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Dietary intake of f...
Dietary intake of flavonoids and ventilatory function in european adults: A GA2LEN study
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- Garcia-Larsen, V. (författare)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Program Human Nutr, Baltimore, MD 21205 USA.
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- Thawer, N. (författare)
- Imperial Coll London, Natl Heart & Lung Inst, Resp Epidemiol & Publ Hlth Grp, London SW7 1BU, England.
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- Charles, D. (författare)
- Imperial Coll London, Natl Heart & Lung Inst, Resp Epidemiol & Publ Hlth Grp, London SW7 1BU, England.;Queen Mary Univ London, Barts & London Sch Med, London E1 1BZ, England.
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- Cassidy, A. (författare)
- Univ East Anglia, Norwich Med Sch, Dept Nutr, Norwich NR4 7TJ, Norfolk, England.
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- Van Zele, T. (författare)
- Univ Ghent, Upper Airway Res Lab, B-9000 Ghent, Belgium.,Univ Southern Denmark, Dept Publ Hlth, Res Unit Gen Practice, DK-5000 Odense C, Denmark.
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Thilsing, T. (författare)
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- Ahlström, M. (författare)
- Helsinki Univ Hosp, Skin & Allergy Hosp, Hus Helsinki 00029, Finland.
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- Haahtela, T. (författare)
- Helsinki Univ Hosp, Skin & Allergy Hosp, Hus Helsinki 00029, Finland.
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- Keil, T. (författare)
- Charite, Dept Pediat, D-10117 Berlin, Germany.;Charite, Inst Social Med Epidemiol & Hlth Econ, D-10117 Berlin, Germany.
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- Matricardi, P. M. (författare)
- Wurzburg Univ, Inst Clin Epidemiol & Biometry, D-97070 Wurzburg, Germany.
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- Brożek, G. (författare)
- Med Univ Silesia, Coll Med, Dept Epidemiol, PL-40752 Katowice, Poland.
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- Kowalski, M. L. (författare)
- Med Univ Lodz, Dept Immunol Rheumatol & Allergy, PL-90647 Lodz, Poland.
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- Makowska, J. (författare)
- Med Univ Lodz, Dept Immunol Rheumatol & Allergy, PL-90647 Lodz, Poland.
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- Niżankowska-Mogilnicka, E. (författare)
- Jagiellonian Univ, Sch Med, PL-31008 Krakow, Poland.
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- Rymarczyk, B. (författare)
- Med Univ Silesia, Clin Dept Internal Dis Allergol & Clin Immunol, PL-40055 Katowice, Poland.
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- Loureiro, C. (författare)
- Coimbra Univ Hosp, Dept Immunoallergol, P-3000075 Coimbra, Portugal.
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- Bom, A. T. (författare)
- Coimbra Univ Hosp, Dept Immunoallergol, P-3000075 Coimbra, Portugal.
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- Bachert, C. (författare)
- Karolinska Inst, Div ENT Dis, S-17177 Stockholm, Sweden.
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- Forsberg, Bertil (författare)
- Umeå universitet,Yrkes- och miljömedicin,Umea Univ, Dept Publ Hlth & Clin Med, Div Occupat & Environm Med, S-90187 Umea, Sweden.
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Torén, Kjell, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine,Univ Gothenburg, Sect Occupat & Environm Med, S-40530 Gothenburg, Sweden.
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- Potts, J. F. (författare)
- Imperial Coll London, Natl Heart & Lung Inst, Resp Epidemiol & Publ Hlth Grp, London SW7 1BU, England.
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- Burney, P. G. (författare)
- Imperial Coll London, Natl Heart & Lung Inst, Resp Epidemiol & Publ Hlth Grp, London SW7 1BU, England.
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Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Program Human Nutr, Baltimore, MD 21205 USA Imperial Coll London, Natl Heart & Lung Inst, Resp Epidemiol & Publ Hlth Grp, London SW7 1BU, England. (creator_code:org_t)
- 2018-01-15
- 2018
- Engelska.
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Ingår i: Nutrients. - Basel : MDPI AG. - 2072-6643. ; 10:1
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Abstract
Ämnesord
Stäng
- Background: Flavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce. Methods: A stratified random sample was drawn from the GA2LEN screening survey, in which 55,000 adults aged 15 to 75 answered a questionnaire on respiratory symptoms. Post-bronchodilator spirometry was obtained from 2850 subjects. Forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV1) and FVC (FEV1/FVC), FVC below lower limit of normal (FVC < LLN), and FEV1/FVC < LLN were calculated. Intake of the six main subclasses of flavonoids was estimated using the GA2LEN Food Frequency Questionnaire. Adjusted associations between outcomes and each subclass of flavonoids were examined with multivariate regressions. Simes’ procedure was used to test for multiple comparisons. Results: A total of 2599 subjects had valid lung function and dietary data. A lower prevalence of FVC < LLN (airway restriction) was observed in those with higher total flavonoid (adjusted odds ratio (aOR), higher vs. lowest quintile intake 0.58, 95% Confidence Interval (CI) 0.36, 0.94), and pro-anthocyanidin intakes (aOR 0.47, 95% CI 0.27, 0.81). A higher FEV1/FVC was associated with higher intakes of total flavonoids and pro-anthocyanidins (adjusted correlation coefficient (a β-coeff 0.33, 0.10, 0.57 and a β-coeff 0.44, 95% CI 0.19, 0.69, respectively). After Simes’ procedure, the statistical significance of each of these associations was attenuated but remained below 0.05, with the exception of total flavonoids and airway restriction. Conclusions: This population-based study in European adults provides cross-sectional evidence of a positive association of total flavonoid intake and pro-anthocyanidins and ventilatory function, and a negative association with spirometric restriction in European adults. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Flavonoids
- GA2LEN
- Lung function
- Pro-anthocyanidins
- flavonoids
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Garcia-Larsen, V ...
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Thawer, N.
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Charles, D.
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Cassidy, A.
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Van Zele, T.
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Thilsing, T.
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visa fler...
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Ahlström, M.
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Haahtela, T.
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Keil, T.
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Matricardi, P. M ...
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Brożek, G.
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Kowalski, M. L.
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Makowska, J.
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Niżankowska-Mogi ...
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Rymarczyk, B.
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Loureiro, C.
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Bom, A. T.
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Bachert, C.
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Forsberg, Bertil
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Janson, Christer
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Torén, Kjell, 19 ...
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Potts, J. F.
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Burney, P. G.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Näringslära
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Nutrients
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Karolinska Institutet
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Uppsala universitet