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Performance of nove...
Performance of novel collagen turnover biomarkers to detect increased liver stiffness in MASLD
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- Hegmar, Hannes (författare)
- Division of Hepatology, Department of Upper GI, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden
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- Wiggers, Thomas (författare)
- Nordic Bioscience, Herlev, Denmark
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- Nasr, Patrik (författare)
- Department of Gastroenterology and Hepatology, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
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- Vessby, Johan (författare)
- Department of Medical Sciences, Gastroenterology Research Group, Uppsala University, Uppsala, Sweden
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- Kechagias, Stergios (författare)
- Department of Gastroenterology and Hepatology, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
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- Nyhlin, Nils, 1971- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology
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- Marschall, Hanns-Ulrich (författare)
- Sahlgrenska University Hospital, Gothenburg, Sweden
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- Borssén, Åsa Danielsson (författare)
- Umeå University Hospital, Umeå, Sweden
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- Strandberg, Rickard (författare)
- Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden
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- Karsdal, Morten (författare)
- Nordic Bioscience, Herlev, Denmark
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- Leeming, Diana Julie (författare)
- Nordic Bioscience, Herlev, Denmark
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- Ekstedt, Mattias (författare)
- Department of Gastroenterology and Hepatology, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
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- Hagström, Hannes (författare)
- Division of Hepatology, Department of Upper GI, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Journal of Internal Medicine. - : Wiley-Blackwell. - 0954-6820 .- 1365-2796.
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Cleavage products from collagen formation and degradation hold potential as first-line biomarkers for the risk of advanced fibrosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we evaluated the performance of PRO-C3, PRO-C6, C4M, PRO-C18L, and the clinical score ADAPT (age, diabetes, PRO-C3, and platelet count) to detect patients with an LSM >8 kPa or >12 kPa in comparison to the Fibrosis-4 Index (FIB-4).METHODS: Serum from patients with MASLD (n = 269) from six Swedish University Hospitals was analyzed using enzyme-linked immunosorbent assay-based methods. Liver stiffness measurement (LSM) by vibration-controlled transient elastography was performed. The area under the curve (AUC), calibration curves, and net benefit analysis were used.RESULTS: An LSM >8 kPa was found in 108 (40.1%) patients. PRO-C3, PRO-C6, C4M, and PRO-C18L had AUCs ranging from 0.48 to 0.62. ADAPT had the highest AUC (0.73, 95% confidence interval [CI] = 0.67-0.79) to detect patients >8 kPa, compared to FIB-4 (0.71, (95%CI = 0.64-0.77, p = 0.35), and had a higher net benefit compared to FIB-4 from a probability threshold of 15%. FIB-4 and ADAPT performed equally well to detect patients with an LSM >12 kPa, AUC 0.76 versus 0.76, p = 0.93.CONCLUSIONS: ADAPT seems to be marginally better than FIB-4 in identifying patients with an LSM >8 kPa. However, the clinical utility of ADAPT as a first line test is uncertain, especially in low-risk populations. The overall performance of FIB-4 was similar to that of ADAPT in detecting patients with an LSM of >12 kPa. Altogether, the results suggest that ADAPT might be useful to detect earlier stages of fibrosis in MASLD, but that FIB-4 remains a first-line test for advanced fibrosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- MASLD
- NAFLD
- liver fibrosis
- noninvasive tests
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Hegmar, Hannes
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Wiggers, Thomas
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Nasr, Patrik
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Vessby, Johan
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Kechagias, Sterg ...
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Nyhlin, Nils, 19 ...
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Marschall, Hanns ...
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Borssén, Åsa Dan ...
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Strandberg, Rick ...
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Karsdal, Morten
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Leeming, Diana J ...
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Ekstedt, Mattias
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Hagström, Hannes
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Örebro universitet