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Long-term predictio...
Long-term prediction of prostate cancer diagnosis and death using PSA and obesity related anthropometrics at early middle age: Data from the malmö preventive project
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- Malm, Johan (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Masspektrometri,Sektion V,Institutionen för kliniska vetenskaper, Lund,Clinical Protein Science and Imaging,Department of Translational Medicine,Faculty of Medicine,Clinical Chemistry, Malmö,Lund University Research Groups,Mass Spectrometry,Section V,Department of Clinical Sciences, Lund
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- Gerdtsson, Axel (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Surgery,Lund University Research Groups,Department of Translational Medicine,Faculty of Medicine
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- Thorek, D. L. J. (författare)
- Johns Hopkins University School of Medicine
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- Carlsson, Sigrid, 1982 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Memorial Sloan-Kettering Cancer Center
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Malm, J. (författare)
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- Scardino, P. T. (författare)
- Memorial Sloan-Kettering Cancer Center
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- Vickers, A. (författare)
- Memorial Sloan-Kettering Cancer Center
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- Lilja, Hans (författare)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Memorial Sloan-Kettering Cancer Center,University of Oxford
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- Ulmert, David (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Memorial Sloan-Kettering Cancer Center
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(creator_code:org_t)
- 2017-12-05
- 2018
- Engelska.
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 9:5, s. 5778-5785
- Relaterad länk:
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http://www.oncotarge...
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Objectives: To evaluate whether anthropometric parameters add to PSA measurements in middle-aged men for risk assessment of prostate cancer (PCa) diagnosis and death. Results: After adjusting for PSA, both BMI and weight were significantly associated with an increased risk of PCa death with the odds of a death corresponding to a 10 kg/m2 or 10 kg increase being 1.58 (95% CI 1.10, 2.28; p = 0.013) and 1.14 (95% CI 1.02, 1.26; p = 0.016) times greater, respectively. AUCs did not meaningfully increase with the addition of weight or BMI to prediction models including PSA. Materials and Methods: In 1974 to 1986, 22,444 Swedish men aged 44 to 50 enrolled in Malmö Preventive Project, Sweden, and provided blood samples and anthropometric data. Rates of PSA screening in the cohort were very low. Documentation of PCa diagnosis and disease-specific death up to 2014 was retrieved through national registries. Among men with anthropometric measurements available at baseline, a total of 1692 men diagnosed with PCa were matched to 4190 controls, and 464 men who died of disease were matched to 1390 controls. Multivariable conditional logistic regression was used to determine whether diagnosis or death from PCa were associated with weight and body mass index (BMI) at adulthood after adjusting for PSA. Conclusions: Men with higher BMI and weight at early middle age have an increased risk of PCa diagnosis and death after adjusting for PSA. However, in a multivariable numerical statistical model, BMI and weight do not importantly improve the predictive accuracy of PSA. Risk-stratification of screening should be based on PSA without reference to anthropometrics. © Assel et al.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- BMI
- Obesity
- Prostate cancer
- PSA
- Weight
- prostate specific antigen
- adult
- adulthood
- anthropometry
- Article
- blood sampling
- body mass
- body weight gain
- cancer mortality
- cancer registry
- cancer risk
- cancer screening
- cohort analysis
- controlled study
- disease association
- follow up
- human
- major clinical study
- male
- middle aged
- outcome assessment
- prediction
- risk assessment
- Sweden
- Swedish citizen
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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