Freeze-dried Lactobacillus plantarum 299v increases iron absorption in young females-Double isotope sequential single-blind studies in menstruating women

Hoppe, Michael,1969University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska University Hospital (författare)

Background The probiotic strain Lactobacillus plantarum 299v has earlier been shown to increase iron absorption when added to foods. However, it is not known if the same probiotic strain in a freeze-dried format included in a capsule increases the iron absorption. The aim of this study was to test the hypotheses that non-heme iron absorption from a light meal is promoted by a simultaneous intake of freeze-dried Lactobacillus plantarum 299v (Lp299v, DSM 9843). With a single blinded placebo controlled sequential design, iron absorption from a light breakfast meal administered with or without capsules containing 10(10) cfu freeze-dried Lp299v was studied in healthy female volunteers of fertile age. The methodology used was a double isotope technique (59 Fe and 55 Fe). Two studies were performed using the same protocol. In study 1, the absorption of iron from a meal without Lp299v was found to be 17.4 +/- 13.4%, and from an identical meal with Lp299v was found to be 22.4 +/- 17.3% (mean +/- SD). This difference was statistically significant (p = 0.040, n = 14). In study 2, the absorption of iron from a meal without Lp299v was found to be 20.9 +/- 13.1%, and from an identical meal with Lp299v found to be 24.5 +/- 12.0% (mean +/- SD, n = 28), which again was statistically significant (p = 0.003). Freeze-dried Lp299v enhances the absorption of iron when administered together with a meal with a high iron bioavailability.

Önning, GunillaLund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Probi AB(Swepub:lu)inl-gon (författare)
Hulthén, Lena,1947University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xhulen (författare)
Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition (creator_code:org_t)

Av författaren/redakt...: Hoppe, Michael, ...; Önning, Gunilla; Hulthén, Lena, 1 ...

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