Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Tyrrell J.) > Genome-wide associa...

Details
MARC

Beaumont, Robin N (author)

Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.

Article/chapterEnglish2018

Publisher, publication year, extent ...

2018-01-03
Oxford University Press (OUP),2018

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/264060
https://gup.ub.gu.se/publication/264060URI
https://doi.org/10.1093/hmg/ddx429DOI

Supplementary language notes

Language:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Genome-wide association studies (GWAS) of birth weight have focused on fetal genetics, while relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated with birth weight that could highlight potentially relevant maternal determinants of fetal growth. We meta-analysed data on up to 8.7 million SNPs in up to 86,577 women of European descent from the Early Growth Genetics (EGG) Consortium and the UK Biobank. We used structural equation modelling (SEM) and analyses of mother-child pairs to quantify the separate maternal and fetal genetic effects. Maternal SNPs at 10 loci (MTNR1B, HMGA2, SH2B3, KCNAB1, L3MBTL3, GCK, EBF1, TCF7L2, ACTL9, CYP3A7) were associated with offspring birth weight at P<5x10-8. In SEM analyses, at least 7 of the 10 associations were consistent with effects of the maternal genotype acting via the intrauterine environment, rather than via effects of shared alleles with the fetus. Variants, or correlated proxies, at many of the loci had been previously associated with adult traits, including fasting glucose (MTNR1B, GCK and TCF7L2) and sex hormone levels (CYP3A7), and one (EBF1) with gestational duration. The identified associations indicate genetic effects on maternal glucose, cytochrome P450 activity and gestational duration, and potentially on maternal blood pressure and immune function, are relevant for fetal growth. Further characterization of these associations in mechanistic and causal analyses will enhance understanding of the potentially modifiable maternal determinants of fetal growth, with the goal of reducing the morbidity and mortality associated with low and high birth weights.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

Warrington, Nicole M (author)
Cavadino, Alana (author)
Tyrrell, Jessica (author)
Nodzenski, Michael (author)
Horikoshi, Momoko (author)
Geller, Frank (author)
Myhre, Ronny (author)
Richmond, Rebecca C (author)
Paternoster, Lavinia (author)
Bradfield, Jonathan P (author)
Kreiner-Møller, Eskil (author)
Huikari, Ville (author)
Metrustry, Sarah (author)
Lunetta, Kathryn L (author)
Painter, Jodie N (author)
Hottenga, Jouke-Jan (author)
Allard, Catherine (author)
Barton, Sheila J (author)
Espinosa, Ana (author)
Marsh, Julie A (author)
Potter, Catherine (author)
Zhang, Ge (author)
Ang, Wei (author)
Berry, Diane J (author)
Bouchard, Luigi (author)
Das, Shikta (author)
Hakonarson, Hakon (author)
Heikkinen, Jani (author)
Helgeland, Øyvind (author)
Hocher, Berthold (author)
Hofman, Albert (author)
Inskip, Hazel M (author)
Jones, Samuel E (author)
Kogevinas, Manolis (author)
Lind, Penelope A (author)
Marullo, Letizia (author)
Medland, Sarah E (author)
Murray, Anna (author)
Murray, Jeffrey C (author)
Njølstad, Pål R (author)
Nohr, Ellen A (author)
Reichetzeder, Christoph (author)
Ring, Susan M (author)
Ruth, Katherine S (author)
Santa-Marina, Loreto (author)
Scholtens, Denise M (author)
Sebert, Sylvain (author)
Sengpiel, Verena,1977Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xsenve (author)
Tuke, Marcus A (author)
Vaudel, Marc (author)
Weedon, Michael N (author)
Willemsen, Gonneke (author)
Wood, Andrew R (author)
Yaghootkar, Hanieh (author)
Muglia, Louis J (author)
Bartels, Meike (author)
Relton, Caroline L (author)
Pennell, Craig E (author)
Chatzi, Leda (author)
Estivill, Xavier (author)
Holloway, John W (author)
Boomsma, Dorret I (author)
Montgomery, Grant W (author)
Murabito, Joanne M (author)
Spector, Tim D (author)
Power, Christine (author)
Järvelin, Marjo-Ritta (author)
Bisgaard, Hans (author)
Grant, Struan Fa (author)
Sørensen, Thorkild Ia (author)
Jaddoe, Vincent W (author)
Jacobsson, Bo,1960Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xjacbo (author)
Melbye, Mads (author)
McCarthy, Mark I (author)
Hattersley, Andrew T (author)
Hayes, M Geoffrey (author)
Frayling, Timothy M (author)
Hivert, Marie-France (author)
Felix, Janine F (author)
Hyppönen, Elina (author)
Lowe, William L (author)
Evans, David M (author)
Lawlor, Debbie A (author)
Feenstra, Bjarke (author)
Freathy, Rachel M (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi (creator_code:org_t)

Related titles

In:Human molecular genetics: Oxford University Press (OUP)27:4, s. 742-7561460-20831460-20830964-6906

Internet link

Find in a library

Human molecular genetics (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Beaumont, Robin ...; Warrington, Nico ...; Cavadino, Alana; Tyrrell, Jessica; Nodzenski, Micha ...; Horikoshi, Momok ...; show more...; Geller, Frank; Myhre, Ronny; Richmond, Rebecc ...; Paternoster, Lav ...; Bradfield, Jonat ...; Kreiner-Møller, ...; Huikari, Ville; Metrustry, Sarah; Lunetta, Kathryn ...; Painter, Jodie N; Hottenga, Jouke- ...; Allard, Catherin ...; Barton, Sheila J; Espinosa, Ana; Marsh, Julie A; Potter, Catherin ...; Zhang, Ge; Ang, Wei; Berry, Diane J; Bouchard, Luigi; Das, Shikta; Hakonarson, Hako ...; Heikkinen, Jani; Helgeland, Øyvin ...; Hocher, Berthold; Hofman, Albert; Inskip, Hazel M; Jones, Samuel E; Kogevinas, Manol ...; Lind, Penelope A; Marullo, Letizia; Medland, Sarah E; Murray, Anna; Murray, Jeffrey ...; Njølstad, Pål R; Nohr, Ellen A; Reichetzeder, Ch ...; Ring, Susan M; Ruth, Katherine ...; Santa-Marina, Lo ...; Scholtens, Denis ...; Sebert, Sylvain; Sengpiel, Verena ...; Tuke, Marcus A; Vaudel, Marc; Weedon, Michael ...; Willemsen, Gonne ...; Wood, Andrew R; Yaghootkar, Hani ...; Muglia, Louis J; Bartels, Meike; Relton, Caroline ...; Pennell, Craig E; Chatzi, Leda; Estivill, Xavier; Holloway, John W; Boomsma, Dorret ...; Montgomery, Gran ...; Murabito, Joanne ...; Spector, Tim D; Power, Christine; Järvelin, Marjo- ...; Bisgaard, Hans; Grant, Struan Fa; Sørensen, Thorki ...; Jaddoe, Vincent ...; Jacobsson, Bo, 1 ...; Melbye, Mads; McCarthy, Mark I; Hattersley, Andr ...; Hayes, M Geoffre ...; Frayling, Timoth ...; Hivert, Marie-Fr ...; Felix, Janine F; Hyppönen, Elina; Lowe, William L; Evans, David M; Lawlor, Debbie A; Feenstra, Bjarke; Freathy, Rachel ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

Articles in the publication: Human molecular ...

By the university: University of Gothenburg

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se