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Early Recurrence an...
Early Recurrence and Major Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation Treated With Non-Vitamin-K Oral Anticoagulants (RAF-NOACs) Study
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Paciaroni, M. (author)
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Agnelli, G. (author)
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Falocci, N. (author)
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show more...
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Tsivgoulis, G. (author)
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Vadikolias, K. (author)
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Liantinioti, C. (author)
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Chondrogianni, M. (author)
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Bovi, P. (author)
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Carletti, M. (author)
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Cappellari, M. (author)
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Zedde, M. (author)
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Ntaios, G. (author)
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Karagkiozi, E. (author)
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Athanasakis, G. (author)
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Makaritsis, K. (author)
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Silvestrelli, G. (author)
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Lanari, A. (author)
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Ciccone, A. (author)
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Putaala, J. (author)
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Tomppo, L. (author)
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- Tatlisumak, Turgut (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Abdul-Rahim, A. H. (author)
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Lees, K. R. (author)
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Alberti, A. (author)
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Venti, M. (author)
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Acciarresi, M. (author)
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D'Amore, C. (author)
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Becattini, C. (author)
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Mosconi, M. G. (author)
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Cimini, L. A. (author)
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Soloperto, R. (author)
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Masotti, L. (author)
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Vannucchi, V. (author)
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Lorenzini, G. (author)
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Tassi, R. (author)
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Guideri, F. (author)
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Acampa, M. (author)
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Martini, G. (author)
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Sohn, S. I. (author)
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Marcheselli, S. (author)
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Mumoli, N. (author)
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De Lodovici, M. L. (author)
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Bono, G. (author)
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Furie, K. L. (author)
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Tadi, P. (author)
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Yaghi, S. (author)
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Toni, D. (author)
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Letteri, F. (author)
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Tassinari, T. (author)
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Kargiotis, O. (author)
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Lotti, E. M. (author)
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Flomin, Y. (author)
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Mancuso, M. (author)
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Maccarrone, M. (author)
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Giannini, N. (author)
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Bandini, F. (author)
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Pezzini, A. (author)
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Poli, L. (author)
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Padovani, A. (author)
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Scoditti, U. (author)
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Denti, L. (author)
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Consoli, D. (author)
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Galati, F. (author)
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Sacco, S. (author)
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Carolei, A. (author)
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Tiseo, C. (author)
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Gourbali, V. (author)
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Orlandi, G. (author)
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Giuntini, M. (author)
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Chiti, A. (author)
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Giorli, E. (author)
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Gialdini, G. (author)
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Corea, F. (author)
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Ageno, W. (author)
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Bellesini, M. (author)
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Colombo, G. (author)
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Monaco, S. (author)
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Baronello, M. M. (author)
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Karapanayiotides, T. (author)
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Caso, V. (author)
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2017
- 2017
- English.
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In: Journal of the American Heart Association. - : Ovid Technologies (Wolters Kluwer Health). - 2047-9980. ; 6:12
- Related links:
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https://www.ahajourn...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Background-The optimal timing to administer non-vitamin K oral anticoagulants (NOACs) in patients with acute ischemic stroke and atrial fibrillation is unclear. This prospective observational multicenter study evaluated the rates of early recurrence and major bleeding (within 90 days) and theirtiming in patients with acute ischemic stroke and atrial fibrillation who received NOACs for secondary prevention. Methods and Results-Recurrence was defined as the composite of ischemic stroke, transient ischemic attack, and symptomatic systemic embolism, and major bleeding was defined as symptomatic cerebral and major extracranial bleeding. For the analysis, 1127 patients were eligible: 381 (33.8%) were treated with dabigatran, 366 (32.5%) with rivaroxaban, and 380 (33.7%) with apixaban. Patients who received dabigatran were younger and had lower admission National Institutes of Health Stroke Scale score and less commonly had a CHA(2)DS(2)-VASc score >4 and less reduced renal function. Thirty-two patients (2.8%) had early recurrence, and 27 (2.4%) had major bleeding. The rates of early recurrence and major bleeding were, respectively, 1.8% and 0.5% in patients receiving dabigatran, 1.6% and 2.5% in those receiving rivaroxaban, and 4.0% and 2.9% in those receiving apixaban. Patients who initiated NOACs within 2 days after acute stroke had a composite rate of recurrence and major bleeding of 12.4%; composite rates were 2.1% for those who initiated NOACs between 3 and 14 days and 9.1% for those who initiated > 14 days after acute stroke. Conclusions-In patients with acute ischemic stroke and atrial fibrillation, treatment with NOACs was associated with a combined 5% rate of ischemic embolic recurrence and severe bleeding within 90 days.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- acute stroke
- anticoagulants
- atrial fibrillation
- secondary prevention
- health-care professionals
- hemorrhagic transformation
- arterial
- territories
- writing committee
- early management
- human brain
- task-force
- association
- guidelines
- warfarin
- Cardiovascular System & Cardiology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Paciaroni, M.
-
Agnelli, G.
-
Falocci, N.
-
Tsivgoulis, G.
-
Vadikolias, K.
-
Liantinioti, C.
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show more...
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Chondrogianni, M ...
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Bovi, P.
-
Carletti, M.
-
Cappellari, M.
-
Zedde, M.
-
Ntaios, G.
-
Karagkiozi, E.
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Athanasakis, G.
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Makaritsis, K.
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Silvestrelli, G.
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Lanari, A.
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Ciccone, A.
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Putaala, J.
-
Tomppo, L.
-
Tatlisumak, Turg ...
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Abdul-Rahim, A. ...
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Lees, K. R.
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Alberti, A.
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Venti, M.
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Acciarresi, M.
-
D'Amore, C.
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Becattini, C.
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Mosconi, M. G.
-
Cimini, L. A.
-
Soloperto, R.
-
Masotti, L.
-
Vannucchi, V.
-
Lorenzini, G.
-
Tassi, R.
-
Guideri, F.
-
Acampa, M.
-
Martini, G.
-
Sohn, S. I.
-
Marcheselli, S.
-
Mumoli, N.
-
De Lodovici, M. ...
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Bono, G.
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Furie, K. L.
-
Tadi, P.
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Yaghi, S.
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Toni, D.
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Letteri, F.
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Tassinari, T.
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Kargiotis, O.
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Lotti, E. M.
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Flomin, Y.
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Mancuso, M.
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Maccarrone, M.
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Giannini, N.
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Bandini, F.
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Pezzini, A.
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Poli, L.
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Padovani, A.
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Scoditti, U.
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Denti, L.
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Consoli, D.
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Galati, F.
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Sacco, S.
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Carolei, A.
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Tiseo, C.
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Gourbali, V.
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Orlandi, G.
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Giuntini, M.
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Chiti, A.
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Giorli, E.
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Gialdini, G.
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Corea, F.
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Ageno, W.
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Bellesini, M.
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Colombo, G.
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Monaco, S.
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Baronello, M. M.
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Karapanayiotides ...
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Caso, V.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of the A ...
- By the university
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University of Gothenburg