Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

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MARC

Fuchs, A. (author)

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

Article/chapterEnglish2018

Publisher, publication year, extent ...

2018-01-15
Frontiers Media SA,2018

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/264180
https://gup.ub.gu.se/publication/264180URI
https://doi.org/10.3389/fimmu.2017.01844DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-342893URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While the number of clinical trials testing Tregs is already substantial, it seems to be crucial to provide some standardized characteristics of Treg products in order to minimize the problem. We have previously developed reporting guidelines called minimum information about tolerogenic antigen-presenting cells, which allows the comparison between different preparations of tolerance-inducing antigen-presenting cells. Having this experience, here we describe another minimum information about Tregs (MITREG). It is important to note that MITREG does not dictate how investigators should generate or characterize Tregs, but it does require investigators to report their Treg data in a consistent and transparent manner. We hope this will, therefore, be a useful tool facilitating standardized reporting on the manufacturing of Tregs, either for research purposes or for clinical application. This way MITREG might also be an important step toward more standardized and reproducible testing of the Tregs preparations in clinical applications.

Subject headings and genre

LANTBRUKSVETENSKAPER Veterinärmedicin Patobiologi hsv//swe
AGRICULTURAL SCIENCES Veterinary Science Pathobiology hsv//eng
minimum information model
T regulatory cells
immunotherapy
good manufacturing practice
cell
chimeric antigen receptor
versus-host-disease
adoptive transfer
in-vitro
transplantation
blood
expansion
allograft
tolerance
therapies
Immunology
T regulatory cells

Added entries (persons, corporate bodies, meetings, titles ...)

Gliwinski, M. (author)
Grageda, N. (author)
Spiering, R. (author)
Abbas, A. K. (author)
Appel, S. (author)
Bacchetta, R. (author)
Battaglia, M. (author)
Berglund, David,1984-Uppsala universitet,Klinisk immunologi(Swepub:uu)davbe892 (author)
Blazar, B. (author)
Bluestone, J. A. (author)
Bornhauser, M. (author)
ten Brinke, A. (author)
Brusko, T. M. (author)
Cools, N. (author)
Cuturi, M. C. (author)
Geissler, E. (author)
Giannoukakis, N. (author)
Golab, K. (author)
Hafler, D. A. (author)
van Ham, S. M. (author)
Hester, J. (author)
Hippen, K. (author)
Di Ianni, M. (author)
Ilic, N. (author)
Isaacs, J. (author)
Issa, F. (author)
Iwaszkiewicz-Grzes, D. (author)
Jaeckel, E. (author)
Joosten, I. (author)
Klatzmann, D. (author)
Koenen, H. (author)
van Kooten, C. (author)
Korsgren, OlleUppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,Klinisk immunologi(Swepub:uu)ollekors (author)
Kretschmer, K. (author)
Levings, M. (author)
Marek-Trzonkowska, N. M. (author)
Martinez-Llordella, M. (author)
Miljkovic, D. (author)
Mills, K. H. G. (author)
Miranda, J. P. (author)
Piccirillo, C. A. (author)
Putnam, A. L. (author)
Ritter, T. (author)
Roncarolo, M. G. (author)
Sakaguchi, S. (author)
Sanchez-Ramon, S. (author)
Sawitzki, B. (author)
Sofronic-Milosavljevic, L. (author)
Sykes, M. (author)
Tang, Q. Z. (author)
Vives-Pi, M. (author)
Waldmann, H. (author)
Witkowski, P. (author)
Wood, K. J. (author)
Gregori, S. (author)
Hilkens, C. M. U. (author)
Lombardi, G. (author)
Lord, P. (author)
Martinez-Caceres, E. M. (author)
Trzonkowski, P. (author)
Uppsala universitetKlinisk immunologi (creator_code:org_t)

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By the author/editor: Fuchs, A.; Gliwinski, M.; Grageda, N.; Spiering, R.; Abbas, A. K.; Appel, S.; show more...; Bacchetta, R.; Battaglia, M.; Berglund, David, ...; Blazar, B.; Bluestone, J. A.; Bornhauser, M.; ten Brinke, A.; Brusko, T. M.; Cools, N.; Cuturi, M. C.; Geissler, E.; Giannoukakis, N.; Golab, K.; Hafler, D. A.; van Ham, S. M.; Hester, J.; Hippen, K.; Di Ianni, M.; Ilic, N.; Isaacs, J.; Issa, F.; Iwaszkiewicz-Grz ...; Jaeckel, E.; Joosten, I.; Klatzmann, D.; Koenen, H.; van Kooten, C.; Korsgren, Olle; Kretschmer, K.; Levings, M.; Marek-Trzonkowsk ...; Martinez-Llordel ...; Miljkovic, D.; Mills, K. H. G.; Miranda, J. P.; Piccirillo, C. A ...; Putnam, A. L.; Ritter, T.; Roncarolo, M. G.; Sakaguchi, S.; Sanchez-Ramon, S ...; Sawitzki, B.; Sofronic-Milosav ...; Sykes, M.; Tang, Q. Z.; Vives-Pi, M.; Waldmann, H.; Witkowski, P.; Wood, K. J.; Gregori, S.; Hilkens, C. M. U ...; Lombardi, G.; Lord, P.; Martinez-Caceres ...; Trzonkowski, P.; show less...

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AGRICULTURAL SCIENCES: AGRICULTURAL SCI ...; and Veterinary Scien ...; and Pathobiology

Articles in the publication: Frontiers in Imm ...

By the university: University of Gothenburg; Uppsala University

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