Freeze-dried Lactobacillus plantarum 299v increases iron absorption in young females-Double isotope sequential single-blind studies in menstruating women

• Background The probiotic strain Lactobacillus plantarum 299v has earlier been shown to increase iron absorption when added to foods. However, it is not known if the same probiotic strain in a freeze-dried format included in a capsule increases the iron absorption. The aim of this study was to test the hypotheses that non-heme iron absorption from a light meal is promoted by a simultaneous intake of freeze-dried Lactobacillus plantarum 299v (Lp299v, DSM 9843). With a single blinded placebo controlled sequential design, iron absorption from a light breakfast meal administered with or without capsules containing 10(10) cfu freeze-dried Lp299v was studied in healthy female volunteers of fertile age. The methodology used was a double isotope technique (59 Fe and 55 Fe). Two studies were performed using the same protocol. In study 1, the absorption of iron from a meal without Lp299v was found to be 17.4 +/- 13.4%, and from an identical meal with Lp299v was found to be 22.4 +/- 17.3% (mean +/- SD). This difference was statistically significant (p = 0.040, n = 14). In study 2, the absorption of iron from a meal without Lp299v was found to be 20.9 +/- 13.1%, and from an identical meal with Lp299v found to be 24.5 +/- 12.0% (mean +/- SD, n = 28), which again was statistically significant (p = 0.003). Freeze-dried Lp299v enhances the absorption of iron when administered together with a meal with a high iron bioavailability.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Nyckelord

2 radioiron isotopes

nonheme-iron

nonanemic women

childbearing age

gut microbiota

serum ferritin

ascorbic-acid

dietary iron

whole diet

deficiency

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)