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Genome-wide associa...
Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2017-10-12
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Stockholm :Wiley,2018
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/262855
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ISSN:0020-7136
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10616/46180hdl
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https://gup.ub.gu.se/publication/262855URI
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https://doi.org/10.1002/ijc.31076DOI
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http://hdl.handle.net/10616/46180URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:137267446URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Genome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in genetic risk. To identify new risk variants and to confirm reported associations, we conducted a genome-wide association study in 1,701 CRC cases and 14,082 cancer-free controls from the Finnish population. A total of 9,068,015 genetic variants were imputed and tested, and 30 promising variants were studied in additional 11,647 cases and 12,356 controls of European ancestry. The previously reported association between the single-nucleotide polymorphism (SNP) rs992157 (2q35) and CRC was independently replicated (p=2.08 x 10(-4); OR, 1.14; 95% CI, 1.06-1.23), and it was genome-wide significant in combined analysis (p=1.50 x 10(-9); OR, 1.12; 95% CI, 1.08-1.16). Variants at 2q35, 6p21.2, 8q23.3, 8q24.21, 10q22.3, 10q24.2, 11q13.4, 11q23.1, 14q22.2, 15q13.3, 18q21.1, 20p12.3 and 20q13.33 were associated with CRC in the Finnish population (false discovery rate<0.1), but new risk loci were not found. These results replicate the effects of multiple loci on the risk of CRC and identify shared risk alleles between the Finnish population isolate and outbred populations.
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van den Berg, L.
(author)
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Valimaki, N.
(author)
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Aavikko, M.
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Ness-Jensen, E.Karolinska Institutet
(author)
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Hveem, K.
(author)
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Wettergren, Yvonne,1957Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery(Swepub:gu)xwetyv
(author)
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Bexe-Lindskog, ElinorGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery(Swepub:gu)xbexel
(author)
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Tonisson, N.
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Metspalu, A.
(author)
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Silander, K.
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Orlando, G.
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Law, P. J.
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Tuupanen, S.
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Gylfe, A. E.
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Hanninen, U. A.
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Cajuso, T.
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Kondelin, J.
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Sarin, A. P.
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Pukkala, E.
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Jousilahti, P.
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Salomaa, V.
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Ripatti, S.
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Palotie, A.
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Jarvinen, H.
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Renkonen-Sinisalo, L.
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Lepisto, A.
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Bohm, J.
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Mecklin, J. P.
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Al-Tassan, N. A.
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Palles, C.
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Martin, L.
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Barclay, E.
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Tenesa, A.
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Farrington, S. M.
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Timofeeva, M. N.
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Meyer, B. F.
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Wakil, S. M.
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Campbell, H.
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Smith, C. G.
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Idziaszczyk, S.
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Maughan, T. S.
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Kaplan, R.
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Kerr, R.
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Kerr, D.
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Buchanan, D. D.
(author)
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Win, A. K.
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Hopper, J.
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Jenkins, M. A.
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Newcomb, P. A.
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Gallinger, S.
(author)
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Conti, D.
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Schumacher, F. R.
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Casey, G.
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Cheadle, J. P.
(author)
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Dunlop, M. G.
(author)
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Tomlinson, I. P.
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Houlston, R. S.
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Palin, K.
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Aaltonen, L. A.
(author)
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Karolinska InstitutetInstitutionen för kliniska vetenskaper, Avdelningen för kirurgi
(creator_code:org_t)
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Karolinska Institutet
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Karolinska Institutet
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In:International Journal of CancerStockholm : Wiley142:3, s. 540-5460020-71361097-0215
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Tanskanen, T.
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van den Berg, L.
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Valimaki, N.
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Aavikko, M.
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Ness-Jensen, E.
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Hveem, K.
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Wettergren, Yvon ...
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Bexe-Lindskog, E ...
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Tonisson, N.
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Metspalu, A.
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Silander, K.
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Orlando, G.
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Law, P. J.
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Tuupanen, S.
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Gylfe, A. E.
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Hanninen, U. A.
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Cajuso, T.
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Kondelin, J.
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Sarin, A. P.
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Pukkala, E.
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Jousilahti, P.
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Salomaa, V.
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Ripatti, S.
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Palotie, A.
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Jarvinen, H.
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Renkonen-Sinisal ...
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Lepisto, A.
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Bohm, J.
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Mecklin, J. P.
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Al-Tassan, N. A.
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Palles, C.
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Martin, L.
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Barclay, E.
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Tenesa, A.
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Farrington, S. M ...
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Timofeeva, M. N.
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Meyer, B. F.
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Wakil, S. M.
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Campbell, H.
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Smith, C. G.
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Idziaszczyk, S.
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Maughan, T. S.
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Kaplan, R.
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Kerr, R.
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Kerr, D.
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Buchanan, D. D.
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Win, A. K.
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Hopper, J.
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Jenkins, M. A.
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Newcomb, P. A.
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Gallinger, S.
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Conti, D.
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Schumacher, F. R ...
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Casey, G.
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Cheadle, J. P.
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Dunlop, M. G.
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Tomlinson, I. P.
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Houlston, R. S.
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Palin, K.
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Aaltonen, L. A.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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University of Gothenburg
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Karolinska Institutet