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Neurological and ne...
Neurological and neuropsychological effects of low and moderate prenatal alcohol exposure
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- Comasco, Erika, 1982- (författare)
- Uppsala universitet,Institutionen för neurovetenskap
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- Rangmar, Jenny (författare)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology,Univ Gothenburg, Dept Psychol, Gothenburg, Sweden
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- Eriksson, Ulf J., 1948- (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Oreland, Lars (författare)
- Uppsala universitet,Institutionen för neurovetenskap
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(creator_code:org_t)
- 2017-05-30
- 2018
- Engelska.
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Ingår i: Acta Physiologica. - : Wiley. - 1748-1708 .- 1748-1716. ; 222:1
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Several explanations for the diverse results in research on foetal alcohol spectrum disorders or alcohol-related neurodevelopmental disorder might be at hand: timing, amount and patterns of alcohol exposure, as well as complex epigenetic responses. The genetic background of the offspring and its interaction with other prenatal and post-natal environmental cues are likely also of importance. In the present report, key findings about the possible effects of low and moderate doses of maternal alcohol intake on the neuropsychological development of the offspring are reviewed and plausible mechanisms discussed. Special focus is put on the serotonergic system within developmental and gene-environment frameworks. The review also suggests guidelines for future studies and also summarizes some of to-be-answered questions of relevance to clinical practice. Contradictory findings and paucity of studies on the effects of exposure to low alcohol levels during foetal life for the offspring's neuropsychological development call for large prospective studies, as well as for studies including neuroimaging and multi-omics analyses to dissect the neurobiological underpinnings of alcohol exposure-related phenotypes and to identify biomarkers. Finally, it remains to be investigated whether any safe threshold of alcohol drinking during pregnancy can be identified.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- alcohol
- development
- epigenetics
- gene
- pregnancy
- prenatal
- serotonin transporter gene
- linked polymorphic region
- cognition-enhancing agent
- messenger-rna expression
- retinoic acid
- exposure
- monoamine-oxidase
- spectrum disorders
- ethanol exposure
- promoter polymorphism
- synaptic plasticity
- alcohol
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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