret I (author)
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Groen-Blokhuis, Maria (author)
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Ilonen, Jorma (author)
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Franke, Lude (author)
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Hirschhorn, Joel N (author)
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Pers, Tune H (author)
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Liang, Liming (author)
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Huang, Jinyan (author)
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Hocher, Berthold (author)
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Knip, Mikael (author)
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Saw, Seang-Mei (author)
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Holloway, John W (author)
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Melén, Erik (author)
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Grant, Struan F A (author)
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Feenstra, Bjarke (author)
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Lowe, William L (author)
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Widén, Elisabeth (author)
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Sergeyev, Elena (author)
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Grallert, Harald (author)
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Custovic, Adnan (author)
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- Jacobsson, Bo, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Jarvelin, Marjo-Riitta (author)
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Atalay, Mustafa (author)
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Koppelman, Gerard H (author)
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Pennell, Craig E (author)
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Niinikoski, Harri (author)
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Dedoussis, George V (author)
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Mccarthy, Mark I (author)
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Frayling, Timothy M (author)
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Sunyer, Jordi (author)
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Timpson, Nicholas J (author)
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Rivadeneira, Fernando (author)
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Bønnelykke, Klaus (author)
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Jaddoe, Vincent W V (author)
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(creator_code:org_t)
- 2014-10-03
- 2015
- English.
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In: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 24:4, s. 1155-68
- Related links:
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https://academic.oup...
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https://doi.org/10.1...
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https://miun.diva-po... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 × 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; β = 0.046, SE = 0.008, P = 2.46 × 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 × 10(-4)) and adult height (N = 127 513; P = 1.45 × 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Keyword
- Adaptor Proteins
- Signal Transducing
- genetics
- metabolism
- Adult
- Age Factors
- Alleles
- Body Height
- genetics
- Computational Biology
- Databases
- Genetic
- Genetic Association Studies
- Genetic Variation
- Genotype
- Humans
- Infant
- Newborn
- Membrane Proteins
- genetics
- metabolism
- Phenotype
- Polymorphism
- Single Nucleotide
- Quantitative Trait Loci
- Quantitative Trait
- Heritable
- Reproducibility of Results
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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van der Valk, Ra ...
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Kreiner-Møller, ...
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Kooijman, Marjol ...
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Guxens, Mònica
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Stergiakouli, Ev ...
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Sääf, Annika
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show more...
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Bradfield, Jonat ...
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Geller, Frank
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Hayes, M Geoffre ...
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Cousminer, Diana ...
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Körner, Antje
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Thiering, Elisab ...
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Curtin, John A
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Myhre, Ronny
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Huikari, Ville
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Joro, Raimo
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Kerkhof, Marjan
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Warrington, Nico ...
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Pitkänen, Niina
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Ntalla, Ioanna
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Horikoshi, Momok ...
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Veijola, Riitta
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Freathy, Rachel ...
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Teo, Yik-Ying
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Barton, Sheila J
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Evans, David M
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Kemp, John P
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St Pourcain, Bea ...
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Ring, Susan M
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Davey Smith, Geo ...
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Bergström, Anna
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Kull, Inger
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Hakonarson, Hako ...
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Mentch, Frank D
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Bisgaard, Hans
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Chawes, Bo
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Stokholm, Jakob
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Waage, Johannes
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Eriksen, Patrick
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Sevelsted, Astri ...
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Melbye, Mads
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van Duijn, Corne ...
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Medina-Gomez, Ca ...
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Hofman, Albert
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de Jongste, Joha ...
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Taal, H Rob
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Uitterlinden, An ...
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Armstrong, Loren ...
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Eriksson, Johan
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Palotie, Aarno
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Bustamante, Mari ...
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Estivill, Xavier
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Gonzalez, Juan R
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Llop, Sabrina
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Kiess, Wieland
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Mahajan, Anubha
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Flexeder, Claudi ...
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Tiesler, Carla M ...
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Murray, Clare S
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Simpson, Angela
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Magnus, Per
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Sengpiel, Verena ...
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Hartikainen, Ann ...
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Keinanen-Kiukaan ...
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Lewin, Alexandra
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Da Silva Couto A ...
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Blakemore, Alexa ...
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Buxton, Jessica ...
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Kaakinen, Marika
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Rodriguez, Alina
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Sebert, Sylvain
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Vaarasmaki, Marj ...
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Lakka, Timo
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Lindi, Virpi
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Gehring, Ulrike
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Postma, Dirkje S
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Ang, Wei
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Newnham, John P
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Lyytikäinen, Leo ...
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Pahkala, Katja
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Raitakari, Olli ...
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Panoutsopoulou, ...
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Zeggini, Elefthe ...
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Boomsma, Dorret ...
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Groen-Blokhuis, ...
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Ilonen, Jorma
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Franke, Lude
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Hirschhorn, Joel ...
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Pers, Tune H
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Liang, Liming
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Huang, Jinyan
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Hocher, Berthold
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Knip, Mikael
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Saw, Seang-Mei
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Holloway, John W
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Melén, Erik
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Grant, Struan F ...
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Feenstra, Bjarke
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Lowe, William L
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Widén, Elisabeth
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Sergeyev, Elena
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Grallert, Harald
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Custovic, Adnan
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Jacobsson, Bo, 1 ...
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Jarvelin, Marjo- ...
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Atalay, Mustafa
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Koppelman, Gerar ...
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Pennell, Craig E
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Niinikoski, Harr ...
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Dedoussis, Georg ...
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Mccarthy, Mark I
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Frayling, Timoth ...
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Sunyer, Jordi
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Timpson, Nichola ...
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Rivadeneira, Fer ...
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Bønnelykke, Klau ...
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Jaddoe, Vincent ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
- Articles in the publication
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Human molecular ...
- By the university
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University of Gothenburg
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Mid Sweden University
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Karolinska Institutet