Polymorphisms in dopamine-associated genes and cognitive decline in Parkinson's disease

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Bäckström, DavidUmeå universitet,Klinisk neurovetenskap (author)

Polymorphisms in dopamine-associated genes and cognitive decline in Parkinson's disease

Article/chapterEnglish2018

Publisher, publication year, extent ...

2017-09-04
Hindawi Limited,2018

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LIBRIS-ID:oai:gup.ub.gu.se/262442
https://gup.ub.gu.se/publication/262442URI
https://doi.org/10.1111/ane.12812DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-143002URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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ObjectivesCognitive decline is common in Parkinson's disease (PD), but the underlying mechanisms for this complication are incompletely understood. Genotypes affecting dopamine transmission may be of importance. This study investigates whether genotypes associated with reduced prefrontal dopaminergic tone and/or reduced dopamine D2-receptor availability (Catechol-O-methyltransferase [COMT] Val(158)Met genotype and DRD2 (CT)-T-957 genotype) affect the development of cognitive deficits in PD. Materials and methodsOne hundred and 34 patients with idiopathic PD, participating in a regional, population-based study of incident parkinsonism, underwent genotyping. After extensive baseline investigations (including imaging and biomarker analyses), the patients were followed prospectively during 6-10 years with neuropsychological evaluations, covering six cognitive domains. Cognitive decline (defined as the incidence of either Parkinson's disease mild cognitive impairment [PD-MCI] or dementia [PDD], diagnosed according to published criteria and blinded to genotype) was studied as the primary outcome. ResultsBoth genotypes affected cognition, as shown by Cox proportional hazards models. While the COMT(158)Val/Val genotype conferred an increased risk of mild cognitive impairment in patients with normal cognition at baseline (hazard ratio: 2.13, P=.023), the DRD2(957)T/T genotype conferred an overall increased risk of PD dementia (hazard ratio: 3.22, P<.001). The poorer cognitive performance in DRD2(957)T/T carriers with PD occurred mainly in episodic memory and attention. ConclusionsThe results favor the hypothesis that dopamine deficiency in PD not only relate to mild cognitive deficits in frontostriatal functions, but also to a decline in memory and attention. This could indicate that dopamine deficiency impairs a wide network of brain areas.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
COMT
dementia
DRD2
mild cognitive impairment
neurodegeneration
Parkinson's disease
comt val(158)met genotype
long-term-memory
diagnostic-criteria
messenger-rna
impairment
dementia
brain
schizophrenia
dysfunction
mutations
COMT

Added entries (persons, corporate bodies, meetings, titles ...)

Eriksson Domellöf, MagdalenaUmeå universitet,Klinisk neurovetenskap(Swepub:umu)maaeon98 (author)
Granåsen, GabrielUmeå universitet,Epidemiologi och global hälsa(Swepub:umu)galgrn00 (author)
Linder, JanUmeå universitet,Klinisk neurovetenskap(Swepub:umu)jali0020 (author)
Mayans, SofiaUmeå universitet,Institutionen för klinisk mikrobiologi(Swepub:umu)soma0002 (author)
Elgh, EvaUmeå universitet,Institutionen för psykologi(Swepub:umu)eveg0001 (author)
Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
Forsgren, LarsUmeå universitet,Klinisk neurovetenskap(Swepub:umu)lafo0001 (author)
Umeå universitetKlinisk neurovetenskap (creator_code:org_t)

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In:Acta Neurologica Scandinavica: Hindawi Limited137:1, s. 91-980001-63141600-0404

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By the author/editor: Bäckström, David; Eriksson Domellö ...; Granåsen, Gabrie ...; Linder, Jan; Mayans, Sofia; Elgh, Eva; show more...; Zetterberg, Henr ...; Blennow, Kaj, 19 ...; Forsgren, Lars; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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By the university: University of Gothenburg; Umeå University

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